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Query: UMLS:C0020538 (hypertension)
 170,190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The central noradrenaline (NA) and adrenaline (A) turnover in 15--16-week-old stroke prone, spontaneously hypertensive (sp-SH) female rats in an advanced stage of hypertension was found to differ from that of normotensive Wistar-Kyoto (WKy) control rats. The catecholamine (CA) levels were measured after inhibition of dopamine-beta-hydroxylase (DBH) or phenylethanolamine-N-methyltransferase (PNMT). in the hypertensive rats the dopamine (DA) and NA levels and the NA turnover were reduced in the hypothalamus, while in the dorsal part of the caudal medulla oblongata NA levels and A turnover were reduced. Changes in hypothalamic DA and NA mechanisms and in A mechanisms in medulla oblongata may therefore be of importance in the blood pressure regulation of sp-SH rats.
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PMID:Catecholamine turnover changes in hypothalamus and dorsal midline area of the caudal medulla oblongata of spontaneously hypertensive rats. 53 May 33

Over the past three years, high-dose barbiturate therapy has been used in the treatment of 60 patients with head injury (N = 45), encephalitis (N = 8), acute focal cerebral ischemia (stroke, N = 4), and global anoxia secondary to drowning (N = 3). High-dose barbiturates appear to be useful adjuncts in the control of intracranial hypertension refractory to other methods of therapy. Administration of barbiturates to patients with this problem will often reduce the requirement for osmotic agents, thereby facilitating medical management by avoiding hyperosmolality and fluid and electrolyte depletion. In a carefully controlled intensive care setting the risk of barbiturate therapy is low, though the costs and demands on personnel are great. Survival appeared to be improved in aptients with ,head injury and encephalitis. Although the ultimate outcome was not altered in patients with stroke or near-drowning, intracranial hypertension did not occur until barbiturate therapy was withdrawn. This experience provides an ethical basis to justify further randomized studies for determining whether or not barbiturates materially improve the neurological outcome following cerebral ischemic and traumatic insults.
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PMID:High-dose barbiturate therapy in humans: a clinical review of 60 patients. 53 17

Regular biennial health screenings of the Busselton population between 1966-75 resulted in the recognition of individuals with hypertension and a progressive increase in the adequacy of control of blood pressure in those on treatment. Between 1973-77 observed mortality from strokes (CVA) in males 50 yrs and over declined significantly as might be expected from the smaller numbers at risk from raised blood pressure. No favourable trends occurred in the incidence of CVA in women despite better control of hypertension. In the population as a whole, CVA mortality in untreated or inadequately controlled hypertensives was significantly greater than in normo-tensives or adequately controlled hypertensives.
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PMID:Changing mortality due to strokes in men following treatment of Busselton hypertensives 1967-77. 53 91

1. Arterial plasma catecholamines and haemodynamic status were simultaneously studied in 27 patients with fixed essential hypertension (WHO I-II). 2. Total arterial plasma catecholamines were found to be directly related to mean arterial pressure and to calculated total peripheral resistance, and they were inversely related to stroke index. 3. The degree of total peripheral resistance reduction after alpha-receptor blockade (phentolamine 10 mg intravenously) and the degree of mean arterial pressure reduction after combined alpha- and beta- receptor blockade (labetalol 100 mg intravenously) were directly related to pretreatment plasma catecholamine concentrations. 4. These findings support the view that the sympathetic nervous system, as evaluated by plasma catecholamine concentration, may have an important role in maintaining hypertension in a subgroup of patients, contributing mainly to the degree of peripheral vasoconstriction.
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PMID:Catecholamines and haemodynamics in fixed essential hypertension. 54 Apr 29

1. Neonatal sympathectomy with 6 hydroxy-dopamine (6-OHDA) was used as a tool to assess the significance of an increased sympathetic vascular tone for the development of high blood pressure in stroke-prone spontaneously hypertensive rats. After administration of 6-OHDA the rise in blood pressure was blunted for the following 9 weeks until innervation was re-established. 6-OHDA-treated rats retained more sodium and had larger plasma and blood volumes than sham-treated rats. 2. Catecholamines in plasma were increased 2-10-fold immediately after sympathectomy, but their concentrations were subnormal on day 7. Eight weeks after sympathectomy plasma noradrenaline and dopamine were not elevated, but plasma adrenaline has increased twofold. 3. The reactivity of resistance vessels to noradrenaline was markedly enhanced and the neuronal uptake and metabolism of noradrenaline were still reduced 8 weeks after neonatal sympathectomy. 4. These results confirm the significance of an intact sympathetic nervous system for the development in these rats. Sodium retention and increased plasma and blood volume may be considered as a compensatory mechanism for the vasodilatation resulting from decreased vasomotor tone.
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PMID:Effect of neonatal sympathectomy by 6-hydroxydopamine on volume and resistance regulation in stroke-prone spontaneously hypertensive rats. 54 Apr 31

1. Alterations in vascular reactivity were assessed in isolated artificially perfused kidneys from stroke-prone spontaneously hypertensive (spSH) rats at different stages of hypertension and after neonatal sympathectomy with 6-hydroxydopamine (6-OHDA). 2. During the pre-hypertensive stage, and the early and chronic stages of hypertension, the responses to noradrenaline, vasopressin, serotonin and angiotensin II were enhanced in renal vascular beds from spSH animals compared with age- and sex-matched Wistar-Kyoto (WK) rats; dose-response curves were shifted to the left, had steeper slopes, greater maximal responses and decreased thresholds. 3. With increasing severity and duration of hypertension, renal vascular resistance at maximal vasodilatation increased, the slopes of the dose-response curves were steeper and maximal responses were greater. 4. Neonatal sympathectomy with 6-OHDA greatly attenuated but did not prevent the eventual development of hypertension; furthermore, this treatment had no effect on the enhanced resistance or reactivity in renal vascular beds from spSH rats. 5. The appearance of enhanced resistance and reactivity in the early stages of hypertension and the inability to prevent these vascular changes by neonatal sympathectomy suggest that these alterations are a primary pathogenic mechanism in spSH rats.
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PMID:Vascular reactivity in the pathogenesis of spontaneous hypertension. 54 Apr 70

The hemodynamic alterations associated with the developmental phase of high blood pressure were investigated in the spontaneously hypertensive rat (SHR). All hemodynamic measurements were made in unanesthetized, unrestrained SHR and Wistar-Kyoto (WKY) rats instrumented with chronic electromagnetic flow probes on the ascending aorta and arterial pressure catheters. Rats were studied at 30-41 days, 80 days, and 120 days of age. Hemodynamics of SHRs and WKYs in the 30-41 day group were monitored daily. Spontaneously hypertensive rats demonstrated a higher cardiac index than WKYs (p less than 0.05) from 32 through 41 days of age. Total peripheral resistance (TPR) was not elevated in SHRs at this time. Heart rate and stroke index were elevated in SHRs (p less than 0.05) from 34 through 41 days, however, stroke volume was not. At 80 and 120 days SHRs had higher mean arterial pressure (MAP) and TPR than WKYs (p less than 0.05), although cardiac index was not significantly different. This hemodynamic pattern of a hyperkinetic circulation prior to the development of hypertension supports the theory of total body autoregulation. A transient increase in cardiac index precedes an increase in TPR, which then normalizes cardiac index while elevating MAP.
Hypertension
PMID:Central hemodynamics in the developmental stage of spontaneous hypertension in the unanesthetized rat. 54 Oct 42

A total of 251 young patients (less than 40 years) with stroke were admitted during a 7-year period and investigated. These constituted 30% of the total stroke patients admitted to this hospital. Among the young, 63% of strokes were of nonembolic occlusive group. Hemorrhagic strokes were observed in 26% cases. This study revealed that concurrent infection, nonspecific arteritis, diabetes mellitus and hypertension contribute very little to the stroke in younger population. However, cholesterol, beta-lipoproteins, triglycerides, platelet adhesiveness and platelet aggregation were significantly increased in some of the clinical groups.
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PMID:Clinical features and risk factors in stroke in young. 54 89

By the combination of radiocardiography, ergooxytensiometry and heart probing on 22 lobectomized, cone- and segment-resected patients, respectively could be established in comparison to control groups that also after parenchyma-saving lung resection a pulmonary load parenchyma-saving lung resection a pulmonary load hypertension develops in 15 patients. The sequel of this increase of pressure and resistance in the pulmonary circulation is a functional insufficiency of the heart in 11 cases which is to objectify by reduction of the stroke volume, increase of the end-diastolic and end-systolic volume and by reduction of the contractility of the myocardium.
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PMID:[Cardiopulmonary function after segmental resection of the lung]. 55 Jun 19

The cardiovascular responses to acute mental "stress" were compared in the Milan strain of spontaneously hypertensive rats (MHS) and in normotensive control rats (NR). Blood pressure and heart rate were followed in pairs of awake MHS and NR, while defence reactions were provoked by alerting stimuli (noise, vibration). No differences were noted between the two groups in response to "stress" although resting heart rate in MHS was lower than in NR. Administration of atropine or propranolol to MHS and NR showed the MHS to have a higher resting vagal tone and lower sympathetic tone than the NR. Subsequent (at least two weeks later) hemodynamic investigation, under nembutal anesthesia, showed no difference in cardiac output between MHS and NR but a higher stroke volume, presumably related to the lower heart rate in MHS. Thus, total peripheral resistance was increased in MHS as was the ratio left ventricular weight/body weight, and in good proportion to the blood pressure rise. Thus MHS differ substantially in both their responses to "stress" and also hemodynamically from the Okamoto strain of spontaneously hypertensive rat (SHR), being the so far most studied and best known model of essential hypertension in man. In MHS the hypertension is more of a systolic type and is of primarily renal origin. As such, MHS provide another model for investigating the polygenic nature of hypertension in man.
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PMID:Cardiovascular control in the Milan strain of spontaneously hypertensive rat (MHS) at "rest" and during acute mental "stress". 55 79


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