Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020538 (hypertension)
 170,190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In the open chest dog model, the response of the left ventricle exposed to acute mechanical hypertension was evaluated while the animals were receiving various concentrations of halothane, enflurane, and isoflurane. Myocardial contractility was quantified by the end-systolic pressure-length relation (ESPL). When the mean aortic pressure was increased by 40% above the control value for a given concentration of inhalation agent, the end-diastolic volume increased and thereby maintained stroke work. However, as the end-tidal concentrations of the anesthetics increased, this compensatory mechanism became progressively more ineffective as a result of myocardial depression caused by the anesthetics. No evidence could be found of an improvement in myocardial contractility as the aortic pressure was increased. Mild depression of myocardial contractility could be demonstrated for 1.1 MAC halothane, 0.6 MAC enflurane, and 1.0 MAC isoflurane. Severe depression of contractility occurred at 2.3 MAC halothane, 1.2 MAC enflurane, and 1.5 MAC isoflurane.
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PMID:Response of the heart to acute hypertension during halothane, enflurane, and isoflurane anesthesia. 368 92

Two hundred and fifty patients aged 25 to 50 years were examined. Arterial hypertension (AH) was diagnosed in 144 persons; its mean history was 4.35 +/- 0.5 years. Insulin-independent diabetes mellitus (IIDM) and AH were observed in 71 patients; the mean history of IIDM was 3.43 +/- 0.3 years. The patients were diagnosed as having eye diseases: mild myopia and hyperopia, first- and second-degree hypertensive angioretinopathy, and diabetic angiopathy. The purpose of the study was to assess treatment compliance for eye diseases in patients with AH and IIDM in relation to the psychological status. Treatment compliance for eye diseases in patients with AH and IIDM was found to be poor. Mild depression had no significant impact on treatment compliance for eye diseases. The patients with IIDM and diagnosed eye abnormalities without signs of depression were ascertained to take drugs to stabilize visual functions more frequently than those with eye abnormalities and AH.
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PMID:[Treatment strategy for the organ of vision in patients with somatic diseases in relation to the psychological status]. 1920 2