Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020538 (hypertension)
 170,190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Renal prognosis is not clear in adults with Henoch-Schoenlein nephritis (HSN). Renal biopsy material from seventeen adult patients with HSN was studied by light-, electron-, and immunofluorescent microscopy, and a clinicopathologic correlation was made. The outstanding glomerular lesion was a mesangial IgA deposition, apart from the proliferative glomerulonephritis associated with segmental lesions or crescents. At the time of biopsy five patients (29%) presented with renal insufficiency complicated by nephrotic syndrome and/or hypertension. After a mean follow-up period of 3.2 years, ten patients showed complete recovery, two had minor urinary abnormalities, and five exhibited moderate proteinuria with or without hematuria. No patients had died nor developed chronic renal failure. Our data indicate that the outcome of HSN in adults is favorable similar to that in children. No initial clinical nor pathological features could be associated with a poor prognosis in this study. Further follow-up is needed in view of the unpredictable nature of this disease.
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PMID:Henoch-Schoenlein nephritis in adults: a clinical and morphological study. 376 27

Fourty-four children with Henoch-Schoenlein nephritis were studied at the onset of the nephropathy and during a follow-up from 6 to 110 months. The extra-renal manifestations were purpura (100%), abdominal pain (63.5)% or melena (27%), arthlagias (61.5%), neurological symptoms with convulsions (4.5%) and retinal involvement (4.5%). The clinical presentation of the nephropathy consisted in haematuria and proteinuria (41%), isolated haematuria (30%), acute renal failure (ARF) (23%), nephrotic syndrome (4%) or isolated proteinuria (2%). Hypertension was present in 17 patients. Renal biopsy was performed in 18 patients and the glomerular changes were graded according to the classification of ISKDC; the renal histopathology ranged from minimal lesions to severe crescentic glomerulonephritis and was found to correlate with clinical state. Twenty-four patients, who showed severe clinical presentation and/or diffuse mesangial proliferation with high proportion of crescents, received a corticosteroid therapy. Most of our patients followed a relatively benign course: all but one of patients with ARF have normal renal function at the end of follow-up and no patients with less severe renal presentation got a bad outcome. Only 2 patients showed relapse of nephropathy and purpura at the 6th and 8th year of follow-up, respectively. After 24 months of follow-up the clinical outcome of a group of 19 patients receiving corticosteroid therapy was not very different from that of 11 untreated patients.
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PMID:[Clinical aspects of the nephropathy in Schoenlein-Henoch syndrome]. 378 92

Eighty-three children with Henoch-Schoenlein nephritis were studied to establish the prognostic significance of the glomerular changes. After a mean follow-up period of 6 years, 44 patients had no demonstrable abnormality, 21 had minor urinary abnormalities, 8 had heavy proteinuria and/or hypertension, and 10 had either died or developed chronic renal failure. Patients presenting with hypertension and/or acute renal insufficiency were more likely to develop chronic renal failure than those with milder presentations. A poor outcome was found to correlate with (1) crescents and segmental lesions affecting a high proportion of glomeruli, (2) the presence of subepithelial electron-dense deposits and (3) the finding of extracellular "lead shot" microparticles. While the clinical presentation is not a good means of predicting the outcome, an acute nephritic onset nevertheless appears to be the best available indication for renal biopsy, which should include both light and electron microscopy in order to increase the precision of prognostication.
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PMID:Prognostic significance of the glomerular changes in Henoch-Schoenlein nephritis. 703 May 44

The study includes 100 renal biopsies from an equal number of patients referred to us with nephrotic syndrome (NS). Their ages ranged from one month to 13 years (medial five years) and included 59 males and 41 females. Indications for kidney biopsy were steroid resistance in 41 patients, steroid dependence with frequent relapses on maintenance steroid therapy in 38, NS associated with gross hematuria, hypertension, azotemia, and/or systemic manifestations in eight and age of less than one year at the onset of the disease in 13 patients. In 90 patients, NS was idiopathic in origin and in eight, it was secondary to IgA nephropathy, hemolytic-uremic syndrome, post streptococcal glomerulonephritis, antiglomerular basement membrane antibodies, Henoch-Schonlein nephritis and systemic lupus erythematosus. Two patients had hepatitis B infection and its relationship with NS could not be elucidated. Primary NS is the predominan type of NS in the local pediatric population. The disease in more common in the first year of life. A relatively high incidence of diffuse mesangioproliferative glomerulonephritis (MesPGN) and rarity of infection-related NS are noted.
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PMID:Spectrum of renal pathology in 100 selected children with nephrotic syndrome. 1759 Jul 21