Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020538 (hypertension)
 170,190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Terazosin (Hytrin; Abbott Laboratories, North Chicago, IL) is a new, selective alpha 1-adrenoceptor blocking agent used on once-a-day basis for therapy of mild-to-moderate hypertension. Its pharmacologic properties are similar to those of prazosin. Terazosin however, differs from prazosin in that its water solubility is 25 times greater than that of prazosin and its elimination half-life is about three times that of prazosin. Greater water solubility facilitates intravenous formulation, and longer half-life allows once-daily administration of terazosin. Terazosin is effective in lowering blood pressure and has a beneficial effect on plasma lipid profile. The major advantage of terazosin compared with prazosin, however, is its long duration of action. Terazosin is safe and effective when used in combination with diuretics and other antihypertensive agents, and in the long-term treatment of patients with mild to moderate essential hypertension.
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PMID:Terazosin: a new alpha adrenoceptor blocking drug. 135 83

BPH is a diagnosis that needs to be considered and evaluated in older male renal disease/failure patients. Rather than proceeding to the invasive treatment options, Hytrin should be considered as the treatment of choice. Not only can it relieve the symptoms of BPH, but also be an effective treatment for hypertension. Ongoing assessment, observation for side effects, monitoring for lower urinary tract dysfunction, along with patient education and documentation are the responsibilities of nephrology nurses.
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PMID:Hytrin treatment of hypertension and benign prostatic hyperplasia. 754 Mar 85

alpha-adrenoceptor antagonists have traditionally been used in the treatment of hypertension but in recent years they have become increasingly common in the treatment of benign prostatic enlargement (BPE), where they reduce the 'dynamic' component of bladder outlet obstruction and appear to have additional actions to reduce irritative symptoms of the disease. Prazosin (Hypovase), Alza), doxazosin (Cardura), Pfizer), indoramin (Doralese), Wyeth-Ayerst Pharmaceuticals Inc.) and terazosin (Hytrin), Abbott Laboratories) are currently available in the UK for BPE but these agents have cardiovascular actions in a significant number of patients, inducing effects which must be considered adverse unless the patient also requires treatment for mild-to-moderate hypertension. The uroselective alpha-adrenoceptor antagonists tamsulosin (Flomax), Yamanouchi Pharmaceutical Co. Ltd.) and alfuzosin (Xatral), Sanofi-Synthelabo) have recently been introduced. These agents exert their selectivity via different mechanisms; selective tissue distribution for alfuzosin and alpha-adrenoceptor subtype selectivity for tamsulosin. The incidence of cardiovascular side effects for both drugs is similar to placebo. Several lines of evidence suggest that the alpha-adrenoceptor antagonists may relieve lower urinary tract (LUT) symptoms by other mechanisms additional to those which account for the reduction in bladder outlet obstruction. If correct, these agents may be of use in the treatment of other bladder conditions.
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PMID:The use of alpha-adrenoceptor antagonists in lower urinary tract disease. 1182 30