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Query: UMLS:C0020538 (hypertension)
 170,190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The relevance of maternal macronutrient deficiency on developmental origin of health and adult disorders has been well studied but not that of micronutrients. We hypothesized that chronic maternal dietary mineral (copper or zinc) or vitamin E restriction modulates the expression of placental 11 beta hydroxysteroid dehydrogenase-2 (11 beta HSD-2) per se predisposing the offspring to insulin resistance (IR) and hypertension in later life. Female weaning Swiss albino mice received a control or a 50% of Vitamin-E or Zn or Cu restricted diet and mated with control males. Pups born to the dams on the restricted diet had significantly (P < 0.001) reduced body weight and crown rump length. These offsprings were weaned on to the restricted diet till postnatal day 180. Glucose intolerance in association with hyperinsulinemeia (IR), hyperlipidemeia and increased systolic blood pressure were recorded in all the offsprings of micronutrient restricted groups. Placental 11 beta HSD-2 expression was attenuated, while activities of glucocorticoid -insensitive enzymes were unchanged in all the restricted groups. Thus, the present study reiterates the importance of micronutrients during pregnancy because chronic maternal micronutrient deficiency may alter placental 11 beta HSD-2 expression and predispose the offspring to IR and hypertension in later life.
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PMID:Does the maternal micronutrient deficiency (copper or zinc or vitamin E) modulate the expression of placental 11 beta hydroxysteroid dehydrogenase-2 per se predispose offspring to insulin resistance and hypertension in later life? 1958 52

The present study was designed to evaluate the lipid peroxidation and non-enzymatic antioxidants in pregnancyinduced hypertension (PIH) compared with healthy normal pregnant and non-pregnant as controls. 75 cases were studied of which 25 were normal healthy controls (Group A), 25 healthy pregnant women (Group B) of third trimester and 25 were PIH (Group C) of the same trimester. In PIH, malondialdehyde a lipid peroxidation product was significantly increased as compared to normal pregnant and non-pregnant controls. The nonenzymatic antioxidants like reduced glutathione, Vitamin-E, Vitamin-C and Vitamin-A were significantly decreased in normal pregnants as compared to controls. A further significant decrease was noticed in PIH compared to normal pregnants. A significant negative correlation was detected between lipid peroxidation and non-enzymatic antioxidant levels. Our study clearly indicates a relationship between elevated lipid peroxidation, decreased non-enzymatic antioxidant in PIH. The measurement of non-enzymatic antioxidants in plasma may be useful predictor of the likely development of PIH.
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PMID:Correlation between lipid peroxidation and non-enzymatic antioxidants in pregnancy induced hypertension. 2310 19