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Query: UMLS:C0020538 (hypertension)
 170,190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

1. The antihypertensive effect of a new beta-adrenoceptor blocking agent, trimepranol (10--14 mg/twice daily), chlorthalidone (50 mg every second day) and their combination was studied in eighteen patients with mild to moderate essential hypertension. In a controlled randomized cross-over study the drugs were given for 6 week periods. 2. A significant and equal decrease in blood pressure was achieved both with trimepranol and chlorthalidone, whereas their combination was significantly more effective. 3. Trimepranol significantly antagonized the chlorthalidone-induced hypokalemia. 4. The results favor the use of diuretic or diuretic-beta-adrenoceptor blocker combination over beta-adrenoceptor blocker monotherapy in the treatment of mild to moderate hypertension.
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PMID:Effect of diuretic, beta-adrenoceptor blocking agent and their combination on elevated blood pressure and serum potassium: a cross-over study. 2 53

The objective of the investigation was to test the impact of hypertension on the formation of free oxygen radicals which participate in the development of atherosclerosis. Using the method of luminol-dependent chemiluminescence, the authors assessed the spontaneous and stimulated production of free oxygen radicals in phagocytic cells of complete blood in a group of healthy subjects, in not treated essential hypertension (EH), essential hypertension treated with metipranolol (Trimepranol Spofa) and EH treated with diltiazem (Blokalcin Lachema). A statistically significant increase of spontaneous and activated production of free oxygen radicals was found in the group of EH treated with diltiazem. Differences between the group of healthy subjects, untreated EH and hypertension treated with metipranolol were not statistically significant.
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PMID:[Free oxygen radicals in patients with hypertension]. 168 16

Forty men with hypertension, diastolic BP lower than 14.66 kPa, were treated for six months with Trimepranol, 10 mg three times per day, with echocardiographic checking of changes of the cardiac minute output and the peripheral vascular resistance at rest and during an isometric load. In patients with a low baseline vascular resistance (group A, n = 20) a substantially better therapeutic effect was recorded than in patients with a markedly elevated peripheral resistance (group B, n = 11). Trimepranol is indicated in patients with a higher heart rate at rest and with a significant increase of the latter during isometric loading tests.
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PMID:[Echocardiographic control of treatment of mild hypertension with trimepranol]. 197 53

In their review the authors submit pathophysiological comments on arterial hypertension in conjunction with general anaesthesia and they evaluate the risk of anaesthesia in hypertensive subjects. They discuss in more detail the preoperative preparation of the above patients by presenting actual data on the interactions of general anaesthetics with diuretics, beta-blockers, blockers of calcium channels and other antihypertensive preparations. Their own experience pertains to the preoperative administration of selected diuretics, used in this country, i.e. Trimepranol and Corinfar.
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PMID:[Preoperative preparation of patients with arterial hypertension from the viewpoint of the internist]. 233 18

On the example of a 63-year-old neurotic patient dependent on alcohol and anxiolytic drugs the author draws attention to the risk of the development of a tardive dyskinesia after the long-term administration of "neurotic doses" of neuroleptics to non-psychotic patients. The author emphasizes the greater danger in the group of patients dependent on alcohol. He describes an attempt of concurrent treatment of neurosis, tardive dyskinesia and hypertension by a non-selective beta-blocker metopranolol (Trimepranol Spofa) administered for eight months. This drug was according to the author's information administered for the first time in tardive dyskinesia. It seems that it improves tardive dyskinesia in much smaller doses than anxiety and sleep disorders.
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PMID:[Tardive dyskinesia after low doses of neuroleptics and attempts at treatment]. 256 13