Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0020538 (hypertension)
 170,190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Three classifications: of the American College of Obstetricians and Gynecologists (ACOG), of the Organization of Gestosis (OG) and of the International Society for Study of Hypertension in Pregnancy (ISSHP) differ among one another in some essential points. According to ACOG the term "preeclampsia" means a state with hypertension and albuminuria or edema, according to ISSHP--hypertension and albuminuria. This may lead to serious misunderstanding as many obstetricians use this term to identify a directly threatening eclampsia attack. But the two classifications do not provide a term for such a condition whereas according to OG this state is identified as threatening eclampsia. The OG and ACOG classifications give a classifications according to the progression of the disease, the ISSHP does not give such a classification. ISSHP does not consider edema as a symptom, ACOG takes it into consideration if it is accompanied by hypertension according to OG the very edema not subsiding after relaxation is enough to diagnose gestosis E. ISSHP has introduced the term "hypertension in pregnancy", but also includes one-symptom form "pregnancy albuminuria" not accompanied by hypertension. Such terms suggest lack of etiological relation between those forms, which has not however been proved. The names of one-symptom forms according to OG "gestosis H" and "gestosis P" do not impose such a relation (it is a classification according to symptoms), but they do not exclude it. Contrary to ACOG and OG, ISSHP gives the level of diastolic blood pressure only.
 ...
PMID:[3 classifications of gestosis]. 257 48

Gestosis index score at delivery was compared with factors reflecting the fetal development in a series of 95 patients with EPH-gestosis collected in Okayama University Medical School in 1975-1979. The prediction of small for date (SFD) was performed by means of multivariate analysis of 10 variables, i.e. gestosis index, maternal body weight, height, uterine fundal length, abdominal circumference, maternal age at delivery and urinary estriol within one week prior to delivery. The result was that gestosis index was as useful as uterine fundal length in predicting SFD. The more gestosis index score increased, the more markedly the fetal development ws disturbed. Especially in the cases with scoring above 4 and in those with hypertension and proteinuria, the incidence of SFD increased obviously. No correlation between gestosis index and neonatal asphyxia was noticed. From the growth pattern of uterine fundal length and BPD, intrauterine growth retardation (IUGR) in pregnancy with EPH-gestosis occurred mainly within the third trimester of pregnancy. The functional development of the fetus with EPH-gestosis was evaluated with the use of urinary estriol level and fetal heart rate (FHR) monitoring. In the cases with EPH-gestosis scoring above 4, extreme disturbance of functional development of the fetus was observed.
 ...
PMID:Estimation of gestosis of pregnancy (EPH-gestosis), relationship between fetal development and gestosis index. 719 59

For hypertensive disorders of pregnancy there are not only a lot of terms and trials for classification--but also the definition of hypertension as the leading sign is unclear. This explains the confusion around this meaning-full problem. The International Society for the Study of hypertension in Pregnancy (ISSHP) submitted proposals for a new terminology and classification of hypertensive disorders in pregnancy. The members of the ISSHP's German Section and the German Study group for Hypertension in Pregnancy/Gestosis simplified this new ISSHP-proposal and adapted it to the peculiarities of German language. This new concept is presented and recommended for use in medical practice.
 ...
PMID:[The new terminology and classification of hypertensive diseases in pregnancy]. 814 90

Essential edema-proteinuria-hypertension (EPH) gestosis still represents an important obstetrical problem. We have investigated the activity of carboxypeptidase H (CPH), phenylmethylsulfonyl fluoride inhibited carboxypeptidase (PMSF-CP), carboxypeptidase M (CPM) and angiotensin-converting enzyme (ACE), the main carboxypeptidases in human placenta under normal conditions and mild EPH-gestosis. Gestosis was accompanied by the decrease in activity of the enzymes involved into metabolism of regulatory peptides (ACE, CPH, PMSF-CP, CPM) compared with their activity in placenta under physiological pregnancy. Correlation analysis revealed positive correlation between placental CPH and CPM (r = 0.2735*) in EPH-gestosis. These findings suggest involvement of placental proteases into formation of compensatory-adaptive reactions in the fetoplacental complex at EPH-gestosis; the data obtained may be also employed for the development of methods of prophylaxis and corrections of metabolic impairments in pathology of pregnancy.
 ...
PMID:[Proteolytic activity of placenta with EPH-gestosis]. 2001 98