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Query: UMLS:C0020538 (hypertension)
 170,190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Four Black South African patients, representative of a larger group, are described in detail. The common features were long periods of observation, multiple hospital admissions in both normotensive and hypertensive cardiac failure, hypertensive retinopathy and good renal function. All had been diagnosed as having cardiomyopathy. Two of the patients in a normotensive phase became hypertensive after responding to therapy for heart failure. One patient with malignant hypertension showed the features of idiopathic cardiomyopathy at necropsy. These cases are regarded as evidence in favour of the hypothesis that many cases of cryptogenic heart disease (cardiomyopathy, congestive cardiomyopathy, idiopathic cardiomegaly) are in fact cases of hypertension presenting with normotensive cardiac failure.
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PMID:Hypertensive heart disease and cardiomyopathy in blacks. Diagnostic confusion. 45 82

Valuable information was collected on the medical history and clinical course of 1273 patients entered in clinical trials with Adriamycin (ADR) carried out in 12 European cancer centers. A coded patient form was used for the data collection carried out in each center by a qualified physician following a guideline which was discussed and accepted by all of the participants. The aim of the study was to define the incidence, characteristics, and possible co-factors of the cardiomyopathy (CMP) in patients treated with combination chemotherapy regimens including ADR. The mean total dose of ADR was 268 mg/m2 (range, 15--1251 mg/m2), and 5.1% of the patients received a total dose of greater than 550 mg/m2. A "definite" ADR-related CMP was observed in 1.7% of the cases; another 3% of the cases were reported as "possible" ADR-CMP since the role played by the drug could not be clearly defined. "Definite" ADR-CMP was fatal in eight patients (0.6%) while "possible" ADR-CMP was fatal in 13 patients (1.0%). Among the possible co-factors examined, the following ones were found to be significantly associated with the occurrence of a "definite" ADR-CMP: (a) total dose of ADR; (b) vincristine when given both before and concomitantly with ADR; (c) bleomycin when given before ADR; and (d) radiotherapy to the mediastinum when given concomitantly with ADR. Furthermore, none of 182 patients receiving ADR by slow infusion developed a "definite" ADR-CMP, while 2% of the patients treated by bolus injection did so. The occurrence of a "possible" ADR-CMP was found to be significantly associated with two pre-existing pathologic conditions (electrocardiogram [ECG] abnormalities and hypertension) but not with the treatment-related co-factors for the "definite" ADR-CMP mentioned above. Other variables examined, such as sex, age, cancer type, baseline liver function, and cyclophosphamide treatment, did not seem to influence the risk of ADR-CMP. Data on ECG changes occurring during ADR treatment were also reported and their incidence was found to be strictly related to the frequency of the ECG monitoring.
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PMID:Adriamycin cardiotoxicity: a survey of 1273 patients. 45 24

The aim of this study was to evaluate the usefulness of M-mode echocardiography as a non-invasive diagnostic tool when facilities for cardiac catheterization were not available. We used this technique to study 275 patients whose clinical diagnosis included hypertension, rheumatic heart disease, cardiomyopathy, peripartum cardiac failure, pericardial disease and some forms of congenital heart disease. Characteristic echocardiographic patterns made specific cardiac diagnoses possible and allowed a distinction to be made between clinically similar conditions. It is concluded that echocardiography is very useful in the African setting because it is safe and repeatable.
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PMID:M-mode echocardiography in the diagnosis of heart diseases in Africans. 55 66

This case report documents the co-existence of valvar aortic stenosis and hypertrophic obstructive cardiomyopathy with systemic hypertension and calcific mitral annulus, a combination which has not hitherto been reported. It is the purpose of this paper to help assess the true incidence of the co-existence of aortic stenosis and hypertrophic cardiomyopathy.
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PMID:Valvar aortic stenosis with unusual features. 56 Jun 91

A case of combined hypertrophic obstructive cardiomyopathy and mitral annular calcification is reported. The characteristic features of both entities were clearly demonstrated by thorough noninvasive examinations. It is proposed that the association of the two conditions is not coincidental but that mitral annular calcification, by narrowing of the left ventricular outflow tract, can result in the development of hypertrophic obstructive cardiomyopathy. Mitral annular calcification should possibly be added to the other causes of pressure overload of the left ventricle--such as hypertension and valvular or discrete subvalvular aortic stenosis--as a potential etiology of secondary hypertrophic obstructive cardiomyopathy.
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PMID:Coexistence of hypertrophic obstructive cardiomyopathy and mitral annular calcification: proposed etiologic relationship. 57 64

Examinations were carried out on the frequency of the occurrence of myocardiopathy and arterial hypertension in 492 miners and 175 manual workers employed on mines surface. Physical symptoms of cardiac muscle degeneration were found in 7,3%, electrocardiographical symptoms in 11,1%, whereas in 9,9% miners hypertension was found. No significant difference between the frequency of these diseases in pit miners, as compared with those manual workers working on the surface of the mines, was found.
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PMID:[Myocardiopathy and arterial hypertension in coal miners in the Rybnik region]. 59 39

Isovolumic relaxation time (IVRT) was determined in 17 controls and 41 patients. Nine patients had ischemic heart disease (IHD), 7 mitral prolapse (MVPS), 13 hypertension (HPB), 7 pregnancy (P), and 5 cardiomyopathy (CM). Echocardiographic measurements of IVRT were made from the aortic second sound to the rapid opening of the mitral valve (A2D1). Determinations by apexcardiography were made from the aortic second sound to the 0 point (A2O). The IVRT was distinctly shorter when assessed by A2D1 than by conventional apexdardiography in conventional apexcardiography in controls (69.2 +/- 16.4 msec vs 118.7 +/- 16.5 msec) and in patients with cardiac disease. The IVRT in 9 older normal controls (mean age 47.7 years) was longer than in 8 younger ones (age 26.3 +/- 4.9 years). Patients with myocardial disease (IHD, HBP, and CM) had prolonged IVRTs when compared to normal subjects. Pregnant subjects had shortened intervals. IVRT may be a sensitive indicator of disturbances in myocardial contractility and may be shortened and enhanced contractility.
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PMID:Isovolumic relaxation time in normal subjects and patients with cardiac disease: comparison of determinations made with echocardiographic techniques and apex cardiography. 62 24

A working classification of noncoronarogenic damage to the cardiac muscle is suggested in which 4 general-pathology groups are considered: myocardial dystrophies, myocarditis, cardiomyopathy, and neoplasms. The main principles are presented for grouping diseases of the myocardium not associated with ischemic heart disease, hypertension or rheumatic fever. Certain problems of the clinical picture and differential diagnosis of dystrophic, inflammatory, and idiopathic damages to the heart muscle are discussed.
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PMID:[Classification of non-coronarogenic myocardial damage]. 67 84

Examination of the cardiovascular apparatus (cv) of 25 acromegalic patients revealed an increased incidence of cardiovascular pathology as against normal individuals. Acromegalic patients with arterial hypertension (AH) show a twice higher incidence of ischemic cardiopathy, cardiomegaly with obvious or latent cardiac failure, arrhythmias, which frequently lead to death. The uncertain pathogeny of cardiomyopathy implied: hypoxia due to heart hypertrophy (over 500 g and increased cross-section of the fibre to over 26/mu), adrenergic deficiency resulting from increased protein synthesis and decrease in thyrosine, a precursor of myocardic cathecolamines. The increased incidence of coronary pathology is favoured in acromegalic patients by diabetes, hyperlipoproteinemia, low endogenous heparin, increased ureic acid and platelet adhesivity. Hypophysectomy by hypophysolysis (20 cases) brings relief and cures cardiovascular pathology, reduces AH, corrects the coronary risk factors, cures hypophyseal diabetes. The existence of AH and cardiovascular pathology is an indication for surgical treatment in evolutive acromegaly.
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PMID:Cardiovascular pathology in acromegaly and some effects of the 90 yttrium implant in the hypophysis. 69 1

The diagnosis of primary dilated cardiomyopathy depends on the recognition of a dilated poorly contracting left ventricle with increased end-diastolic and end-systolic volumes in the absence of a detectable cause. The diagnosis is made only after exclusion both of structural heart disease and of known causes of secondary heart muscle disorder. The natural history is still largely unknown and is probably as variable as the likely causes. The left ventricular disorder does not cause symptoms until heart failure supervenes except for occasional patients who develop an early atrial or ventricular dysrhythmia, conduction defect, chest pain or murmur of mitral regurgitation. This period of latency may be short, prolonged or even permanent since it is unlikely that all cases progess to the point of failure. A few patients recover normal or near-normal cardiac function. The interplay between high blood pressure, hypertensive heart failure and dilated cardiomyopathy is illustrated by patients who recover from heart failure to become hypertensive and vice versa and in current treatment with vasodilators and diuretics for patients at either end of the spectrum.
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PMID:Diagnosis and natural history of congested (dilated) cardiomyopathies. 70 14


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