Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020538 (hypertension)
 170,190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

9 alpha-Fluorocortisol (9 alpha FF) is an analogue of cortisol with 'mineralocorticoid', 'glucocorticoid' and 'hypertensinogenic' activity. 9 alpha FF was infused at 2 mg/day for 5 days to sheep receiving a normal Na intake (100 mmol/d) and a high K intake (congruent to 800 mmol/d). K loading modified the Na retaining effects of 9 alpha FF but had no effect on the development of the hypertension. These experiments suggest that the effects of K loading on the development of 9 alpha-FF hypertension are not related simply to the effects that K has on modifying the Na retaining effects of the steroid.
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PMID:The influence of potassium loading on the pressor and metabolic effects of 9-alpha-fluoro-cortisol in sheep. 650 88