Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020538 (hypertension)
 170,190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In the past year 5 patients with uncommon secondary hypertension have been observed at the Medical Clinic, Cantonal Hospital of St Gall, Switzerland. Two patients had generalized neurofibromatosis with specific vascular lesions of the renal arteries, while 3 older patients showed clinical and morphologic signs of repeated renal cholesterol embolization. Experience with these 5 patients shows that angiography should chiefly be used in young patients with suspected secondary hypertension. Older patients with common vascular sclerosis should undergo angiography only where the indication is urgent, in view of the risk of renal cholesterol embolization. In 3 of 5 patients a lasting improvement in hypertension was achieved by antihypertensive drug therapy. Two older patients with cholesterol embolization died from complications such as uremia and therapy-resistant hypertension.
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PMID:[Rare forms of hypertension (neurofibromatosis and cholesterol embolization]. 642 48

Vasculopathy in the syndrome of Von Recklinghausen's neurofibromatosis is a well known but clinically underestimated phenomenon. Its manifestations have included renovascular hypertension, occlusive cerebrovascular disease and visceral ischemia. The progressive arterial disease may involve small vessels on a regular basis and large vessels in a variety of angiographic patterns. A young neurofibromatosis patient is described with an aneurysm of the superior mesenteric artery complicating renovascular hypertension associated with aortic coarctation and renal artery stenosis. This unique angiographic demonstration illustrates the therapeutic dilemmas posed by the vascular disease associated with Von Recklinghausen's neurofibromatosis.
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PMID:Von Recklinghausen's vasculopathy. 642 59

The case is reported of a 16 year-old girl with arterial hypertension, generalized neurofibromatosis, coarctation of the abdominal aorta, bilateral renal artery stenosis, occlusion of the coeliac artery and superior mesenteric artery and kyphoscoliosis.
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PMID:[Combined occurrence of renovascular hypertension, coarctation of the abdominal aorta, occlusion of the celiac and mesenteric arteries and kyphoscoliosis with neurofibromatosis--a case report]. 642 40

On the basis of a personal case and a review of the literature, the authors describe the particular features of the association of neurofibromatosis and pregnancy. With the exception of a few severe forms of the disease, pregnancy is possible in the majority of patients with neurofibromatosis, although there is a risk of hypertension of pregnancy. The rate of abortion is a little higher than in the general population.
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PMID:[Von Recklinghausen's neurofibromatosis and pregnancy and the puerperium]. 644 95

Among neurocutaneous disorders, coarctation of the abdominal aorta and renal artery stenosis have traditionally been associated with neurofibromatosis. We report a 5-year-old girl who, during the evaluation of asymptomatic hypertension, was discovered to have bilateral renal artery stenosis, coarctation of the abdominal aorta, renal cysts and typical skin lesions of tuberous sclerosis. Renal vascular hypertension has not been reported previously in tuberous sclerosis. We conclude that the tuberous sclerosis complex should be expanded to include vascular malformations and that hypertension should not be assumed to be secondary to renal hamartomata or cysts in patients with tuberous sclerosis.
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PMID:Coarctation of the aorta and renal artery stenosis in tuberous sclerosis. 647 22

A case of bilateral renal artery stenosis and aneurysms in association with neurofibromatosis and hypertension is discussed and the literature is reviewed. In patients with neurofibromatosis and hypertension, the association of pheochromocytomas is well known. The association of renal of renal vascular lesions must also be recognized. In children with neurofibromatosis and hypertension, renal artery stenosis is far more common than pheochromocytoma. In adults aneurysms often accompany the renal artery stenosis. Laboratory studies, as well as most intravenous pyelograms, have been normal and, therefore, unreliable for screening. Angiography is essential in the investigation of hypertension in patients with neurofibromatosis.
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PMID:Neurofibromatosis, hypertension, and renal artery aneurysms. 676 66

A child with neurofibromatosis had hypertension and acute hemiplegia resulting from both renal and cerebral vascular occlusive disease. This case illustrates the importance of recognizing surgical antihypertensive therapy was attempted, and may have contributed to rapid neurologic deterioration. Children with neurofibromatosis and hypertension require a careful neurologic evaluation, including computed tomography, before therapy.
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PMID:Childhood hypertensive stroke with neurofibromatosis. 677 Feb 88

A 45-year-old woman had abdominal pain, azotemia, and hypertension. Intravenous pyelography revealed bilateral ureteral compression by extrinsic tumor masses that proved to be neurofibromata by histologic examination. After surgical removal of the tumors, she became normotensive and asymptomatic. In addition, severe medial hypertrophy of veins was seen in the tissue examined. We believe that the latter is most probably related to the neurofibromatosis and is analogous to the hypertrophic arterial changes known to occur in patients with von Recklinghausen's disease.
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PMID:Retroperitoneal neurofibromatosis and venous anomalies. 677 34

A case of a 19-year-old woman with generalized neurofibromatosis and hypertension due to left main renal artery mesodermal dysplasia is presented. Renal artery stenosis was effectively treated with percutaneous transluminal angioplasty. The relevant literature is also reviewed.
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PMID:Percutaneous transluminal renal artery angioplasty in hypertension associated with neurofibromatosis. 678 20

Forty pediatric patients (16 girls and 24 boys) 22 months to 17 years old underwent operation for renovascular hypertension. Ostial stenoses were present in 20 children; midrenal lesions were present in eight; and isolated segmental disease was present in 12 patients and was combined with main renal artery stenoses in three patients. Neurofibromatosis affected ten patients, including three having abdominal aortic anomalies. Abdominal aortic coarctation affected five other children. Hypertensive urograms were abnormal only 27% of the time. Renin assays were helpful in identifying functionally important renal ischemia. Fifty-one primary surgical procedures were undertaken, including one simultaneous and nine staged operations for bilateral disease. There were two primary nephrectomies. Six patients underwent later secondary operations. Thirty-four patient (85%) were cured of hypertension, the conditions of five (12.5%) were improved, and one (2.5%) was classified a therapeutic failure. Carefully performed arterial reconstructive surgery will benefit most pediatric patients with renovascular hypertension.
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PMID:Pediatric renal artery occlusive disease and renovascular hypertension. Etiology, diagnosis, and operative treatment. 678 60


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