Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020538 (hypertension)
 170,190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Amylin (or islet amyloid polypeptide) has been reported to have binding sites in the central nervous system and the kidney and has been shown to activate plasma renin. It has been postulated that this peptide may be an important mechanistic link between hypertension and diabetes in the insulin resistance syndrome. To explore this issue, the effects of rat amylin on mean arterial blood pressure were investigated in anaesthetised rats. Amylin elicited a pressor response of approximately 10 mmHg (maximal at 100 pmol.kg-1) which was apparent within 30-60 s and persisted over 15 min. At higher concentrations amylin elicited a hypotensive response (negative log IC50 8.52 mol.kg-1). The novel amylin receptor antagonist AC413 (12 nmol.kg-1.min-1) reduced the pressor response but not the hypotensive effects of amylin. The peptide antagonist calcitonin gene-related peptide (CGRP)8-37 (12 nmol.kg-1.min-1) reduced the pressor response elicited by amylin and also antagonized the hypotensive effect of amylin. Pre-treatment of animals with the ganglion blocker mecamylamine (3 mg.kg-1 s.c.) reduced the pressor effect of amylin. Following the administration of the angiotensin converting enzyme inhibitor ramiprilat (300 nmol.kg-1 i.v.) the pressor response to amylin was reduced. Salmon calcitonin also elevated blood pressure in the anaesthetised rat; doses of amylin and salmon calcitonin associated with a pressor effect were associated with increases in plasma renin activity. We conclude that amylin may act centrally to elevate blood pressure in the anaesthetised rat, possibly through activation of the renin angiotensin system.
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PMID:Rat amylin mediates a pressor response in the anaesthetised rat: implications for the association between hypertension and diabetes mellitus. 908 62

To understand the actual clinical situation of osteoporosis patients in our country, 9 731 hospitalized patients with osteoporosis from HIS system of 20 national 3A-grade hospitals were selected as the research objects to analyze their general information, western medicine combined diseases, diagnostic information, relationship with the onset of 24 solar terms, and the therapeutics application. Results showed that the median age of hospitalized patients with osteoporosis disease was 72 years old, more common in women aged 60 to 74; mainly in manual workers (73.87%); most in general outpatient clinic during the admission; conditions of the most patients (81.61%) were general during hospital admission; patients were more likely hospitalized from orthopaedics department (21.94%); hospital length of stay was mainly of 8-14 days (39.96%); 34.34% of the patients had a total hospitalization cost of 5 000 yuan to 10 000 yuan; 75.01% of the patients were beneficial from national health medical insurance. The complications mainly included hypertension, diabetes, and osteoarthritis, and the complication rate was as high as 34.67% for hypertension; the most common traditional Chinese medicine syndrome was deficiency of liver-Yin and kidney-Yin (36.62%); the patients were admitted to the hospital most during 3 solar terms: beginning of summer, summer solstice and cold dew. Calcitonin salmon and calcium carbonate were most widely used in western medicine and Zhengqing Fengtongning was most widely used in traditional Chinese medicine. In conclusion, osteoporosis is more common in elderly patients, and is closely related to solar terms; integrated treatment strategies of traditional Chinese medicine and western medicine can be widely used in clinical application and have certain advantages.
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PMID:[Clinical characteristics and medicinal analysis for osteoporosis based on real world]. 2889 47