Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0020538 (hypertension)
 170,190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Polyarteritis was diagnosed in three girls, 9 to 10 years old, by kidney and skin biopsies. They were treated with a combination of prednisone (1.5 to 2 mg/kg) and cyclophosphamide (2 mg/kg) for up to 12 months. The illness was severe in all three, complicated by hypertension, seizures, pulmonary infiltrates, renal failure, or hallucinations. All three patients are alive and well with no or minimal residual symptoms two to three years after therapy was discontinued. The treatment with corticosteroids or with a combination of steroids and immunosuppressive drugs seems to improve the prognosis of polyarteritis considerably.
 ...
PMID:Polyarteritis in children. 0 83

Polyarteritis in the older child is thought to be a rare disease. This study describes 11 children, 3 to 12 years of age, with polyarteritis seen over a five-year period. Fever, abdominal pain, hypertension, and leukocytosis were found in almost all. Renal disease occurred in eight. Examination of muscle, gut, or kidney tissue was an effective means of diagnosis. The pathological changes were the same as those seen in adults. There seemed to be an association between polyarteritis and group A streptococcal infection. Ten patients had a salutary response to high-dose prednisone administration.
 ...
PMID:Polyarteritis nodosa in older children. 1 1

We investigated pauci-immune crescentic glomerulonephritis (PICGN) in Chinese patients, During 11 years (1985-1996), 5,800 patients underwent renal biopsy in Nanjing Jinling Hospital. Eighteen patients were diagnosed as having PICGN. They were 11 women and 7 men with median age of 29 (range 10-71 years). Polyarteritis (33.3%) and polyarteritis nodosa (11.1%) were the secondary diseases. The incidence of PICGN was 0.31% in renal biopsies and 23.10% in crescentic glomerulonephritis. Clinically, most patients (83.3%) showed rapidly progressive nephritis with enlarged kidneys. Gross hemoturia was noted in 61.1% patients, hypertension 44.4%, nephrotic syndrome 44.4%, and oligria 33.3%. However, systemic symptoms were rare except anemia. Pathologically, we observed necrosis of glomerular capillaries (61.1%), infiltration of monocytes and neutrophil cells in glomeruli (44.4%), and vasculitis in interstitium (55.5%), in addition to glomerulosclerosis (44.4%), severe tubular atrophy (83.3%) and interstitial fibrosis (72.2%). Antineutrophil cytoplasmic antibodies (ANCA) was positive in 41.7%. All patients except one received intensively immunosuppressive therapy. 12 patients were subjected to long-term follow up (median 25.9, range 8-72 months). Only three patients were dialysis-dependent, while none died.
 ...
PMID:[Clinical and pathological characteristics in Chinese patients with pauci-immune crescentic glomerulonephritis]. 1045 45