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Query: UMLS:C0020538 (hypertension)
 170,190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Plasma prolactin levels in women who were between 8 and 40 weeks pregnant were determined by a homologous double antibody radioimmunoassay method. There were 980 samples from 839 uncomplicated and 213 samples from 116 complicated pregnancies. Prolactin levels in normal pregnancies varied from 6 ng/ml during early pregnancy to 210 ng/ml near term. A few values beyond the normal range were found in various groups of complicated pregnancies. About 14 per cent of samples from patients with threatened abortion and 7 per cent from patients with hypertension were above the upper normal range. The proportion of values below the 10th centile in patients with a low urinary oestrogen excretion was significantly higher than that in the normal population. Plasma prolactin levels did not seem to be a valuable guide to maternal or fetal well-being.
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PMID:Plasma prolactin levels during pregnancy. 97 45

Prolactin adenomas seem rare in Dakar. Only 4 cases were confirmed by a series of 63 Intracranial Expansive Processes (ICEP) in the sella area recorded between 1972 and 1987 at Fann U.H.C Neurological and Neurosurgical Unit. These ICEP are dominated by craniopharyngiomas. From analysis of observations on four women aged between 20 and 38 years is may be concluded that: 1. Patients consult late for this amenorrhoea-galactorrhoea syndrome associated with intracranial hypertension and reductions in the field of vision. 2. On the paraclinical level: angiography reveals voluminous ICEP in the sella region with sub-sellar expansion; dosage with prolactinemia was only possible in 2 cases (of which 1 was post operational), which underlines the difficulties of carrying out this examination and its high cost despite its obvious usefulness in diagnosis and therapeutic supervision. 3. All operations were accompanied by histological study of the operational part which confirmed prolactinemia. Bromocriptine is the best medicine to be employed before or after the operation, and, in one case, allowed preoperational prolactinaemia to be reduced. 4. Classical X-rays of the skull centred on the sella turcica, and prolactinaemia medication for any amenorrhoea-galactorrhoea syndrome, should lead to a better understanding of the incidence of prolactin adenomas in this area.
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PMID:[Prolactin adenomas in Dakar]. 213 89

Prolactin has been involved in different types of hypertension both in man and in rats. In an attempt to substantiate this hypothesis, we have analysed the correlation between plasma concentrations of prolactin and systolic blood pressure (SBP) in female and male rats from spontaneously hypertensive (SH) and normotensive Wistar-Kyoto strains (30, 60 and 90 days old), as well as in adult female Wistar rats rendered hyperprolactinaemic by the administration of 100 micrograms testosterone propionate on day 1 of life, or adult males with low plasma concentrations of prolactin after administration of bromocriptine (4 mg/kg per day) over 15 days. Our results indicate a lack of correlation between plasma concentrations of prolactin and SBP since plasma concentrations of prolactin were normal in male and female SH rats and hyper- and hypoprolactinaemia did not affect SBP. In spite of these normal plasma concentrations of prolactin, SH rats showed subtle changes in the secretion of this hormone in vitro and in vivo in response to exogenous serotonin administration and to immobilization.
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PMID:Normoprolactinaemia in spontaneously hypertensive rats: absence of a close relationship between plasma concentrations of prolactin and systolic blood pressure. 237 81

Ketanserin, a serotonin-2-receptor antagonist, was administered to 12 subjects with mild to moderate hypertension in a randomized, double-blind, placebo-controlled crossover trial. After 6 weeks of ketanserin (40 mg every 12 h), blood pressures measured 12 h after dosing were not significantly different from those obtained during the placebo period. However, 2 h after ketanserin administration, supine systolic and diastolic blood pressures declined 11 +/- 10 mm Hg (p less than 0.01) and 6 +/- 5 mm Hg (p less than 0.005) from predose values, whereas placebo caused no change in either systolic or diastolic blood pressure. At the time of peak antihypertensive activity, plasma renin activity, aldosterone, growth hormone, and prolactin levels were unchanged. Prolactin levels decreased slightly (4.1 +/- 3.0 vs. 3.7 +/- 2.9 ng/ml, p less than 0.05) during ketanserin therapy when measured 12 h after dosing. Other pituitary hormones, serum testosterone, plasma catecholamines, and plasma lipids showed no changes. Heart rate was also unchanged. Stroke volume, measured 2 h after dosing, increased (70 +/- 22 vs. 85 +/- 31 ml, p less than 0.05) with ketanserin therapy, but cardiac output did not change significantly. Ketanserin has a moderate antihypertensive effect and neutral metabolic-hormonal profile when used as monotherapy for the treatment of hypertension. However, further studies are needed to define the frequency of dosing that will provide 24-h antihypertensive activity.
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PMID:Antihypertensive therapy with ketanserin: metabolic and hemodynamic effects. 246 37

In 106 pregnant women (32-41 gestation weeks) prolactin values were determined in the sera of mothers and fetuses and in the amniotic fluid by the radioimmunological method in m IU L. Four group of parturients and their newborns were examined: Group I (n = 18) contained parturients with hypertensive disease and pre-term delivery, group II (n = 27) parturients with pre-term delivery, group III (n = 25) parturients with hypertensive disease and at-term delivery, and group IV (n = 36) normal parturients with at-term delivery. Prolactin values (mean +/- SD) in the serum of parturients with pre-term delivery (group I 8,311 +/- 2,654 and group II 8,203 +/- 2,647) and in those with at-term delivery (group III 9,656 +/- 3,145 and group IV 9,873 +/- 3,062) showed no significant differences (p greater than 0.05). Prolactin values in the serum of the umbilical cord artery proved significantly higher (p less than 0.05) in parturients with pre-term delivery (group I 11,598 +/- 2,923, group II 9,632 +/- 3,009) and at-term delivery (group III 13,266 +/- 3,015, group IV 11,243 +/- 3,123) in hypertension-affected women. A significantly higher (p less than 0.01) prolactin value was recorded in the amniotic fluid of parturients with pre-term delivery (group I 23,367 +/- 3,896, group II 19,715 +/- 4,128) and at-term delivery (group III 22,755 +/- 4,938, group IV 18,638 +/- 4,724) affected by hypertensive disease. The difference between the prolactin level in parturients with the meconium and clear amniotic fluid (22,059 +/- 5,465 and 19,263 +/- 5,673) was not significant (p greater than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Prolactin in the serum of mothers and neonates and in the amniotic fluid of pregnant women with hypertensive disease]. 260 73

Prolactin may play an important role in the pathogenesis of pregnancy-induced hypertension (PIH) and preeclampsia. In 105 normotensive nulliparous women at 28 to 32 weeks of gestation, the relationship between serum prolactin concentration (PRL) and blood pressure behaviour was examined under standardized conditions. Neither postural change from left lateral to supine recumbency nor the infusion of low doses of angiotensin-II-amide had an effect on PRL levels. Similar mean PRL levels were found in pregnant women with a low angiotensin pressor dose (ADP less than 10 ng x kg-1 x min-1) or "angiotensin sensitivity", a positive supine pressor response (delta pd greater than or equal to 20 mmHg) or an increased serum uric acid concentration (greater than 3.6 mg/dl), which are criteria for an increased risk of developing hypertensive complications. However, in the group of subjects with angiotensin sensitivity, a significant correlation was found (a) between PRL levels and the APD and (b) between PRL levels and diastolic blood pressure increase after 5 min of supine recumbency. These results may reflect diminished dopaminergic activity in the central nervous system, which could influence both blood pressure and prolactin secretion.
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PMID:Relationship between serum prolactin concentration, vascular angiotensin sensitivity and arterial blood pressure during third trimester pregnancy. 340 Oct 43

In the present studies, the content and the in vitro production of prolactin by decidua as well as the concentrations of prolactin in amniotic fluid, maternal and fetal serum in normal term pregnancies, induced abortions at various gestational ages, and in pregnancies complicated by diabetes mellitus, preeclampsia, chronic hypertension, and polyhydramnios were measured. Maternal and fetal prolactin levels varied considerably throughout gestation, but at term did not differ significantly between normal and abnormal pregnancies. Prolactin levels in amniotic fluid as well as decidual prolactin content and production were significantly lower only in pregnancies complicated by either hypertension or polyhydramnios. In both normal and abnormal pregnancies, decidual prolactin production correlated strongly with amniotic fluid concentrations. The present data suggest that 1) maternal and fetal prolactin levels do not differ significantly between normal and abnormal pregnancies, 2) the decidua is the principal source of amniotic fluid prolactin, and 3) the significantly lower levels of prolactin in amniotic fluid of pregnancies complicated by hypertension or polyhydramnios are probably due to adverse effects of these conditions on the synthesis and release of prolactin by decidua.
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PMID:Decidual, amniotic fluid, maternal and fetal prolactin in normal and abnormal pregnancies. 636 59

A prospective, cross-sectional study of 164 primigravid patients was conducted to determine the role of prolactin in the pathogenesis of pregnancy induced hypertension. Clinically normal patients had peripheral venous blood sampled from the lateral and recumbent positions monthly in the morning during their last two trimesters in labor and six weeks postpartum. One-third of the patients had 24 hour urine collections. Homologous double antibody radioimmunoassays were performed to determine prolactin levels. The data were analyzed according to pregnancy outcome: pregnancy-induced hypertension or normotensive throughout pregnancy. Acute positional change did not influence prolactin level. Prolactin levels were significantly elevated in the hypertensive outcome group only at 37-39 weeks and were not correlated with sodium excretion. We conclude that circulating prolactin does not play a significant role in pathogenesis of pregnancy-induced hypertension, but perhaps the elevated levels may be reflecting pathophysiologic changes.
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PMID:A prospective study of circulating prolactin during primigravid pregnancy. 718 65

1. In an attempt to test the hypothesis of a derangement in central catecholaminergic function in hypertensive patients, the serum growth hormone and prolactin responses to the alpha-adrenergic agonist clonidine (0.15 mg infused intravenously) and to L-dopa administration (500 mg orally) were evaluated in 15 hypertensive and 15 normotensive subjects matched for sex, age and body weight. 2. Whereas L-dopa elicited a growth hormone response of similar magnitude in both groups, clonidine infusion induced a significant increase in serum growth hormone in normotensive, but not in hypertensive, subjects. 3. Prolactin levels were equally suppressed by L-dopa and did not change after clonidine in either group. 4. The present study adds neuroendocrine evidence to the concept of a derangement in central alpha-adrenergic function in human hypertension.
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PMID:Growth hormone secretion in hypertensive patients: evidence for a derangement in central adrenergic function. 735 32

Prolactin concentrations were measured in mixed cord blood of 782 newborn infants and related to the occurrence of the respiratory distress syndrome (RDS) and maternal cardiovascular condition. Infants of 30 to 33 weeks' gestational age who developed RDS had significantly lower serum concentrations of prolactin than non-RDS infants within this same age range. No difference was observed between RDS and non-RDS infants at 34 to 36 weeks. Prolactin levels in infants delivered by preeclamptic women were greater than the levels in infants of normotensive women from 30 to 39 weeks' gestation. The levels were higher in the 40 to 42 weeks age group as well; however, the difference was not statistically significant. Infants of mothers with gestational hypertension also tended to have elevated serum prolactin concentrations. No differences were observed in infants of women presenting with a history of chronic hypertension. Within the RDS subgroups, serum prolactin levels were significantly greater in infants of preeclamptic women than in infants of normotensive women, being approximately equal to the levels in the non-RDS normotensive group.
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PMID:Relationship of newborn serum prolactin levels to the respiratory distress syndrome and maternal hypertension. 738 51


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