Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0020538 (hypertension)
 170,190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In a prospective study we found a hypertonic disease in 5.26% of the pregnant women. The course of pregnancy and delivery in women with chronic hypertension (22.1%) and in women with a pregnancy hypertension (53.3%) was without complications; delivery of eutrophic children was on term. Pregnant women with pre-eclampsia (19.7%) had an early birth of dystrophic, retarded children (below the 10th percentile). The acidosis morbidity (36.4%) and the frequency of Caesarean section (79.2%) were significantly increased compared to other hypertension types. More often we found pathological para-clinical changes. The perinatal mortality occurred in women with pre-eclampsia in 10.4%. It was not increased in all other hypertension types. The emphasis in prepartal monitoring should be on women suffering from pre-eclampsia.
 ...
PMID:[Clinical significance of the classification of hypertensive diseases in pregnancy]. 193 71

Advances in prenatal care have resulted in a substantial decline in the number of serious complications associated with high blood pressure during pregnancy. Nevertheless, the hypertensive disorders remain a significant cause of maternal and fetal morbidity, and even mortality [Rochat et al. 1988]. In addition, hypertension in pregnancy is a topic that generates considerable controversy, ranging from the correct manner to measure blood pressure in gravidas, to major disputes concerning management considerations. The pervasiveness of such controversies [Cunningham and Pritchard 1984, Ferris 1984, Disdale 1988, Kaplan et al. 1988] led the United States' National Institutes of Health, through its National High Blood Pressure Education Program, to convince a working group whose "consensus" report has just been published (1990), and is recommended reading for physicians who manage gravidas. This review focuses on preeclampsia, and includes observations concerning the pathogenesis of this disorder as well as strategies to prevent its occurrence. Conflicting opinions regarding the management of preeclamptic women will also be discussed, highlighting the recommendations made by the NIH consensus group (NHBPEP 1990). Space considerations limit the references cited, and the reader is referred to a chapter [Barron 1991] and several texts [Chesley 1978, Rubin 1988] for a more complete survey of the literature.
 ...
PMID:Hypertension in pregnancy: advances and controversies. 195 42

A total of 261 of 17,000 pregnancies were complicated by pre-eclampsia/hypertension in pregnancy. Seven to twelve years later 237 were available for follow-up together with 33 women, who had a normotensive pregnancy in 1969-1973. The association between pre-eclampsia/hypertension and the premenstrual tension syndrome has been studied. Women with present hypertension complained significantly (P less than 0.05) more of premenstrual sadness than the normotensive women. However, women with previous pre-eclampsia/hypertension in pregnancy did not have more premenstrual symptoms than women in general, on the contrary, women with a history of severe pre-eclampsia had less symptoms.
 ...
PMID:Pre-eclampsia, hypertension and the premenstrual tension syndrome. 197 97

There is controversy over the effect of hypertension in pregnancy on the incidence of neonatal respiratory distress syndrome. We investigated the association between maternal hypertension and the incidence of respiratory distress syndrome in 268 very low birthweight babies of less than 34 weeks' gestation. A lower incidence of respiratory distress syndrome was associated with growth retardation and membrane rupture greater than 24 hours. Maternal hypertension was associated with an increased incidence of respiratory distress syndrome. We used the multiple logistic regression model to control for confounding variables, as the maternal and neonatal factors associated with respiratory distress syndrome were not evenly distributed between the two groups. After adjustment for birth weight, gestational age, growth retardation, and membrane rupture greater than 24 hours, the risk of developing respiratory distress syndrome was significantly greater in babies of hypertensive mothers. Significance was lost when labour before delivery and mode of delivery were taken into account. The increased incidence of respiratory distress syndrome in babies of hypertensive mothers may be due to the absence of labour before delivery because of the greater likelihood of caesarean section.
 ...
PMID:Increased incidence of respiratory distress syndrome in babies of hypertensive mothers. 199 93

Hypertensive diseases of pregnancy are commonly manifested in renal and ocular changes. Proper evaluation of findings provided by urine analysis, renal biopsy and examination of the optic fundi, visual acuity, and visual fields may help in assessing the severity of the disease and the need for obstetric intervention. Furthermore, renal and ocular changes are important guides in the differential diagnosis of hypertensive disorders of pregnancy. Renal and ocular lesions have also been found to have important prognostic implications. Review of the current knowledge on renal and ocular pathophysiologic changes induced by hypertension in pregnancy, may in addition shade light on the obscure etiology of this common entity.
 ...
PMID:Renal and ocular manifestations of hypertensive diseases of pregnancy. 199 26

The purpose of the study was to determine if reduction of pregnancy hypertension to normal prevented the clinical maternal manifestations of pre-eclampsia. Thirty-six women with hypertension, but without proteinuria, were allotted at random to a test group of 17 who received intensive treatment, and a control group of 19 who were managed according to routine methods by hospital staff unconnected with the study. The development of proteinuria was chosen as an indicator of pre-eclampsia. Proteinuria developed significantly more often in the control group (in six of the 19 women) than in the test group (in one of the 17 women).
 ...
PMID:The prevention of the maternal manifestations of pre-eclampsia by intensive antihypertensive treatment. 202 61

Treatment of severe hypertension in pregnancy, particularly in preeclampsia and eclampsia, is a great challenge to the obstetrician and requires prompt and expert management. Application of antihypertensive agents is limited during pregnancy because of possible side effects, particularly impairment of the fetal state. The following survey present a detailed discussion on the substances suitable for treating hypertensive emergencies in pregnancy and their side effects. Despite restricted therapeutic possibilities, safe and successful treatment of severe hypertension during pregnancy can best be performed with dihydralazine and diazoxide, which achieve their effect by reducing the peripheral vascular resistance. If the blood pressure cannot be adequately reduced with these substances, treatment can be continued with sodium nitroprusside. A critical discussion is presented in this connection on drugs such as clonidine and reserpine, which reduce pressure largely by central mechanisms and should no longer be applied in pregnant patients because of serious disadvantages. Consideration is also given to the special clinical problems associated with pheochromocytomas, and a concluding discussion deals with the perspectives of antihypertensive therapy in pregnancy.
 ...
PMID:[Treatment of severe hypertension in pregnancy]. 205 78

Of the immunological alterations in pregnancy hypertension were studied peripheral blood lymphocyte subpopulation in normal and hypertensive pregnancies by means of monoclonal antibodies. In pregnant women with hypertension an increase was found in NK activity. It was also shown that an increase in circulating T cells expressing Tac antigen occurred in women with pregnancy hypertension. These preliminary data on Tac antigen suggest that there is an activation of Leu 3 cells; which may introduce the concept of Leu 3 activity like NK activity. Further studies on this subject could explain that the concept of Leu 3 activity is correct.
 ...
PMID:Natural killer cells and Tac antigen in the hypertension of pregnancy. 214 25

Doppler studies of the umbilical and uteroplacental bed arterial flow velocity waveforms were performed in a series of women suffering from severe proteinuric pregnancy hypertension. Ninety-five women were studied and the mean interval between the last study and delivery was 1.4 days. An abnormally elevated umbilical artery systolic:diastolic (AB) ratio was present in 61 (64%) of the women. All 10 perinatal deaths were associated with pregnancies with an abnormal umbilical artery AB ratio. An elevated umbilical artery AB ratio was significantly associated with small-for-gestation and neonatal morbidity. Infants associated with extremely high umbilical artery AB ratios (greater than or equal to 99th centile) spent twice as long in the neonatal nursery as those with a lower value. There was no relation between the duration of hypertension and the umbilical study result. The uteroplacental bed artery flow velocity waveform did not correlate with fetal or neonatal mortality or morbidity. Patients with abnormal uteroplacental AB ratios also had abnormal umbilical artery AB ratios. We conclude that an abnormal fetal umbilical artery Doppler flow velocity waveform correlates with adverse fetal outcome in severe proteinuric pregnancy hypertension and suggest that the associated placental lesion may precede the maternal hypertension.
 ...
PMID:Doppler umbilical and uterine flow waveforms in severe pregnancy hypertension. 218 Apr 75

We analysed 216 patients with gestational diabetes over a 3 year period. These patients were managed by a diabetic team under a standardised protocol. Forty percent of these patients required insulin therapy. The incidence of pregnancy hypertension was 14.4%, macrosomia 8.8% and major congenital malformation 3.7%. The Caesarean Section rate was 34% and the overall Perinatal Mortality Rate was 1.9%. However, neonatal morbidity rate remained high--44% of infants have had one neonatal complication and 17.6% had 2 or more complications. Pregnancy outcome was further analysed among patients with different degrees of glucose intolerance at diagnosis. We noted that both macrosomic rate, neonatal morbidity rate, as well as proportion of patients requiring insulin were higher in the group with a higher degree of glucose intolerance. There was, however, no difference in incidence of hypertension or hydramnios in the different subgroups.
 ...
PMID:Management and outcome of gestational diabetes in Alexandra Hospital, Singapore. 222 3


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>