Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020538 (hypertension)
 170,190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The components of the vascular-thrombocyte hemostasis were studied in two models of arterial hypertension: the genetically determined spontaneous (SAH) hypertension and the acute renovascular one (RAH). The reactivity of thrombocytes to the aggregation inductors was increased in hypertensive rats. Disaggregation was considerably accelerated in RAH which led to a shortening of the aggregation response. The contents of serotonin free adenine nucleotides and glycogen were decreased in the thrombocyte of hypertensive rats, the serotonin exchange was altered and the aorta antiaggregation activity was enhanced. The model of laser-induced thrombosis revealed an enhancement of thrombogenesis and a reduction of thromboresistance of the vessels in SAH. The prevalence of the thrombogenesis in vessels seems to be a potentiating factor for thrombosis in hypertension.
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PMID:[Vasculo-thrombocyte hemostasis in arterial hypertension]. 324 85

The present review synthesizes "the state of the art" concerning resistant (refractory) arterial hypertension (RAH). Definition, epidemiology, frequent risk factors, clinical conditions and causes of therapeutic resistance of RAH are revisited. Pathogenic hypothesis and related therapeutic approaches are explored. The paper lists current and new pharmacological therapies of RAH and introduces the latest interventional approach (the Rheos BHT system) to this form of arterial hypertension.
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PMID:[Refractory arterial hypertension]. 1929 95