Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020538 (hypertension)
 170,190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Acute liver failure is a rare but life-threatening disease that can lead to progressive encephalopathy, intracranial hypertension, and multiorgan failure. In the developed world, the most common cause remains acetaminophen overdose, but there are still many cases in which there is acute liver failure of unknown etiology. The mainstay of acute liver failure management remains supportive care in the critical care setting. If supportive treatment does not stabilize the disease process, the patient may require emergent liver transplantation. This article summarizes the current management of acute liver failure.
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PMID:Modern Management of Acute Liver Failure. 2973 26

Acute liver failure (ALF) is characterized by loss of liver function without pre-existing chronic liver disease. Drug toxicity and viral hepatitis have been identified as the main causes of ALF in Germany. The regeneration capability of the liver and overall prognosis are determined by the underlying etiology. Advances in intensive care medicine, supportive therapy, and transplantation surgery have improved the overall outcome of ALF over the last two decades. The clinical syndrome of ALF is mainly due to a release of inflammatory cytokines from necrotic hepatocytes, which lead to disastrous consequences in the immune system and hemodynamics. The main goals of supportive intensive care therapy in ALF are early identification and treatment of infections and the prevention and therapy of cerebral hypertension.
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PMID:[Acute liver failure]. 3228 44


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