Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020538 (hypertension)
 170,190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Studies were performed to assess clinical applicability and usefullness of several non-invasive indices of myocardial contractility, especially, ET/PEP, Pd/ICT and (Pd/ICT)(AO/EO). In dogs preload, afterload or myocardial contractility was altered by durgs. The ET/PEP was influenced by preload as well afterload and PdICT by afterload, respectively. A correction of Pd/ICT with preload, (Pd/ICT)/(AO/EO)showed a satisfactory correlation to Vmas even when the preload and/or afterload were altered. In clinical cases, ET/PEP, Pd/ICT and (Pd/ICT)/(AO/EO) all changed following administration of positive inotropic substances. Moreover, in azotemic cases with primary change in preload the gradient of the Frank-Sterling's curve increased progressively and the entire curve was located upwards with increase of (Pd/ICT)/(AO/EO) value. In case of high-resistance type hypertension, nevertheless, (Pd/ICT)/(AO/EO) showed a tendency to change in association with alteration of its constituent factor Pd. Since there exists no absolutely perfect non-invasive index of myocardial contractility available for clinical application as yet, it would be appropriate to make overall evaluation of myocardial contractility by combined use of several indices, with underlying pathological conditions and characteristics of individual parameters taken into consideration.
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PMID:Clinical evaluation of myocardial contractility and its problems. 87 31

The systolic time intervals (LVET, PEP, and ratio LVET/PEP) were determined in 53 patients presenting with signs or symptoms of thyroid dysfunction. Patients with clinical evidence of congestive heart failure, with arterial hypertension or old myocardial infarction, and patients receiving cardioactive drugs, were excluded from the study. Thyroid function was evaluated by means of T3-RIA, serum thyroxin and TRH stimulation test.
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PMID:[The systolic time intervals in functional disorders of the thyroid: a simple and fast screening test]. 101 11

An indirect and direct estimate of the left ventricular performances were compared in 45 patients with hypertension, arteriosclerotic heart disease and miscellaneous diseases. In results, externally measured LVET, ET/PEP, PEP and a wave ratio correlated well with internally measured myocardial function. Therefore it was concluded that this convenient and atraumatic method was useful as a valid and sensitive measure of myocardial performance.
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PMID:[Correlation of external cardiac indices with internal parameter of left ventricular function in hypertension and ischemic heart disease (author's transl)]. 115 99

In evaluation of cardiac function by the non-invasive method, the possibility of separation of cardiac muscle performance from cardiac pump performance was studied. Among the non-invasive values, SV/ET, SV/(AO/EO), Pd/ICT, Pd/PEP, 1/ICT2, ET/PEP, and ET/ICT were considered as parameters for myocardial contractility. This research especially focused on Pd/ICT and ET/PEP. In auricular fibrillation it was possible to draw Starling-like curves and 3 dimensional coordinates to estimate a Vmax-like value. However this method could not be used in sinus rhythm. Whereas, in hypertension with abnormal afterload and uremia with abnormal preload, myocardial contractility was expressed by Pd/ICT under the influence of almost pure preload and ET/PEP under the influence of both preload and afterload. Therefore Pd/ICT was corrected with preload (AO/EO) and (Pd/ICT)/(AO/EO) may be used as the index for myocardial contractility.
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PMID:Evaluation of myocardial contractility by the non-invasive method. 115 34

In order to study the hemodynamic effects of the antihypertensive drugs in patients with essential hypertension, systolic time intervals from ECG data were extrapolated. The study was performed in 36 healthy individuals and 38 patients with essential hypertension without a drug therapy and/or in the wash out period more than three weeks and after a treatment. The stroke volume (SV) was determined as a product of the ejection time (ET), the pulse pressure (PP) and the flow coefficient (Kf). The Kf was extrapolated from Doppler-cardiographic parameters and it significantly correlated with the normal diastolic blood pressure (TA(d)) if the QT is not prolonged and the electrical systole/mechanical systole ratio (QS2/MS) not disturbed: Kf = 9.356 e-0.008 TA(d); r = -0.9. In arterial hypertension the correlation was also curvilinear: kf = 3.962 e-0.001 TA(d); r = -0.99. The arteriolar stiffness was defined as the PP/SV ratio. The cardiac output (CO) and systemic vascular resistance (SVR) were determined according to conventional formulas by known clinical and extrapolated ECG data. The cardiac contractile or muscle performance was defined as corrected changes of the ejection function for the given afterload according to the formula: I (-0.004 TA(d) + PEP/ET) -0.014 x 100; the normal 95% confidence limits for the laboratory used are -6.6% to +6%. Systolic time intervals were extrapolated from ECG data in the consecutive manner: QS2 = kQS2 x QT, ET = kET x JT, and MS = kMS x ET. The correlation of kQS2 with QT is curvilinear: kQS2 = 2.760 e-2.732 QT.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Electrocardiographic and clinical anticipation of the left ventricular systolic function, systemic vascular resistance, and myocardial hypertrophy--normal values and validation of method in patients with arterial hypertension. 138 Mar 56

The aim of the study was to assess effectiveness of surgery in management of coronary artery disease (CAD) during long-term follow-up in bearings of physical efficiency and work resumption. 21 males observed during 3-7 years after coronary artery by-pass grafting (CABG) underwent the study. Patients age ranged from 37 to 60 years (mean 51.7) at the beginning of the follow-up. 10 patients had hypertension and 12 suffered from myocardial infarction before CABG. Number of by-pass grafts ranged from 2 to 4. Postsurgical rehabilitation was performed in the cardiological health resort hospital. Assessment was based on anamnesis and physical, ECG, noninvasive as well as ECG bicycle exercise stress examinations. Long-term follow-up proved significant postoperative increase of exercise tolerance expressed by prolongation of ECG exercise test duration as well as augmentation of maximal load and performed work. Left ventricular contractility improvement measured by LVET/PEP and LVETI parameters was also stated. The best results were observed up to 6 years after surgery in patients with grafted left anterior descending artery. Preoperative myocardial infarction did not effect on longterm results of surgery. 75% of patients resumed a work after myocardial revascularization.
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PMID:[Evaluation of late surgical results in coronary disease supported by exercise stress test, noninvasive examination and work resumption]. 208 72

Left ventricular functions were assessed in 96 patients (26 men, 70 women aged over 65 years; mean age 74.6 +/- 6.3 years) with various cardiovascular diseases (arterial hypertension, coronary heart disease, cardiomyopathy, various cardiac defects) by comparing various left-ventricular time intervals obtained from resting ECGs, apex cardiograms, carotid-pulse curves and phonocardiograms with left-ventricular ejection fractions by echocardiography. The correlations were strongest with the Weissler index (ratio of pre-ejection and left-ventricular ejection times), PEP/LVET (r = -0.76; P less than 0.001), with PEP itself (r = -0.65; P less than 0.001), as well as with rate-corrected PEP (r = -0.71; P less than 0.001). The plain chest X-ray did not make it possible to assess quantitatively patients with diminished cardiac pump function, despite radiological signs of congestion.
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PMID:[Noninvasive studies of the left ventricular systolic function in patients over 65 years old]. 235 61

The effects of single doses of 10, 20, and 40 mg of bisoprolol on left ventricular performance were assessed by left ventricular systolic time interval measurements, echocardiographic measurements, and exercise stress tests in patients with mild to moderate arterial hypertension. Bisoprolol caused a significant, dose-dependent fall in systolic and diastolic blood pressure and heart rate, at rest and under exercise stress test. Left ventricular systolic time intervals were prolonged at the higher doses, but pre-ejection period/left ventricular ejection time (PEP/LVET) ratio, as an indicator for left ventricular performance, remained unchanged. Left ventricular echocardiographic dimensions increased significantly, but shortening fraction was not altered. We conclude that 10-40 mg bisoprolol, apart from the blockade of beta 1-adrenoceptors, does not affect left ventricular cardiac function.
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PMID:Noninvasive assessment of left ventricular performance after administration of bisoprolol. 243 6

A group of 125 patients (of the total of 400 patients) had ischaemic ST-segment depression (greater than or equal to 1 mm) on exercise electrocardiogram. Of 125 patients with ischaemic response on exercise electrocardiogram 83 (66.4%) patients had both ST-segment depression and anginal pain, and 43 (33.6%) patients were without ischaemic symptoms during exercise testing. There was no difference with regard to sex and age between patients with and without anginal pain. There was no difference in frequency of arterial hypertension, but diabetes mellitus was more frequent in patients with painless ST-segment depression than in patients with painful ST-segment depression. Left ventricular function was more deteriorated in patients with painless ST-segment depression (PEP/LVET = 0.390 +/- 0.028) than in symptomatic patients (PEP/LVET = 0.366 +/- 0.042; P/0.001). There was no difference in heart rate on peak exercise and in magnitude of ST-segment depression in patients with and without anginal pain.
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PMID:[Painless ST segment depression during exercise stress tests in patients after acute myocardial infarct]. 249 Sep 96

To characterize the left ventricular (LV) systolic and diastolic function in elderly hypertensives, mechano-and echocardiography was performed in 27 elderly patients more than 65 years of age (20 hypertensives and 7 normotensives) and 46 middle-aged patients (34 hypertensives and 12 normotensives). In normotensives, a positive correlation was found to exist between age and blood pressure, LV wall thickness, II-RF interval and the A/E ratio, whereas the correlation of age to systolic parameters such as ET/PEP and EF was absent. This suggests that the LV diastolic function was impaired progressively by aging with preservation of the LV systolic function. In elderly hypertensives, LV systolic function was deteriorated and the A/E ratio increased as diastolic blood pressure became elevated. The A/E ratio also increased in this group as compared with that in middle-aged hypertensives, although the differences was not statistically significant. Unlike those in middle-aged hypertensives, the indices of LV function except the elevated blood pressure and the increased cardio-thoracic ratio were not significantly different between hypertensive and normotensive elderly patients. This might be because of the wide range of normal values in elderly persons due to the various degrees of atherosclerotic changes and other pathophysiologic factors, which might have masked obvious characteristics of hypertension in elderly hypertensives.
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PMID:[A noninvasive study on characteristics of the left ventricular function in elderly hypertensive patients]. 261 3


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