Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020538 (hypertension)
 170,190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Seventeen patients with recurrent intracerebral gliomas were given alcohol injection percutaneously guided by ultrasonography. These patients suffered from supratentorial tumors and were operated on previously. The fluid of cystic lesions of 13 patients was aspirated and absolate alcohol was injected for 5-8 times. The cystic cavities soon disappeared followed by symptoms of intracerebral hypertension. Biopsies from different parts of tumor cavity showed that tumor cells were degenerated and necrotized. There was no curable effect on larger solid neoplasm and deep sited solid tumor. We conclude that percutaneous alcohol injection is effective in the treatment of recurrent gliomas.
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PMID:[Alcohol injections for the treatment of recurrent intracerebral gliomas]. 181 65

By using transparent chambers in rats, it proved possible to observe directly the normal vascular pattern and early neovascular response to solid tumor growth at high magnification. Morphologic studies of the vascularization patterns were performed daily by construction of photomontages from color instant film taken with a Polaroid camera. Noteworthy results obtained in this study were: In the normal subcutaneous tissue within the chamber, the main vascular pattern was similar to that described by Nicoll and Webb, showing the so-called "arcuate arteriolar pattern". The thoroughfare channel reported by Chambers and Zweifach was also observed. The establishment of new functional capillaries was observed within 2 weeks following the implantation of AH109A and AH272 tumors. The sprouts of newly formed vessels were seen originating at the arterial ends of the host capillaries, where the blood velocity was relatively high. The formation of intricate networks in the tumor occurred easily in a haphazard way; the three modes of network formation observed were sprouting, cross-connection and splitting. Progressive dilatation and tortuosity were observed in the preexisting vessels, especially capillaries and venules, in the neighborhood of the tumor implant. The arterioles, however, remained little altered and in a location almost identical to that at the time of tumor implantation. The vascular systems in the tumors were proved to parallel those in the normal organs from which they originated, from the microfocus stage to the large tumor stage. An understanding of the differences in the vascular architecture between normal and tumor tissue seems to be essential in order to elucidate the mechanism of enhancement of therapeutic effect by angiotensin II induced hypertension chemotherapy.
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PMID:[Intravital observations on the development of the tumor vascular system in rats]. 243 77

A boy of two years has an hematuria which was first related with an hypertensive acute glomerulonephritis. However because of recurrency of the hematuria radiological investigations were performed and a solid tumor of the right kidney was discovered. The arterial hypertension regressed after the right nephrectomy. Pathology demonstrated a tumor of Grawitz which is rare in children and which is seldom associated with an arterial hypertension. We found only five similar cases in the literature. Arterial hypertension can be related either with a compression of the renal artery of with an inadequate secretion of renin by the tumor.
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PMID:[Grawitz's tumor with arterial hypertension in children. Apropos of a case]. 380 80

Two rare cases of pheochromocytoma were reported. Case 1 was 39-year-old housewife who was referred for history of high fever with left hypochondralgia twice in the previous 15 months before coming to our department. The patient had neither elevation of blood pressure nor that of central and peripheral venous catecholamine concentration. A left suprarenal mass was found in CT, which was suggested to be a cyst due to the numerical value between 23-24. Further ultrasonographic study indicated a solid tumor. Left adrenalectomy was done. Histologically, some of the viable atypical adrenal cells were found in the capsulating tissue contained the necrotic material which was almost occupying the entire mass. Case 2 was a 64-year-old female with hypertension who was admitted for further examination. On the hospital course, the blood pressure returned to normal without medication. Circulating blood volume was extremely reduced (below 1/2 of normal), the replacement of which raised the blood pressure to cause hypertension. An angiographic study indicated only a right adrenal mass, whereas left adrenal venous catecholamine concentration was significantly higher than that of the right side. After confirming right adrenal with no other disorders by CT scan, right adrenalectomy was carried out. Intraoperative correction of hypertension has been sustained and cardiovascular symptoms have disappeared.
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PMID:[Rare cases of pheochromocytoma. A report of two cases]. 408 4

Although cancer has an annual incidence of only about 150 new cases per 1 million U.S. children, it is the second leading cause of childhood deaths. Early detection and prompt therapy have the potential to reduce mortality. Leukemias, lymphomas and central nervous system tumors account for more than one half of new cancer cases in children. Early in the disease, leukemia may cause nonspecific symptoms similar to those of a viral infection. Leukemia should be suspected if persistent vague symptoms are accompanied by evidence of abnormal bleeding, bone pain, lymphadenopathy or hepatosplenomegaly. The presenting symptoms of a brain tumor may include elevated intracranial pressure, nerve abnormalities and seizures. A spinal tumor often presents with signs and symptoms of spinal cord compression. In children, lymphoma may present as one or more painless masses, often in the neck, accompanied by signs and symptoms resulting from local compression, as well as signs and symptoms of systemic disturbances, such as fever and weight loss. A neuroblastoma may arise from sympathetic nervous tissue anywhere in the body, but this tumor most often develops in the abdomen. The presentation depends on the local effects of the solid tumor and any metastases. An abdominal mass in a child may also be due to Wilms' tumor. This neoplasm may present with renal signs and symptoms, such as hypertension, hematuria and abdominal pain. A tumor of the musculoskeletal system is often first detected when trauma appears to cause pain and dysfunction out of proportion to the injury. Primary care physicians should be alert for possible presenting signs and symptoms of childhood malignancy, particularly in patients with Down syndrome or other congenital and familial conditions associated with an increased risk of cancer.
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PMID:Recognition of common childhood malignancies. 1077 55

Neuroblastoma is a common solid tumor of childhood that can involve the abdomen, thorax, pelvis, or the head and neck. The clinical manifestations are dependent on the widespread distribution of neural crest tissue and the length of the sympathetic chain involvement. Abdominal pain and hypertension may occur as a result of renal vasculature compression; respiratory distress may be evident in thoracic tumors; and Homer's syndrome or heterochromia of the iris may manifest from neuroblastoma of the head and neck. In addition, symptoms of cord compression and back pain may result from spinal cord compromise due to epidural invasion. Metastatic involvement of the liver, skin, periorbital regions, or bone may cause hepatomegaly, skin nodules, proptosis, or bone marrow failure, respectively. Clinical findings along with tumor metastasis may be studied by various imaging modalities to assess the nature and extent of the tumor. Diagnostic tests include plain radiography, ultrasonography, CT scanning, and MR imaging. Bone marrow studies, bone scans, and scintigraphy with 131I-metaiodobenzylmandelic may be utilized for metastatic evaluation. By using these imaging studies to detect the nature and behavior of neuroblastoma, early intervention may indeed improve patient survival.
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PMID:Imaging neuroblastoma in children. 1262 83

A patient with paraganglioma of the urinary bladder is reported. A 65-year-old woman was referred to our hospital with the chief complaint of postvoiding headache, palpitation, and cold sweat. She had has no episodes of hematuria. On laboratory data, mild elevation was found in plasma neuron specific enolase (NSE), urinary noradrenaline and urinary metanephrine. The patient showed hypertension after urination with the elevation of plasma noradrenaline. 131I-MIBG scintigraphy showed abnormal accumulation in the bladder, and no abnormal accumulation in the other lesion. Pelvic magnetic resonance imaging (MRI) revealed a solid tumor of the urinary bladder, measuring 2 cm in diameter. Paraganglioma of the urinary bladder was diagnosed and the tumor was extirpated. The tumor measured 2 x 2 x 1.5 cm, and histopathologically diagnosed as paraganglioma. After extirpation, the patient became free of the postvoiding symptoms, and showed normal catecholamine levels. She has been followed up for 4 months after operation without any evidence of recurrence.
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PMID:[Paraganglioma of the urinary bladder: a case report]. 1647 92

A 61-year old female presented with paroxysmal hypertension and a 4.5cm left adrenal mass on CT scan. Repeated measurements of 24-hour urinary fractionated metanephrines, total catecholamines and vanillylmandelic acid (VMA) were within normal range. A further scintigraphic study with (131)I -metaiodobenzylguanidine ((131)I-MIBG) revealed selective concentration of the radiotracer, corresponding to the CT mass. After adequate preoperative treatment, successful surgical excision of the tumor was performed and the pathological examination confirmed the diagnosis of a cystic pheochromocytoma with a 2cm solid tumor. On reevaluation three months later using (131)I-MIBG, no evidence of remaining or recurrent disease was found. The patient, off any antihypertensive medication, reported mild recurrent hypertension and panic attacks that were adequately controlled with antidepressants. This is a rare case of a symptomatic pheochromocytoma without elevated urine catecholamines and metanephrines. According to the literature, plasma free metanephrines would be the ideal test for biochemical detection of the tumor. However, in the event that they are not available and there is a high clinical suspicion for the presence of pheochromocytoma, as in our patient, we suggest performance of a functional nuclear medicine study, such as (131)I-MIBG, to confirm the clinical diagnosis.
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PMID:Symptomatic pheochromocytoma with normal urinary catecholamine metabolites. 1698 88

A 72-year-old man with diabetes mellitus and hypertension was admitted for further examination and therapy of diabetes. In order to evaluate his pancreas, abdominal computed tomography (CT) was performed, showing a space-occupying lesion (SOL) in the pancreatic uncus. He did not show any symptoms related to the pancreas or gastro intestinal tract. Three-dimensional CT (3D-CT) indicated that the SOL was not a solid tumor but a vessel fistula, fed by the superior mesenteric artery and the gastro duodenal artery, drained by the superior mesenteric vein. Abdominal angiography also showed its peculiar vessel structure, confirming arterio-venous (A-V) malformation in the pancreas. Pancreatic A-V malformation is a rare condition but should not be forgotten in the differential diagnosis of pancreatic SOL. Our case showed the advantages of 3D-CT with its low invasiveness and convenience for the diagnosis of A-V malformation in the pancreas.
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PMID:[Case report of asymptomatic arteriovenous malformation (AVM) of the pancreas; diagnostic advantage of three-dimensional computed tomography]. 1723 9

The purpose of the research was to demonstrate that comorbid health conditions disproportionately affect elderly cancer patients. Descriptive analyses and stacked area charts were used to examine the prevalence and severity of comorbid ailments by age of 27,506 newly diagnosed patients treated at one of eight cancer centers between 1998 and 2003. Hypertension was the most common ailment in all patients, diabetes was the second most prevalent ailment in middle-aged patients, and previous solid tumor(s) were the second most prevalent ailment in patients aged 74 and older. Although the prevalence and severity of comorbid ailments including dementia and congestive heart failure increased with age, some comorbidities such as HIV/AIDS and obesity decreased. Advances in cancer interventions have increased survivorship, but the impact of the changing prevalence and severity of comorbidities at different ages has implications for targeted research into targeted clinical and psychosocial interventions.
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PMID:The changing prevalence of comorbidity across the age spectrum. 1837 41


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