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Query: UMLS:C0020538 (hypertension)
 170,190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

To study the value of magnetic resonance imaging (MRI) in the determination of heart morphology and function, 47 patients with malignant arterial hypertension (MAH) were examined. The images of the both ventricles, ventricular septum (VS), left ventricular (LV) apex and posterior wall (LVPW), aortic root and left atrium were studied. In all the patients, symmetric LV hypertrophy was found and the thickness of LVPW was 1.46 cm, IVS, 1.53 cm. The heart chambers were not enlarged. The diameter of aortic root was 3.36 cm. There was a close correlation between LV hypertrophy and blood pressure. We conclude that the development of LV hypertrophy in MAH is not merely a compensatory process response to high blood pressure.
Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR 1989
PMID:[A MR tomographic method for studying heart function in malignant arterial hypertension]. 253 16

The increased body mass (Quetelet index greater than or equal to 30.0) in 1447 autopsies of Riga's male population aged 20-59 years was revealed in 8.6% of all cases. A significant rise of mean values of the Quetelet index was found in the presence of arterial hypertension, hypercholesterolemia, increased thickness of subcutaneous fat and diabetes mellitus. The mean value of the Quetelet index was significantly higher in cases of coronary and cerebrovascular death victims than that seen in the 20-59-year old group and apparently healthy persons.
Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR 1989
PMID:[Quetelet's index in the male population aged 20 to 59 (epidemiological autopsy research in Riga)]. 260 89

The therapeutic efficacy of guanfacine was investigated in a group of 32 hypertensive patients. Guanfacine caused a marked decrease in total peripheral vascular resistance (by 19.8%, p less than 0.001) and, hence, in blood pressure (by 19.4%), p less than 0.001). A slight reduction in the heart rate (by 9.8%, p less than 0.01) was compensated by an increase in stroke volume (by 11.8%, p less than 0.05) so that cardiac output remained constant or was even slightly raised. After 4 weeks of treatment there was a regression of the left ventricular wall thickness and mass (by 7.43 +/- 2.44 g, p less than 0.05). Guanfacine monotherapy was effective in 75% of patients with moderate hypertension (using low doses 1-3 mg/day). In severe hypertensive disease a satisfactory therapeutic response was mostly achieved by a combination of Guanfacine (3-5 mg/day) with a beta-blocker, diuretic or vasodilator. Guanfacine is a promising agent in the long-term treatment of stable hypertension, particularly in patients, whom diuretics or beta-blockers are contraindicated.
Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR 1989
PMID:[Hypotensive and hemodynamic effects of guanfacine in arterial hypertension]. 266 29

Results are reviewed of the studies concerning genetics of hypertension. Evidence is provided for its genetic determination of the disease and biochemical control of blood pressure by the renin-aldosterone-angiotensin system. Approaches to the therapy and prevention of hypertension are proposed on the basis of own clinical and population studies. The methods are discussed to study genetics of hypertension using genetic markers.
Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR 1989
PMID:[Genetic research in hypertension]. 269 Aug 64

Combination of chronic salt loading with protein-poor diet produces experimental hypertension with natrium consumption near to physiological. The present model is characterized, compared to the existing one, by stage development, moderate arterial blood pressure elevation and absence of "salt toxicosis" and may be thus considered more adequate for experimental investigation of primary arterial hypertension pathophysiology.
Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR 1989
PMID:[Modeling of experimental hypertension by chronic salt loading combined with a low-protein diet in Wistar rats]. 274 63

Circadian variations of blood pressure (BP) in dependence on neurogenous baroreceptor control in patients with essential hypertension (EH) or renovascular hypertension (RH) were studied. Patients with EH demonstrated significantly greater decrease of systolic as well as diastolic BP at night compared to those with RH. Circadian variation rates of systolic and mean BP were also higher in patients with EH. Baroreceptor test exhibited higher cardiochronotropic effect in patients with EH. They had also negative correlation between BP variation rates and BP reaction to baroreceptor test which is absent in patients with RH. The data obtained suggest that neuroregulation mechanisms have less effect on BP level in RH than in EH.
Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR 1989
PMID:[Circadian variability of arterial blood pressure and the baroreceptor reflex in patients with arterial hypertension of various etiologies]. 274 65

184 patients with arterial hypertension (AH) were studied. 63 of them had essential hypertension, 49 had renovascular hypertension, 27 had Leriche's syndrome, 38 had aortal aneurysms and 7 had coarctation of aorta. MR-tomography (MRT) gave satisfactory enough findings in diagnosis of vascular pathology in patients with essential hypertension as well as in those with symptomatic hypertensions of vascular origin. Criteria for assessment of vessels state and symptoms of various types of vascular pathology, such as stenosis and aorta aneurysm, were developed. In essential hypertension MRT may show early aortic alterations and dependence of their degree on duration and severity of the disease. The method makes it possible to assess the state of inner organs simultaneously with the investigation of the vessels which is of great importance for the patients to whom surgical treatment is recommended.
Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR 1989
PMID:[Examination of the aorta and major arteries in arterial hypertension using MR tomography]. 274 66

99 patients with arterial hypertension (AH) were studied: 17 patients with pheochromocytoma, 37 with aldosteronoma, 4 with corticosteroma, 38 with essential hypertension. Control group included 16 healthy subjects. The investigation was performed by means of a NMR-tomograph BMT-1100 ("Brucker", FRG) in axial and frontal planes according to Spin Echo (SE) technique with TR = 2.0 s, TE = 34 ms. Qualitative (visual) as well as quantitative criteria for evaluation of adrenal glands state were developed. Normal size of adrenal glands, relative intensity of their signal and T2 were calculated. The data obtained proved that relative intensity of the signal is a highly informative parameter for differential diagnosis of adrenal gland tumors (its value of less than 1.0 is evidence of cortex lesion, and that of more than 1.4--of medulla lesion). High informative value of MR-tomography for evaluation of adrenal glands state in patients with AH is proved by comparative data obtained by other methods, such as computer tomography aortography and histomorphology.
Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR 1988
PMID:[Clinical use of magnetic resonance tomography for assessing adrenal function in patients with arterial hypertension]. 285 44

Electro- (12 and 35 ECG leads) and vectorcardiographic (3 orthogonal leads) examination of 75 patients with arterial hypertension and left-ventricular hypertrophy (LVH), 28 of which also had documented stenosis of one or more coronary arteries, was carried out using an automatic system of graphic registration and quantification of ECG-35 and VCG parameters. Electro- and vectorcardiographic signs of "pure" LVH and LVH accompanied by CHD relevant for their differential diagnosis were established. The principal singled out difference criteria include NQ (Q registration zone) and SQRSxyz (space QRS loop area), while Q (Q-wave sum), H0QRSxyz 0.08-0.10 s (QRS end vector azimuth), Gxyz (space ventricular gradient) and V0Gxyz (ventricular gradient elevation) are complementary, determined by the degree of the principal parameter shifts.
Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR 1986
PMID:[Approaches to electro- and vectorcardiographic differentiation of the signs of focal and cicatricial myocardial lesions in left-ventricular hypertrophy]. 293 52

721 cases of sudden coronary death (SCD) of men aged 30-59 were studied. It was found out that SCD happened in majority of cases in subjects with increased weight of heart: 44.2% of patients had heart weight of 500 g or more. A special histomorphometric study of kidneys (345 cases of SCD) revealed arterial hypertension (AH) in 41.2% of cases, which far exceeded AH incidence in the population of men of equal age. Nevertheless, not in all cases of SCD was myocardial hypertrophy caused by AH. In patients with no AH myocardial hypertrophy was usually caused by postinfarction cardiosclerosis. In certain cases of SCD without cardiosclerosis accompanied by manifest myocardial hypertrophy there were signs of dilatative or hypertrophic cardiomyopathy. The obtained results suggest that AH and increased weight of heart should be considered factors predisposing to SCD.
Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR 1988
PMID:[Myocardial hypertrophy, arterial hypertension and sudden cardiac death]. 296 34


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