Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0020538 (hypertension)
 170,190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Prostaglandins (PG) A1, B1, E2, F2 alpha and plasma renin activity (PRA) were measured by radioimmunoassay in 8 patients with unilateral artery stenosis, 7 hypertensive patients with unilateral renal atrophy without stenosis ans 20 controls. The measurement of the PG and PRA in the hypertensive group was performed in the infra-renal inferior vena cava and in the two renal veins. PRA and PGA1 were significantly raised in the renovascular hypertensive patients but no significant change was observed in the group with unilateral renal atrophy. On the other hand, the PGE2 and PGF2 alpha were raised in both groups, especially in the renal veins on the stenosed or atrophic side. There was a positive significant correlation between PRA and PGA1 and PGB, but none with PGE2 or PGF2 alpha. This study suggests that the increase in PGA1 and PGE2 represents a secondary hypertensive mechanism which is diuretic and natiuretic. The increase of PGF2 alpha represents a direct mechanism of hypertension. Simultaneous measurement of the vasopressor (PRA and PGF2 alpha) and vasodepressor (PGA and PGE) systems may give a better diagnostic and prognostic approach to renovascular hypertension.
Arch Mal Coeur Vaiss 1979 Nov
PMID:[Prostaglandins in renovascular arterial hypertension]. 11 9

38 cases of severe hypertension due to a vascular abnormality of the renal pedicle were studied in children under 16 years of age, 18 boys and 20 girls. The most common presentation was at routine clinical examination. The diagnosis of an abnormality of the renal artery was suggested by the appearances of intravenous urography. There were many causes; 4 aneurysms of the renal artery or its branches, 4 fibromuscular dysplasias with one case of bilateral fibromuscular dysplasia, 4 idiopathic stenoses, 2 endarteritis, and 6 thromboses revascularised to variable degrees (2 after umbilical vein catheterisation and one due to DLE). In three cases the hypertension was related to compression of the pedicle by a tumour of haematome, and 14 cases had multiple arterial lesion. In the latter group, 6 cases of neurofibromatosis, 2 cases of William and Beuren's disease, 1 case of generalised Elastorhexia, 2 cases of aortic medio stenosis, probably Takayashu's disease, and 3 unidentified conditions. Surgery was performed on 29 patients, 21 of whom had unilateral lesions and were definitively cured of hypertension. Of the 8 cases with multiple lesions, only 2 were completely corrected with cure of their hypertension.
Arch Mal Coeur Vaiss 1979 Nov
PMID:[Arterial hypertension caused by anomaly of the renal artery or its branches in children]. 11 10

The variability of blood pressure measurements is studied, in a standardized screening, by comparing the measures obtained during a medical examen and those made by technicians under different circumstances. This variability is important. A systematic bias is due to the digit preference for the zero value by the doctors. Besides, strong subject/obser interaction accounts partly for higher values measured in the medical exam. The mean blood pressures and the prevalence of hypertension are increased under some circumstances close to those of everyday life and labile hypertension is very frequent. The individual variability of the measure and the prevalence of hypertension are reduced by a standardized technique when applied under favorable circumstances by technicians. The reproductibility of this measure is good but the simultaneous taking into account of two successive measures still reduces much this prevalence. In these conditions it is very difficult to estimate the prevalence of hypertension in the population: an example is given where this frequency varies in the proportion of 1 to 6 according to the measures considered. The implications of this variability on the screening of hypertension are discussed.
Arch Mal Coeur Vaiss 1979 Oct
PMID:[Variations in blood pressure measurement during systematic screening tests and their effects on public health]. 12 Jul 20

This study is based on a series of 1919 hypertensive patients examined consecutively either in hospital or in the out patient clinic between 1969 and 1977 and reviewed in February 1977 by a postal questionnaire. The initial presentation of in-patients and out-patients differed very significantly in the same specialised department: the patients hospitalised were seen at a more advanced stage of their hypertensive illness. Neither group was truly representative of the general population of hypertensive patients. The percentage of patient compliance was only slightly lower in the out-patients. The mortality rate observed did not differ significantly from the expected mortality rate in out-patients; despite treatment it remained over 200% greater in the hospitalised group. It would seem desirable to develop out-patient rather than in-patient hospital facilities for the treatment of hypertension, despite the foreseeable practical difficulties.
Arch Mal Coeur Vaiss 1979 Oct
PMID:[Comparison of hospitalized hypertensive patients and those consulting in a specialized unit. Initial clinical state and patient compliance]. 12 Jul 21

Medical insurance gives a very incomplete view of the spectrum of hypertensive disease, based only on the results of clinical examination of persons undergoing check-ups in the Medical Examination Centres: 39 850 in 1976, or on those examined by consulting physicians according to article L293: 23 308 in 1976, or being examined for invalidity allowance: 11 471 in 1976. The complications of hypertension do not appear in these statistics under the label of hypertension. They have been estimated and, when taken into account, increase the total number of hypertensive patients detected in 1976 by the Medical Insurance to 99 318, that is to say 0,25% of the covered population. An inquiry carried out on 130 male hypertensives in the Paris region tends to approach the medico-economic profile of the hypertensive patient with respect to age.
Arch Mal Coeur Vaiss 1979 Oct
PMID:[Health insurance and hypertension. Review of current data]. 12 Jul 22

15 patients with Stage II (VHO Classification) hypertension were studied before treatment. The following systolic time intervals were measured: 1) total electromechanical systolic period (QS2); 2) left ventricular ejection time (LVET); 3) interval between the first and second sounds (S1 S2); 4) pre-ejection period (PEP); 5) interval between the start of QRS and the first sound (QS1); 6) isovolumetric contraction time (ICT); 7) PEP/LVET ratio. The values measured were compared to the theoretical values obtained by the Weissler regression methods, taking into consideration the sex of the patient and the heart rate. QS1 and the ICT were both a slightly longer than normal; the PEP was increased by 25.6% (26.8 ms), whilst the LVET was decreased by 7.9% (24.0 ms), both differences being significant; QS2 increased by 1.1% (to 4.9 ms) but this was not significant; the PEP/LVET ratio was 0.479 +/- 0.12. These results seem to characterise moderate systemic hypertension with a significant relation between the variations of PEP, LVET and PEP/LVET with the diastolic blood pressure; although they have no absolute value, these results may be used in a longitudinal study to follow the course of hypertension and to study the effects of treatment.
Arch Mal Coeur Vaiss 1979 Nov
PMID:[Systolic time intervals in essential hypertension. I. Study of untreated patients]. 12 28

Characteristic changes in the systolic time intervals in Stage II (WHO Classification) hypertension have been demonstrated comprising an increase in the pre ejection period (PEP), a decrease in the left ventricular ejection time (LVET) both statistically significant, and an increase in the PEP/LVET ratio. We have studied the variations brought about by effective hypotensive therapy with an alpha and beta blocking agent (Labetalol) in 15 patients over a period of 90 days, with an average dosage of 420 mg/day in three divided doses. There was no significant variations in the PEP, but the LVET which had been reduced by 7.9% returned to within 2.8% of normal, with a reduction in the PEP/LVET ratio. The variations of these systolic indices (generally considered to be the most sensitive assessment of left ventricular function) seem to show that the hypotensive effect of labetalol is not related to a reduction in cardiac efficiency.
Arch Mal Coeur Vaiss 1979 Nov
PMID:[Systolic time intervals in essential hypertension. II. Variations produced by treatment with labetalol]. 12 29

The authors report the case of a 45 year old man who presented with a combination of a phaechromocytoma and obstructive cardiomyopathy. They discuss the possible inter-relationships between hypertension, catecholamines, phaeochromocytoma, and outflow stenosis.
Arch Mal Coeur Vaiss 1976 May
PMID:[Relationships between pheochromocytoma and obstructive myocardiopathy. Apropos of a case]. 13 46

During the course of an aorto-femoral bypass in a normotensive young man, an inferior polar artery arising low on the aorta, and supplying the right kidney, was ligated. The limited ischaemia (demonstrated by later arteriography) of the parenchyma at the pole of the kidney was responsible, during the following weeks, for severe hypertension with a raised level of circulating plasma renin, but one that was rapidly treatable. This finding, which was fortuitous but could be ranked as "experimental", demonstrates the important role of abnormal polar arteries and of the renal parenchyma in human arterial hypertension. Such may, for example, be the underlying disorder in cases of hypertension after the transplantation of a kidney with an "uncontrolled" polar artery arising from the aorta, for the so-called "pyelonephritic" hypertension in pregnant patients caused by defective blood supply in an inter-pyramidal artery and corresponding subcortical infarction of the kidney, and for curing hypertension in the adult when isolated polar arteries arising from the aorta and stenosed at their point of origin are reimplanted into the main renal artery.
Arch Mal Coeur Vaiss 1977 Nov
PMID:[Reversible "experimental" human arterial hypertension after fortuitous ligation of an isolated polar renal artery of aortic origin]. 41 79

10 cases of myocardial infarction in females (mean age, 41 years, 4 months) on estrogen/progestin compounds for oral contraception have shown up the determinant role of the associated atherogenic risk factors. All patients had 1 other risk factor. In 6 cases there was hyperlipidemia with a cholesterol of above 2.60 and hypertriglyceridemia in 1 case. A family history of coronary artery disease was present in 5 cases. There was heavy tobacco consumption in 8 of the 10 cases. All of these factors, especially in combination, increase the risk of infarction in a female on estrogen/progestin tablets and constitute a contraindication to their use. 2 of the patients had hypertension, 2 were obese, and 1 was a mild diabetic. There was no warning in 1 case in 2, and early dilatation in 4 of the 10 cases. Coronary arteriography on 5 of 7 patients so examined revealed coronary lesions involving 1 trunk. The histological appearances of the occluded segment of the left coronary trunk in the 27-year-old patient who died were those of an organized occluding thrombus, perhaps having developed over a slight thickening of the intima.
Arch Mal Coeur Vaiss 1977 Sep
PMID:[Myocardial infarct and oral contraception]. 41 87


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>