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Query: UMLS:C0020538 (hypertension)
 170,190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Of 409 patients attending a clinic for control of hypertension, 74 (18%) were found to have haematuria, and all those with haematuria had significant renal impairment. The association of raised serum IgA levels and HLA BW35 in these patients suggests that some have the adult form of the IgA/C3 disease described in children.
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PMID:Significance of haematuria in hypertensive patients. 610 80

A series of 58 patients of aortitis syndrome were analyzed from the standpoint of the pathogenesis and surgical treatment. Investigations of HLA revealed a high incidence of HLA-A9, BW52, MT1 and DR2 antigens with statistically significant differences in the chi-square test. These data indicate that a haplotype composed of A9, BW52, MT1 and DR2 is common in patients with aortitis syndrome and suggest that a genetic factor plays an important role on the pathogenesis of the disease. Experiences with the surgical treatment of various types of aortitis syndrome, such as operation for cerebrovascular insufficiency (7 cases), for hypertension produced by coarctation or renovascular stenosis (14 cases), for aortic regurgitation (2 cases), and for aneurysm (7 cases) were analyzed. Reconstructive surgery is difficult in many of them because of the complicated lesion produced by inflammatory changes. Attention should be paid to the selection of the most suitable time for operation, application of special surgical technique, and prevention of the complications to obtain favorable results.
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PMID:Pathogenesis and surgical treatment of aortitis syndrome. 617 99

Thirty-six patients received allogeneic (34) or syngeneic (two) bone marrow transplants as treatment for severe aplastic anaemia or acute leukaemia. Nineteen of the allogeneic recipients received methotrexate (MTX) and 15 received cyclosporin A (CyA) as the predominant immunosuppressive agent to minimize graft-versus-host disease (GVHD) post transplant. In the first 100 d post transplant renal dysfunction was much less frequent in the MTX recipients than in the CyA recipients who exhibited three distinct syndromes of nephrotoxicity: most commonly. CyA recipients developed asymptomatic azotaemia, proteinuria, urinary casts, impaired urinary concentrating ability and hypertension. Secondly, two CyA recipients developed acute reversible renal failure precipitated by systemic bacterial infection which required dialysis and in which the kidney was the sole target organ; thirdly, two recipients of HLA-genotypically non-identical grafts developed a rapidly progressive fatal syndrome with multiple organ involvement including lung, brain and kidney which clinically and histologically resembled thrombotic thrombocytopenic purpura.
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PMID:Cyclosporin A associated nephrotoxicity in the first 100 days after allogeneic bone marrow transplantation: three distinct syndromes. 634 55

IgA-glomerulonephritis (IgA-GN) accounts for approximately 20 per cent of all glomerulonephritis in our unit. Seventeen out of 50 patients with IgA-GN developed renal failure, which appeared in 11 out of 17 over the course of a mean follow-up of 68 months. Haemodialysis was required in three patients. Twenty-two out of 50 patients had hypertension, five with malignant hypertension. Perivascular IgA deposits were found in skin biopsies of 29 per cent of patients with IgA-GN and also in 19 per cent of patients with other GN, but not in healthy controls. Mucosal (salivary and nasal) secretory IgA concentrations were normal. In cutaneous and glomerular IgA/IgM deposits, IgA1 was demonstrated using monoclonal antibodies. No excess of HLA-A, B or DR antigens and no relation of clinical course and HLA-Bw35 were found.
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PMID:Clinical and serological features of mesangial IgA glomerulonephritis. 634 57

There is now increasing evidence for immunological changes in essential hypertension. Immunological response is determined in part by genes linked to the HLA system. It has been reported a positive association between HLA B15 and the risk for cerebral events in essential hypertensive (EH) patients. We studied the distribution of HLA antigens in 128 EH (age range, 13-85 years) and 1000 normotensive controls. EH were classified in accordance with the World Health Organization (WHO) criteria: in WHO Stages I and II, there were 100 patients; in WHO Stage III, there were 28 patients. HLA-A and B antigens of peripheral blood lymphocytes were studied according to the microlymphocytotoxicity test. The results were compared by chi-square analysis, and the p value was multiplied by the number of antigens studied at each locus, to avoid overestimation of an association. Frequency of HLA-BW 22 was higher in EH compared with controls (5.4% vs 1.2%, p less than 0.01). Frequency of HLA-B12 in EH with WHO Stage III hypertension (64.2%) was significantly increased compared either with EH in WHO Stage I or II (29%, p less than 0.01) or the control group (26.9% p less than 0.001). The incidence of HLA-B15 antigen in the whole hypertensive group was 3.1%, lower than in normotensive controls (6.4%, p less than 0.8). None of the patients with WHO Stage III hypertension had the HLA-B15 antigen. In conclusion, the results seemed to indicated that the Spanish population had an association between HLA-B12 and severe hypertension.
Hypertension
PMID:Severe hypertension in the Spanish population. Association with specific HLA antigens. 658 Nov 25

Two brothers, aged 20 and 12, with the 11 beta-hydroxylase deficient form of congenital adrenal hyperplasia, are presented. They had refused treatment for the previous four years until the younger was admitted with malignant hypertension, partial blindness and evidence of myocardial damage. The elder was therefore admitted for assessment and found to have less severe hypertension. Gas liquid chromatographic analysis of the steroids in urine from each revealed a possible difference in the enzyme defect between the two brothers--the younger having a complete, while the elder had only a partial block. Family studies have confirmed no association with the HLA locus.
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PMID:Malignant hypertension in congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency. 660 91

Anticentromere antibody (ACA) was found in the serum of 4 (3%) of 120 patients with progressive systemic sclerosis with diffuse scleroderma and in 69 (49%) of 141 with progressive systemic sclerosis with the CREST syndrome variant. The 69 CREST syndrome patients with ACA were compared with the 72 CREST syndrome patients without ACA. The former were older at the onset of symptoms and significantly more frequently female (97% versus 78%, P less than 0.01). Those with ACA more often had telangiectasiae of the digits (93% versus 75%) and calcinosis (55% versus 22%). These differences were also present after the groups were stratified according to duration of disease. Cutaneous involvement was similar in both degree and extent in the 2 groups; 20% of CREST patients both with and without ACA had forearm skin thickening. Pulmonary interstitial fibrosis on chest roentgenogram and restrictive disease on pulmonary function testing were significantly less frequent in the ACA patients. Gastrointestinal involvement, pulmonary arterial hypertension, and cardiac abnormalities were similar in both groups, and there has been no difference in survival between CREST syndrome patients with and without ACA. Tissue typing studies revealed a significant association between ACA and HLA-DR1.
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PMID:Clinical and laboratory associations of anticentromere antibody in patients with progressive systemic sclerosis. 660 34

In 200 patients with myocardial infarction, 35 of them with concomitant insulin-independent diabetes mellitus, 91 - with hypertension and 91 - without diabetes and hypertension, it was established that the patients with diabetes and hypertension manifected an association with HLA-BW, whereas sucr association was not observed in infarction group without hypertension and diabetes.
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PMID:[Association between the HLA system and myocardial infarct]. 664 89

A prospective study of 54 primigravid twin pregnancies in Durban showed that pregnancy-induced hypertension occurred in 37%. This was more than twice the expected rate for singleton pregnancies in this Black African population. The babies born in the group of patients with pregnancy-induced hypertension were significantly lighter and had a higher rate of fetal growth retardation than the babies born in a normotensive control group of patients matched for age and parity. Monozygotic twins, identified by HLA typing, occurred significantly more often in the group with pregnancy-induced hypertension than in the control group. A possible immunological explanation for this finding is presented.
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PMID:Pregnancy-induced hypertension in twin pregnancy. 670 48

1. Circumstantial evidence suggests that immunological mechanisms might contribute to hypertension in man. If so, it would be expected that those genetic loci which influence the human immune response would also influence the risk of hypertension. 2. To test this hypothesis, the distribution of systolic blood pressure (SBP) was studied in seventy-eight families comprising 437 adults ascertained through fifty-eight probands with hypertension and twenty probands with low to normal levels of blood pressure. After allowing for the method of ascertainment of the families, and adjusting for the effects of age and sex, about 55% of the phenotypic variance of SBP could be attributed to genetic factors including 23% (42% of the additive genetic variance) attributable to the effects of immunogenetic loci (HLA and Gm). 3. This suggests that relatives with a greater number of HLA and Gm haplotypes in common had more similar SBP levels than similar relatives with fewer HLA and Gm haplotypes in common. This finding supports the hypothesis that immunological mechanisms contribute to hypertension in man.
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PMID:Genetic analysis of systolic blood pressure in Melbourne families. 675 76


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