Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0020538 (
hypertension
)
170,190
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
This article narrates the development and promotion in the 1950s and 1960s of Merck, Sharp & Dohme's
Diuril
(chlorothiazide), an antihypertensive drug, which played a significant role in the redefinition of
high blood pressure
as a widespread target for chronic pharmaceutical consumption. The joined careers of
Diuril
and
hypertension
in the late twentieth century demonstrate the connections between the clinical research, clinical practice, and marketing practices through which pharmaceuticals and disease categories come to define one another. By examining a series of internal documents preserved in the Merck Archives alongside a careful reading of the clinical literature and industry journals of the time, this article explores how the ambitions of marketers, physicians, and public health advocates found convergence in the expanding pharmaceutical prevention of chronic diseases.
...
PMID:Releasing the flood waters: diuril and the reshaping of hypertension. 1632 86
