Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020538 (hypertension)
 170,190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Our hunter-gatherer ancestors appeared to survive on little salt. When today's rural dwellers move to urban environments, they increase their salt intake and the salt-sensitive among them become prone to age-related increase in blood pressure and hypertension. This paper reviews our knowledge of the mechanisms of salt disposal and plasma volume regulation, salt consumption in human evolution, salt intake and prevalence of hypertension, and the results of interventions aimed at modulating both. Finally, it discusses current hypotheses on the mechanisms of selective pressure that may have favored the emergence of a salt-sensitive, hypertensive genotype. Similar to 'thrifty' genes, which supported energy savers in times of scarcity, but may now be causing obesity and type 2 diabetes, 'thirsty' genes, by acting on salt and water retention, might have helped individuals survive the challenge of volume-depleting illnesses, especially when combined with stress-inducing situations, but may now cause high BP and related damage in the post-reproductive age.
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PMID:Salt and hypertension: a phylogenetic perspective. 1575 81

An 81-year-old man, with chronic renal failure due to chronic glomerulonephritis on maintenance hemodialysis (HD) for 4.5 years, was admitted to our hospital because of rapidly developing hyperglycemia and hypertension. He had been under good control on HD with no history of hyperglycemia. One month prior to admission he felt thirsty and generally fatigued, but did not inform medical staff of his symptoms. We diagnosed him as suffering from autoimmune pancreatitis (AIMP) associated with secondary diabetes mellitus, according to the typical feature of AIMP on endoscopic retrograde cholangiopancreatography and an elevated level of serum immunoglobulin G4 (IgG4). He was treated with insulin and a corticosteroid, following which, the diffuse narrowing of the main pancreatic duct improved and his serum IgG4 level reduced. AIMP is a rare but important complication in HD patients that requires prompt diagnosis and treatment; we are therefore reporting on a unique complication in a chronic HD patient.
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PMID:A case report of autoimmune pancreatitis accompanied with rapidly developing hyperglycemia and hypertension in a chronic hemodialysis patient. 1738 37

A low salt diet is beneficial for the whole population but has particular advantages for hemodialyis patients because of the role of salt restriction in the management of hypertension and interdialytic weight gain (IDWG). Education on dietary salt intake based on general healthy eating guidelines, such as the "DASH-sodium" diet, should be provided for staff, families, and carers as well as patients. Anuric hemodialysis patients will need to take in approximately 1 l of water for every 8 g salt consumed. Patients who restrict salt intake to <6 g/day, and drink only when thirsty, should gain no more than 0.8 kg/day. Those with significantly greater weight gains, but predialysis serum sodium close to or higher than the dialysate sodium, need further review of their salt intake. Attempts to restrict fluid intake in these patients will be futile. Patients with high interdialytic weight gain (IDWG) and low predialysis sodium should be assessed for other reasons for fluid intake, such as high blood glucose or social drinking. For patients with poor tolerance of fluid removal during dialysis, and those who are hypertensive in the absence of fluid overload, a salt intake 5 g/day or less may be required. Dietary advice for these patients should be customized to ensure that they do not become malnourished.
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PMID:Reducing sodium intake in hemodialysis patients. 1957 6

Young generations of Saudi Arabia have adapted a culture of eating fast food items, which are rich in salt. Excess salt intake is a threat to cardiovascular functioning and risk for various cardiovascular diseases. The study, therefore, determines the prevalence and consumption of fast food, the level of physical activity, and the occurrence of hypertension among female students. A cross-sectional study design has been employed to include female students from the College of Arts and Science and Applied Medical Science Wadi Addawasir from January to April 2018. Chi-square/Fisher Exact test has been used for determining the occurrence of categorical variables. The questionnaire was intended to determine fast food habits prevalent among students. 97% of the students consumed fast food daily, 34% of the students were classified as prehypertensive, and 16.4% of the students were classified as hypertensive. Diastolic blood pressure was more compared to systolic blood pressure. Moreover, it was reported that 87% of the students knew the health effects of fast food. 58% of the students were not involved in physical activity and 49% of the students consumed soft drinks along with fast food. 70% of the students used table salt and 57% of the students felt thirsty after fast-food consumption. 55% of the students showed a positive response to the family history of hypertension. The findings have also shown a positive relationship between daily soft drink consumption and the incidence of prehypertension and hypertension among students. Increased consumption of salt-rich fast food, physical inactivity, genetic background of hypertension, prehypertensive and hypertensive conditions observed in the present study may expose to various cardiovascular diseases among the adult population in the future.
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PMID:Prevalence of salt rich fast food consumption: A focus on physical activity and incidence of hypertension among female students of Saudi Arabia. 3299 26