Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020538 (hypertension)
 170,190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Previous studies suggest abnormalities in PO4 and perhaps vitamin D metabolism in the spontaneously hypertensive rat (SHR) compared with normotensive Wistar-Kyoto (WKY) control rats. The mechanism for the hypophosphaturia obscure, but intestinal malabsorption of P and/or the possibility of linkage to renal Na avidity has not been evaluated. Furthermore, if sustained, the potential effects of the hypophosphaturia on P balance are not known. The present investigation examined these issues. We found that the reduced P excretion occurs as early as age 22 days, the second day after weaning in the SHR, well before the onset of detectable hypertension. This phenomenon is dissociable from renal Na avidity, and sustained through the 12th week of age, the last week of our studies. Since P absorption is normal, external P balance is increased relative to the WKY control rats. The greater cumulative P retention from infancy to adulthood may explain the age-dependent fall in serum 1,25 dihydroxyvitamin D3 [1,25(OH)2D3] reported in the SHR by some investigators.
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PMID:Nature and metabolic consequence of hypophosphaturia in spontaneously hypertensive rats. 347 94

Previous studies indicated a salutary effect of a high-Ca diet on high blood pressure (BP). The mechanism, however, is obscure. With balance and clearance techniques, the role of parathyroid hormone (PTH), volume contraction, hypercalcemia, and PO4 deficiency was evaluated in female spontaneous hypertensive rats (SHR). The antihypertensive effects of a high (4.3%) Ca diet in intact animals (groups I and II) could be reproduced in both 9- and 22-wk-old chronic stable parathyroidectomized (PTX) rats (groups III and IV), when compared with a low (0.22%) or normal (1.2%) CA diet. In both short (7 days) and long (12 wk) term exposure to the high-Ca diet, evidence for volume contraction could not be documented despite hypercalcemia sustained through the 12th wk (10.8 vs. 9.7 mg/100 ml, group I control, P less than 0.02). When produced by ip injections, chronic hypercalcemia of similar magnitudes as oral Ca supplements failed to reduce BP in either intact (group VI) or PTX (group IV) rats. Rats in group IV fed the high-Ca diet displayed marked hypophosphatemia (3.2 vs. 6.9 mg/100 ml), hypophosphaturia (0.15 vs. 15 mg/day), hypermagnesiuria (11 vs. 7.7 mg/day), and drastically reduced net intestinal PO4 absorption (13.3 +/- 7.5 vs. 66.8 +/- 7.5 mg/day) compared with rats fed 1.2% Ca diet. To test the PO4-deficiency hypothesis, additional SHR (group V) were fed either 1.2% Ca diet and injected ip with NaCl or fed 4.3% Ca diet, with half of these animals injected with neutral NaPO4 and half with NaCl.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Evidence for the role of PO4 deficiency in antihypertensive action of a high-Ca diet. 670 70