Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020538 (hypertension)
 170,190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Loin pain may be a major presenting symptom in patients with glomerulonephritis. Most of these patients show an underlying focal and segmental proliferative glomeruloneyphritis and there may be associated deposits of IgA and Igg in the mesangium. In this group of patients, vascular lesions are often prominent in the absence of hypertension. Episodes of recurrent macroscopic hematuria also occur, but the pain cannot be attributed to colic due to blood clots in the ureter.
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PMID:Loin pain as a presenting symptom in idiopathic glomerulonephritis. 12 72

A 37-year old male with a history of idiopathic nephrotic syndrome, hypertension, severe headaches and transient ischemic attacks developed ischemic colitis with stricture formation of the spelnic flexure. Eschemic changes were secondary to vascular lesions involving the middle colic artery and mulitple smaller arteries and arterioles. The vascular lesion is localized to the intimal layer with proliferation of spindle-shaped cells indentical to the gastrointestinal lesion of malignant atrophic papulosis (Degos' disease). The patient had no skin biopsy, or history of skin lesions. This case represents ischemic colitis in a patient with malignant atrophic papulosis with either absent or unrecognized skin lesions.
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PMID:Ischemic colitis and malignant atrophic papulosis. 87 Nov 16

Erythrocyte porphobilinogen synthase deficiency was confirmed by the determination of its activity in blood and also by the high levels of both porphyrins and 5-aminolaevulinic acid in the urine of two siblings. They presented with a picture of porphyric attack characterized by abdominal colic pain, high blood pressure, tachycardia and severe constipation. The profile of both porphyrins and their precursors in urine and blood resembled lead poisoning. However, this was ruled out because both patients had normal blood levels of lead. Furthermore, porphobilinogen synthase activity did not normalize when it was determined in the presence of dithiothreitol or dithiothreitol plus zinc chloride. No other causes to account for a deficiency in porphobilinogen synthase activity were identified. The simultaneous occurrence of similar clinical and biochemical symptoms suggests that the same triggering factor was present. Because the activity of porphobilinogen synthase was less than 4% of normal values, it is possible that these patients were homozygotes with respect to this defect, which could explain the presence of clinical symptoms. We propose that this metabolic defect is not uncommon and it should be kept in mind when diagnosing of porphyrias or heavy metal intoxications.
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PMID:Deficiency of porphobilinogen synthase associated with acute crisis. Diagnosis of the first two cases in Chile by laboratory methods. 189 53

Although the toxicity of lead was recognized centuries ago, concern was restricted to overt symptoms: colic, encephalopathy, anemia, or renal disease. Two major reasons for lack of progress in restricting toxicity were that interest was limited to occupational exposures and there was lack of awareness of specific biochemical or metabolic effects. Identification of subclinical effects has been possible the last 15 or 20 years because of the development of sensitive measures to detect cognitive and behavioral changes that are not apparent clinically and because of methods to measure the reduced activity of heme enzymes. This progress was driven by basic and clinical research that resulted in a better understanding of cellular toxicology. The new awareness prompted the lowering of acceptable occupational exposures, as measured by blood lead from 80 to 40 to 60 micrograms/dL range, and the establishment of maximum recommended exposures in children to a blood lead level of 25 micrograms/dL. Lowering the lead content in gasoline has been accomplished by a nearly 50% decrease in average blood levels of persons in the United States (NHANES II data). Current research implicates lead as a contributing etiologic factor in a number of common diseases affecting large portions of the population such as subtle cognitive and neurological deficits, hypertension, congenital malformations, immunotoxicity, and deficits in growth and development. For each of these disorders there may be multiple etiologic factors; the scientific challenge is to develop sensitive methodology to detect the specific role of lead. Other potential subtle health effects include the influence of small amounts of lead on cell proliferation and lead as a cofactor in carcinogenesis.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Lead toxicity: from overt to subclinical to subtle health effects. 220 87

This article discusses the indications for imaging of the urinary tract from the general practitioners' point of view. Urography should be used in the control of patients with previous attacks of ureteral colic, in patients presenting macroscopic hematuria and as a preoperative investigation prior to extracorporal shock wave lithotripsy (ESWL). Ultrasound should be chosen in patients with microscopic hematuria and non-specific abdominal pain. Computed tomography should be used in cases with non-specific findings using urography and ultrasound. There are no indications for imaging in women with recurrent urinary tract infection, in men with benign prostatic hypertrophy and in the evaluation of hypertension.
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PMID:[Imaging of the urinary tract in adults. A guideline for general practice]. 227 43

The natural history of Williams syndrome, including medical complications, growth patterns, and problems in adulthood, was investigated. A growth pattern characterized by delay in the first 4 years of life, catch-up growth in childhood, and low ultimate adult height was found. Despite multiple medical problems in infancy, including feeding problems, failure to thrive, colic, and otitis media, mean age at diagnosis was 6.4 years. Developmental disabilities and cardiovascular disease were the major concerns in childhood. The older children developed progressive joint limitation and hypertonia. Adult patients were handicapped by their developmental disabilities. Hypertension, and gastrointestinal and genitourinary problems occurred frequently. Independent living and competitive employment were limited less by the individual's physical problems than by the psychologic and adaptive limitations. Williams syndrome is a progressive disorder with multisystem involvement.
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PMID:Natural history of Williams syndrome: physical characteristics. 245 79

The authors report the case of a 10-year-old girl who died after suffering from severe erythromelalgia combined with digestive and general disorders associated with multiple vegetative disturbances (high blood pressure, hypothermia, colic and urinary disorders, raised catecholamine levels) for 2 years. Although the appearance of the tongue was normal and in spite of the absence of genetic criteria the diagnosis of Riley-Day dysautonomia was made and its association with neural crest disorders was indicated.
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PMID:[The acrodynic form of the Riley-Day syndrome]. 279 5

115 of infra renal abdominal aorta have been operated upon between 1969 and 1984. 107 male patients (93%) and 8 female (7%) were treated. Age was 65.5. Associated high blood pressure was found in 43%, smoking in 74% and coronary disease in 20.5%. Non ruptured aneurysms were 84 (73%) and diagnosis was made chiefly in ischemia of lower limbs, ruptured were 31 (27%). 4 fistulas between aorta and lower vena cava were found at surgery. Aortograms have not been done in every case, even for non ruptured aneurysms, as 19 patients have been operated without (22.6% of non ruptured aneurysms). Ultrasonography have been done in 37. Among 84 patients with non ruptured aneurysm, 6 were not operated, 2 got only palliative surgery for rest pain, and 76 (85.7%) underwent resection and grafting. 31 patients were operated when ruptured. Post operative mortality for non ruptured aneurysms was of 2 (2.63%) for resection and grafting. It was of 24 (77.4%) if ruptured. Follow-up study shows that at a five years range 62.7% of surviving operated patients are alive. Authors point out that lower limbs ischemia is still often a revealing symptom. Post operative colic ischemia is rare.
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PMID:[Aneurysms of the subrenal abdominal aorta. Apropos of 115 cases]. 409 17

The purpose of this survey was to identify complications occurring in horses with colic during anaesthesia and recovery from anaesthesia; and to determine any relationships between these complications and drugs used for induction or maintenance of anaesthesia. Two hundred and thirty nine horses were anaesthetised on a total of 250 occasions for colic surgery between January 1985 and May 1987. Of these, 189 recovered from 200 anaesthetic episodes. Most horses received xylazine and guaifenesin with either thiobarbiturate (68 per cent) or ketamine (24 per cent) and anaesthesia was maintained with either halothane (51 per cent), isoflurane (43 per cent), or first halothane then isoflurane (6 per cent). Sixty nine per cent also received an opioid. Hypotension or tachycardia were recorded in 15 and 13 per cent of anaesthesias, respectively. Arterial PO2 was less than 13.3 kPa in 17 per cent of 175 anaesthesias. None of these complications was associated with a specific anaesthetic agent. Hypertension was recorded in 11.5 per cent of anaesthesias and occurred more frequently during isoflurane anaesthesia (P < 0.05). The mean duration of anaesthesia was 126 mins (range, 50-270 mins), and was not different for horses receiving thiobarbiturate or ketamine, halothane or isoflurane. The time taken to stand after anaesthesia recorded on 149 occasions and was 63 +/- 24 mins (range, 15-135 mins). This was not different for the different anaesthetic agents. Horses that were excited or had difficulty standing up during recovery had a significantly longer duration of anaesthesia (165 +/- 51 mins) (P < 0.05) but no specific anaesthetic agent was involved. Of the 189 horses, 148 (75 per cent) survived and were discharged from the hospital. Horses that did not survive had a significantly increased prevalence of anaesthetic complications, and longer durations of anaesthesia.
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PMID:A retrospective survey of anaesthesia in horses with colic. 911 15

The authors present a case of tyrosinemia type 1, 3 years old girl at the time of diagnosis. The presenting symptoms were 3 times colic, obstipation, acute encephalopathy, hypertension, hyponatremia, according to the porphyric crisis. Her kidney function tests gave normal results during illness, only once an increased calcium turnover was observed. She has no singe of rachitis. Cirrhosis of the liver was proved by biopsy because of progressively rising gammaGT and alfa-fetoprotein levels. A new ensime-blocker (NTBC) treatment was started in an international collaboration. The authors compare the history of this case to that of others published in the literature. They summarize the pathomechanism of the disease.
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PMID:[Late onset type I tyrosinemia]. 928 Aug 76


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