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Query: UMLS:C0020538 (hypertension)
 170,190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The evidence linking psychosocial factors to sustained blood pressure elevation is highly suggestive and comes from a variety of sources. Hypertensives show increased responsiveness to emotional and mental stimuli. The hemodynamic characteristics of unstimulated hypertensives are similar to those of normotensives under emotional stress. It is likely that the sympathoadrenomedullary system partly mediates these responses, but the evidence in humans is mixed. Stranger evidence comes from studies of mice showing that symbolic stimuli in the form of disordered social relations lead to hypertension and increased heart size. In humans, the evidence linking psychological traits to hypertension is inconsistent. The prevalence of hypertension varies by social class and ethnic group and increases with acculturation from rural, traditional to modernized societies. One possible explanation for this is the attendant psychosocial changes. A variety of stress-management techniques have been shown to lower blood pressure, adding weight to a stress hypothesis.
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PMID:Psychosocial factors and blood pressure. 390 28

The clinical picture and investigation of 26 patients (16 males and 10 females) with diagnosis of transient global amnesia (TGA) are reported. Age ranged from 51 to 78 years at the time of TGA, which occurred mor often between 60 and 70 year-old people. Three patients presented more than one episode (3, 4 and 5). Precipitating factors were identified in 8 cases (emotional stress in 7 and physical exercise in 1). Risk factors for cerebrovascular disease were found in 13 cases, mainly hypertension (9 cases) and diabetes (3 cases). EEG was normal in 20 cases and disclosed diffuse delta waves in 2, temporal delta waves in 1 and temporal theta waves in another patient. CAT scan showed no abnormalities in 3 cases and ischemia in the vertebro-basilar system in another 2. Brain angiography was normal in 1 case and showed abnormalities in the vertebro-basilar system arteries in 3. During the follow-up period, which ranged from 1 to 84 months, no neurologic deterioration was seen. The role of risk factors for vascular diseases, epilepsy and migraine in the development of TGA is discussed.
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PMID:[Transient global amnesia: study of 26 cases]. 401 36

A study was made of the effect of chronic emotional stress on the formation of hypertension in animals. This was shown to be related to dynamic changes in the function of the CNS, particularly in the hypothalamic apparatus of the neuroendocrine control. The above changes played a role in the formation of hypertensive vascular reactions accompanied by a high hormonal secretion of the adrenal cortex and thyroid. During stabilization of high arterial blood pressure at the late stages of the "after-effect", the hormonal secretion returns to normal.
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PMID:[Neurophysiological analysis of the development of endocrine and hypertensive reactions in long-term emotional stress]. 404 Jul 80

In experiments on alert cats shifts of the systemic hemodynamics under emotional stress were studied. The hypertension caused by confrontation with a dog is shown in most cases to be attended by suppression of the baroreceptor reflexes. Hypertension does not develop in these animals after section of the sinocarotid and aortic nerves. In 2 cats the baroreceptor reflexes did not change under emotional stress and deafferentation of the carotid sinuses and arch of the aorta intensified hypertension upon confrontation with a dog. It is concluded that diverse mechanisms lead to hypertension under emotional stress in different animals.
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PMID:Mechanisms underlying hypertensive reactions under emotional stress. 404 Oct 17

Blood pressure variability under basal conditions and blood pressure reactivity to emotional stress were studied in 38 hypertensives and 13 normotensives. Systolic basal blood pressure variability correlated with systolic blood pressure reactivity. Variability increased with higher basal blood pressure. Thus in the hypertension group the blood pressure variability was greater than in the normotension group. Besides, the hypertension group showed a greater reactivity of systolic blood pressure to emotional stress, too. An influence of age on basal blood pressure, blood pressure variability, and reactivity could be evaluated; but no influence of sex on these parameters was detected. The results indicate that variability and reactivity of blood pressure can be referred to a common central nervous blood-pressure-regulating mechanism. As both parameters are increased in hypertension, a greater lability of blood pressure must be assumed. This greater lability may be attributed to a stronger neurogenic influence or to structural changes of peripheral blood vessels.
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PMID:Basal blood pressure variability and reactivity of blood pressure to emotional stress in essential hypertension. 653 92

The hemodynamic response to emotional stress (mental arithmetic) was studied in ten borderline and ten mild hypertensives in comparison to ten age-matched normotensives. Due to emotional stress the blood pressure increased in all three groups; its rise was greater in borderline and mild hypertension. After stress, the blood pressure also remained elevated longer in the hypertensive groups. The increased blood pressure reaction was accompanied by a greater rise of heart rate and cardiac output. The increase of cardiac output correlated with the blood pressure elevation. Stroke volume changed in comparison to the pre-stress period only in the mild hypertension group. Total peripheral resistance decreased slightly in all three groups. No significant differences between the groups could be found in regard to stroke volume and total peripheral resistance. The cardiovascular hyperreactivity in early hypertension is attributed to a stronger sympathetic stimulation of the circulation. The hemodynamic pattern indicates an increased beta-adrenergic stimulation of the heart as the main pathological mechanism.
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PMID:Hemodynamics during emotional stress in borderline and mild hypertension. 665 92

Some circulatory parameters were examined, using tetrapolar chest rheography and rheoencephalography, in patients with essential hypertension of stages I-II during emotional stress after oral administration of 5 mg seduxen. Seduxen was not shown to prevent hypertensive response to emotional stress. In the post-stress recovery period, this drug reduces the duration of hypertension. Seduxen is conducive to redirecting the trends of hemodynamic response of hypertensive patients so that it becomes similar to that of normal subjects. In patients with hypokinetic response to emotional stress, seduxen restores the autoregulation capacity of cerebral vessels.
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PMID:[Effect of seduxen on stress-induced hemodynamic reactions in patients with hypertension]. 685 68

There is an abundance of information suggesting that prostaglandins are involved in the development and clinical expression of atherosclerosis. Many studies demonstrate a relationship between prostaglandins and the risk factors for peripheral and coronary artery disease. Thus, part of the mechanism by which hyperlipidemia, diabetes mellitus, smoking, hypertension, sex hormones, age, heredity, emotional stress and diet contribute to the development and progression of atherosclerosis may be through an imbalance between thromboxane A2 and prostaglandin I2. Recent studies show a temporal relationship between acute ischemic events (specifically, unstable angina) and a transcardiac increase in thromboxane B2, while others demonstrate a salutary effect of disaggregatory and vasodilatory prostaglandins in such patients. If prostaglandins and thromboxane prove important in ischemic vascular disease, attention will be directed at the correction of their pathologic imbalance. This may be accomplished by dietary manipulation as well as by the development of prostaglandin receptor antagonists or inhibitors of specific prostaglandin pathways.
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PMID:Prostaglandins and ischemic heart disease. 703 86

In this investigation, 30 male post-myocardial infarction patients and 30 male control subjects matched according to age and occupation were given a 12-minute tape-recorded stress quiz described by Schiffer et al. Cardiovascular responses (electrocardiogram, heart rate, systolic, blood pressure, and diastolic blood pressure) to emotional stimuli were monitored in a laboratory setting at rest before the quiz and at two-minute intervals during the quiz. Heart rate and blood pressure values were significantly higher during the quiz than at rest for both patient and control groups. There was a significantly higher response for diastolic pressure and a significantly lower response for heart rate in the patient group compared with the control group. In the analysis for occupational status in the entire population, systolic pressure was significantly higher for the executives than for non-executives. Subgroup analyses of patients with angina, hypertension and/or ECG changes (N = 12) revealed a significantly higher diastolic pressure response than found in either the patients without these symptoms (N = 18) or in the controls (N = 30). In comparison to exercise test results, the emotional stress test (quiz) elicited somewhat more PVC's but less ST segment depression. These results support previous reports suggesting that emotional stress testing may be a valid tool in the diagnosis of coronary heart disease and in determining the physiological mechanisms which underlie the association between emotional stress and coronary heart disease.
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PMID:Cardiovascular responses to emotional stress (quiz interview) in post-myocardial infarction patients and matched control subjects. 705 23

The cardiovascular reactions to experimentally produced emotional stress were studied. Stress was produced by restraint and/or electrical stimulation of the hypothalamic defense area in mobile or immobilized animals (rats and rabbits). It was found that some strains and individuals were quite resistant to these forms of stress manifesting little if any cardiovascular disturbances. Others showed early rises in heart rate, blood pressure, etc. but soon adapted and suffered no severe damage. A third category was comprised of sensitive strains and individuals which when thus exposed to stress developed hypertension, cardiac failure and some even failed to survive the test experience. These observations, those of others working in this field, and the implications of these findings are discussed.
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PMID:Organization of cardiovascular functions under experimental emotional stress. 727 48


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