Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0020538 (hypertension)
 170,190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Three cases, involving lethal circulatory collapse in patients who received bromocriptine mesylate (Parlodel) for the suppression of lactation, are reported. These accidents expand the scope of severe side-effects that appear to be attributable to a widely used pharmacological approach to ablactation during puerperium. The circumstances that surrounded the maternal deaths in these instances are consistent with previous clinical observations and epidemiological research, suggesting that pregnancy induced hypertension increases the risks for severe untoward effects from bromocriptine. The common denominator in these side-effects appears to be vasospasm; a paradoxical reaction to a drug, the primary pharmacological effect of which is vasodilation. The reported cases came to the attention of the author through medicolegal inquiries. This underlines the potential value of malpractice reviews, as a research tool, for the critical analysis of rare adverse occurrences and unsuspected complications in the clinical practice of medicine.
 ...
PMID:Lethal cardiovascular complications in patients receiving bromocriptine for ablactation. 766 53

Erectile dysfunction is more common than previously thought in men older than 40 years, perhaps because contributing medical risk factors increase with age. The medical history is of prime importance in outlining these factors, the most common of which are diabetes, hypertension, and smoking. Nocturnal penile tumescence and rigidity testing with a portable home monitor may be helpful in determining whether the cause of erectile dysfunction is primarily organic or psychological. Specific therapeutic measures include sex therapy, psychotherapy, treatment for alcohol or tobacco dependency, replacement of offending medications, improved glycemic control, constriction rings, vascular surgery, androgen replacement therapy, bromocriptine mesylate (Parlodel), and thyroid, adrenal, or pituitary replacement therapy. Nonspecific therapies include yohimbine hydrochloride (Yocon), use of vacuum tumescence devices, intracorporeal injections, and penile implants.
 ...
PMID:Erectile dysfunction. Are you prepared to discuss it? 771 86

We performed a left ventricular aneurysmectomy for a left ventricular aneurysm associated with acromegaly in a 62-year-old man. Bromocriptine mesilate was administered to suppress high growth hormone (GH) levels, and there were no complications during or after the operation. The majority of patients with acromegaly die of cardiovascular diseases such as cardiomegaly, hypertension, arteriosclerosis of the coronary arteries, congestive heart failure, valvular disease, and arrhythmia. Ventricular aneurysm is a rare complication of acromegaly. In order to safely operate, it is important to control serum GH levels and pay special attention to the well-known complications of acromegaly such as diabetes mellitus and hypertension.
 ...
PMID:[A case of left ventricular aneurysm associated with acromegaly]. 833 39

The spate of medicolegal inquiries following the disqualification of Parlodel (bromocriptine mesylate) by the Food and Drug Administration for postpartum ablactation, uncovered previously unreported side effects associated with its postpartum administration. In 1994, bromocriptine mesylate was withdrawn from the market as a milk suppressant. Since this time, over a dozen cases of postpartum intracranial hemorrhages associated with its use have been reported. We describe three additional cases of postpartum intracranial hemorrhage related to bromocriptine usage. One patient, previously normotensive, developed hypertension and a headache; initial CT was normal, but CT 24 h later demonstrated intracranial hemorrhage. This suggests that the blood-pressure elevation was drug-induced and was the cause, rather than the consequence, of bromocriptine-related intracranial hemorrhage.
 ...
PMID:The role of hypertension in bromocriptine-related puerperal intracranial hemorrhage. 1133 13