Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020538 (hypertension)
 170,190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Insulin-secreting pancreatic tumors and insulin-like growth hormone-secreting non-islet cell tumors can cause hypoglycemia. However, insulin-releasing paraganglioma or pheochromocytoma has almost never been reported. A 67-year-old female patient was admitted to our hospital because of headache, palpitation, perspiration, faintness, frequent sense of hunger and absent-mindedness. These intermittent symptoms had begun approximately a year before admission. On physical examination, she had high blood pressure of 150/90 mm Hg. Hormonal studies demonstrated increased urinary norepinephrine levels, and hyperinsulinemic hypoglycemia was confirmed while the patient was symptomatic. Abdominal MRI revealed a retroperitoneal mass measuring 4.5 cm in the pancreatic region. She was treated with an alpha-blocking agent to control blood pressure preceding the removal of the mass. Histopathological diagnosis was paraganglioma, and immunohistochemically insulin staining in the neoplastic cells was demonstrated. Her blood pressure normalized and hypoglycemia relieved after the operation. The patient did not have recurrence of hypoglycemia after a year of follow-up. Paraganglioma is a rare tumor of the neural crest, and co-secretion of insulin and catecholamines has been reported only by a single case report in the literature. The present patient is another case with this co-secretion.
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PMID:Hypoglycemia due to ectopic release of insulin from a paraganglioma. 1728 22

The authors analyzed 307 questionnaires of patients with essential hypertension (EH) in order to study the influence of social and economic factors on compliance to outpatient therapy. The analysis shows that about 55% of patients take antihypertensive medication on a regular basis. The most frequent reasons for non-compliance to treatment are financial problems, personal features such as forgetfulness and absent-mindedness, lack of motivation towards treatment, the necessity to take a large number of drugs, not knowing about the necessity to take medicines on a regular basis, fear of complications of the therapy etc. There is a strong positive correlation between patients" compliance, on the one hand, and the length of the disease and the level of education, on the other. The was a negative correlation between compliance, on the one hand, and the number of medicines taken, the financial income, the cost of antihypertensive medication, and the number of visits to the doctor during the year. Measures to increase the compliance of patients with EH to treatment include improvement of education of doctors on pharmacoeconomic issues, a wider use of educational actions for patients, improvement of the quality of outpatient observation and the work of schools for patients with arterial hypertension, as well as introduction of preferential provision with pharmaceuticals for all patients with arterial hypertension.
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PMID:[The influence of socio-economic factors on the compliance of patients with treatment of hypertonic disease]. 1752 10