Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020538 (hypertension)
 170,190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The importance and contribution of optimal blood pressure control to improvement in quality of life, cognitive abilities inclusive, have been established and accepted by all and sundry. In the elderly population, however, hypertension and cognitive dysfunction are commonly encountered disorders. The objective is to determine the role of blood pressure on the cognitive performances of Nigerian elderly hypertensive patients. A total of 327 randomly selected elderly subjects above 60 years of age comprising 153 hypertensive: 53 males (34.64%) and 100 females (65.36%) with a mean age of 66.65 +/- 6.64 years; and 174 normotensive healthy controls: 63 males (36.21%) and 111 females (63.79%) with a mean age of 67.29 +/- 6.45 years were studied. The mean blood pressure for the hypertensive was 160/110mmHg (range 150/94 - 190/130mmHg) while it was 120/74mmHg (range 110/50 - 139/89mmHg) for the normotensives. The cognitive testing was done with the Community Screening Instrument for Dementia (CSI'D'). The main outcome measures were cognitive test scores (CSI'D' scores) and blood pressure readings. The CSI'D' scores correlated significantly with higher educational level (P < 0.05; P = 0.0372) but the mean CSI'D' scores of hypertensives was not significantly different from that of normotensives (P>0.05). The diastolic blood pressure was the strongest predictor of the presence of cognitive impairment with a statistically significant linear relationship (P = 0.013). This study assessed the effect of blood pressure on cognitive performance. The evidence from the study showed that blood pressure has no effect on cognitive performance of subjects generally but among hypertensive subjects, diastolic blood pressure negatively correlates with cognitive performance.
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PMID:Cognitive performance of hypertensive elderly Nigerians: a case control study. 1674 60

Medulloblastoma is one of the most common malignant childhood brain tumors. It is a primitive neuroectodermal tumor (PNET) and predominantly arises in the cerebellum and 4th ventricle. Most cases of medulloblastoma are sporadic, but some predisposition syndromes are known, such as SUFU and Gorlin syndromes. Most often intracranial hypertension reveals the disease typically with headache and vomiting. However, the frequent atypical presentation should not delay neuroradiological investigations. Brain and spinal MRI can establish the diagnosis of posterior fossa tumor and define the extent of the disease. CSF study completes the staging. Histologic examination of the tumor confirms the diagnosis of medulloblastoma. Patients are classified into 2 risk groups: standard-risk medulloblastoma, defined by nonmetastatic disease treated by total or subtotal tumor resection; and high-risk patients who have disseminated disease and/or residual disease. Tumor molecular genetic findings allow the use of emerging prognostic factors and may ultimately contribute to the development of targeted therapy. Current treatment in the oldest children combines surgical resection followed by radiotherapy and chemotherapy. The aim of recent studies was to increase survival and decrease sequelae by reducing CSI in older children with standard risk medulloblastoma. Treatment in younger patients is as much as possible restricted to surgery and chemotherapy. However, long-term sequelae after treatment for medulloblastoma remain frequent and the detection and treatment of those sequelae is an essential part of the follow-up of the patients.
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PMID:[Childhood medulloblastoma]. 1899 98