Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020538 (hypertension)
 170,190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

There have been many new published articles on the association between oral contraception (OC) and carcinogenic effects. Risk of benign breast cancer seems to be about 3/1000 in women under OC treatment. According to a study by the Royal College of General Practitioners this decrease is in proportion to the dose of progesterone used. Incidence of malignant breast cancer in OC users varies greatly; it is about 13/100,000 in Japan and 71.4/100,000 in the U.S.: the influence of the environment seems to be as responsible for side effects as genetic and obstetrical factors. Risk of malignant endometrial cancer is increased by age over 40, obesity, and nulliparity. However, since 1975, there has been an increase in the reported incidence of endometrial adenocarcinoma in young women. There is only 1 published study which shows that OC may decrease endometrial effects in OC users. Cervical pathology in OC users includes endocervical polypus, which are asymptomatic, and dysplasia and carcinoma, which are both related to age at 1st sexual encounter and to the number of sexual partners. The incidence of hepatic carcinoma in relation to OC is only 1/50,000. Risk of thromboembolism and hypertension are increased by age over 35, obesity, smoking, and family or antecedent history of cardiovascular problems.
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PMID:[Risks and follow-up of women taking combination oral contraceptives]. 1227 53

Endometrioid endometrial adenocarcinomas (EECs) are frequent genital tumors for which the clinical, imaging and histopathological integrated analysis is the basis of differential diagnosis and therapeutic attitude. This research represents a tertiary multicenter study including 58 cases examined histopathologically and immunohistochemically, surgically treated, on a five years period. The main characteristics of the patients in the study group are represented by the average age of 66 years, associated with obesity, hypertension, diabetes, history of infertility, early menopause, nulliparity or long-time oral contraception. The most important clinical sign was the menopausal or postmenopausal vaginal bleeding. The golden standard in the diagnosis of endometrial carcinoma is the dilation and curettage of the uterine cavity, followed by histopathological assessment. The association between transvaginal ultrasonography (TVUS) and endometrial biopsy increases to 100% the diagnostic sensitivity. The use of an antibodies panel that includes CK, ER, PR, vimentin can guide the diagnosis to EEC and the analysis of Ki67, p16, p53 and CEA immunoreactions can be useful both for EEC differential diagnosis and to assess the tumor aggressiveness. The interrelation between the accurate histopathological diagnosis and the adequate surgical staging is the cornerstone of curative therapy in the EEC.
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PMID:Morphological, imaging and surgical aspects in endometrial endometrioid adenocarcinoma. 2800 15


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