Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0020538 (hypertension)
 170,190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effects of alcohol on the heart include modification of the risk of coronary artery disease, the development of alcoholic cardiomyopathy, exacerbation of conduction disorders, atrial and ventricular dysrhythmias, and an increased risk of hypertension, hemorrhagic stroke, infectious endocarditis, and fetal heart abnormalities.
West J Med 1989 Oct
PMID:Cardiovascular effects of alcohol. 268 74

The prevalence of open-angle glaucoma is believed to be very high among West Indian blacks. To begin investigating the prevalence and risk factors for glaucoma and other eye diseases in Barbados, WI, a pilot study was conducted. The pilot project identified a stratified, random national sample of 300 persons over 35 years of age who were invited to participate in an ophthalmic examination and an interview. Of those contacted 89% were eligible and 95% of these agreed to participate. The overall glaucoma prevalence in the participants was 6%; it was 13% among black and mixed persons over 54 years. Age related cataract, hypertension, and diabetes were frequent findings. Although the sample size of the pilot project is small, the results suggest a high prevalence of glaucoma in Barbados, a finding that merits further study.
 ...
PMID:A pilot project of glaucoma in Barbados. 273 Aug 59

Serum lipids, lipoproteins, and major apolipoproteins and their association with previous myocardial infarction were studied in patients with non-insulin-dependent diabetes mellitus (NIDDM) and nondiabetic subjects in East and West Finland in 1982-1984. NIDDM patients had higher age-adjusted serum triglyceride and apolipoprotein B levels and a higher apolipoprotein B/apolipoprotein A-I ratio, lower serum high density lipoprotein (HDL) cholesterol and apolipoprotein A-1 levels, and a lower HDL cholesterol/apolipoprotein A-1 ratio than nondiabetic subjects. With a few exceptions, these differences persisted after adjustment for body mass index, alcohol intake, physical activity, smoking, and hypertension, which suggests that the atherogenic serum lipoprotein pattern in NIDDM is an inherent feature of the disease. In general, the association of serum lipids, lipoproteins, and apolipoproteins with myocardial infarction was similar in nondiabetic subjects and NIDDM patients, although it was somewhat stronger in the diabetic subjects. A low serum HDL cholesterol/apolipoprotein A-1 ratio, which was closely linked to high serum triglyceride level, seemed to be more consistently related to myocardial infarction in NIDDM patients than in nondiabetic subjects. Serum lipids, lipoproteins, and apolipoproteins, either separately or in various combinations, could only to a small extent explain the higher prevalence of myocardial infarction in diabetic subjects compared with nondiabetic subjects when tested in multivariate analysis with other cardiovascular risk factors as background variables. The association between serum lipoproteins and myocardial infarction was largely similar in East and West Finland, two areas that differ markedly with respect to the occurrence of coronary heart disease.
 ...
PMID:Serum lipids, lipoproteins, and apolipoproteins and the excessive occurrence of coronary heart disease in non-insulin-dependent diabetic patients. 277 12

Analyses of data from the first National Health Examination Survey undertaken from 1984-1986 within the framework of the German Cardiovascular Prevention Study, show the following risk factor prevalences in 25-69 year-old men and women: overweight (BMI males: greater than 25, females greater than 24) or obese (BMI greater than 30): men 65.0%, women 57.6%; total serum cholesterol (less than 5.17 mmol/dl): men 73.7%, women 74.0%; normal blood pressure (according to JNC definitions): men 45.0%, women 59.1%; hypertension according to WHO criteria: men 26.0%, women 21.1%; controlled hypertensives (WHO criteria): men 19.9%, women 33.9%; current smoking: men 40.8%, women 26.1%. For most of the cardiovascular risk factors there is a clear negative association between prevalence and length of school education. Three myocardial infarction (MI) registries (WHO MONICA Project) are operating in the Federal Republic of Germany. Incidence and case-fatality data are within comparable ranges. Coronary heart disease (CHD) mortality has been relatively stable in both sexes from 1970 to 1986 with a minor peak in 1976 and a slight downward trend since then. A study of the reliability of coding procedures in West German state statistical offices revealed major disagreements so that trends derived from national mortality data as aggregate data of the federal states might be spurious. An ecological correlation of regional smoking prevalences (1978) and regional CHD mortality rates (1977-9) showed significant coefficients in men, but not in women.
 ...
PMID:Cardiovascular disease risk factors, CHD morbidity and mortality in the Federal Republic of Germany. 280 91

Maternal endoxin (digoxinlike substance) is proposed as arising in the fetal area of the fetal adrenal cortex. Its function may be to sensitize the uterus for labor, much as does cortisol in the sheep fetus. Because endoxin is a sodium-potassium-adenosine triphosphatase inhibitor, however, it may also induce maternal vasoconstriction. On our service, normal pregnant women have detectable endoxin after 35 weeks with increasing amounts at term. Specimens of cord blood often have "digoxin" in the therapeutic range. We find that about 40% of women in premature labor and 65% of pregnant women with hypertension have elevated levels of serum endoxin. Postdate gravid women sometimes have very low endoxin levels. Pregnant women with complications and elevated digoxin (endoxin) levels could have specific antidigoxin therapy if endoxin proves to be a modulator of their symptoms. Digoxinlike substances are also sometimes elevated in ill nonpregnant persons, such as those with renal, liver, or heart failure, or hypertension.
West J Med 1988 May
PMID:Fetal endoxins and complications of pregnancy. 284 75

Excess salt consumption has been implicated in the rising prevalence of essential hypertension in West Africa. It has been suggested that low supplies of salt in West African history were responsible for a genetic mutation that predisposes Blacks to high blood pressure. However, historical evidence concerning salt supplies in West Africa suggests that availability was not uniform. For instance, in Senegal and Gambia salt production has been extensive since ancient times, whereas in ancient Nigeria the population had to depend on local vegetables salts or meagre imports of the mineral. Reports that blood-pressures in Senegalese and Gambians are lower than those in Nigerians may be a reflection of historical differences in salt supply. The difference in blood pressure between members of a racial group also casts serious doubt on the concept of racial homogeneity often accepted in the medical sciences, and the relation between blood-pressure and salt availability in West Africa reveals that insights can be obtained from a study of history.
 ...
PMID:History of salt supplies in West Africa and blood pressures today. 287 Feb 76

High rate of arterial hypertension occurrence in Leningrad and North-West of Europe is supposed to be associated with some ecological factors (soft water with low quantity of minerals) aiding the action of some main etiological factors of the hypertension. Some clinical-physiological approaches to solution of the problem are suggested.
 ...
PMID:[Ecologo-physiologic aspects of the occurrence of arterial hypertension in Leningrad (facts and hypotheses)]. 297 89

During a 12-month period, 54 infants with the West syndrome (10 idiopathic, 44 symptomatic) referred to 10 major children's hospitals for initial treatment were evaluated to obtain comprehensive data on clinical findings and current treatment modalities. Prominent features included prevalence of prenatal and perinatal etiologies, severe neurological deficits and disturbed psychomotor development as well as patient-specific spectrum of seizure manifestations. Characteristic behavioural abnormalities before onset of spasms are an early indicator for the West syndrome. Therapeutic management varied considerably. Response to ACTH/steroid regiments was more favourable than to non-ACTH/steroid regimens. The most frequent serious adverse reactions during the initial treatment period were arterial hypertension and infections. Improved therapeutic strategies based on detailed initial patient assessment and systematic monitoring of beneficial effects and adverse reactions are necessary for future trials.
 ...
PMID:Preliminary report of a multi-center study on the West syndrome. 306 26

The potential efficacy of preventive interventions in Latin America to reduce perinatal morbidity and mortality is reviewed. The most important perinatal risk factors associated with pregnancy and delivery are young age of the mother, low socioeconomic status, low education, malnutrition, lack of prenatal care, pregnancy-induced-hypertension, perinatal infections, alcohol, smoking, and iatrogenic causes. Adequate data are lacking to determine the magnitude of these factors in Latin America. Iatrogenic causes of perinatal morbidity are increasing because of the tendency to institute neonatal intensive care before improvement in medical and nursing staff and procedures. Specific programs that have been effective include the 30-year effort in Chile to reduce the incidence of low birth weight. Infant death rates in Latin America fell between those in Asia and the West, correlated with the occurrence of low birth weights. Nutritional programs are mixed in their effect: they do not necessarily help unless targeted at women with clinical malnutrition or history of LBW or IUGR; they can harm overall food production in the community. Increasing institutionalization of labor and delivery is a mixed blessing. Efforts in Guatemala to reverse the worst aspects of hospital delivery have improved pregnancy and labor outcomes. These include permitting fathers to attend births, allowing women to deliver in kneeling position, and encouraging infant bonding and breast feeding. Other effective interventions include mothers meetings to encourage prenatal care, and detection and referral of high risk cases in a regionalized system of care.
 ...
PMID:Emphasis on preventive perinatology: a suitable alternative for developing countries. 306 47

Obesity--defined by a body mass index above 30 kg per m2--is a major problem for affluent nations. Its prevalence is higher in North America than in Europe--between 9% and 12% of the population. Reduced energy expenditure from exercise or metabolism or both may be an important contributory factor in the development of obesity because of a failure to reduce food intake sufficiently to maintain energy balance. A high ratio of abdominal circumference relative to gluteal circumference carries a twofold or greater risk of heart attack, stroke, hypertension, diabetes mellitus, gallbladder disease, and death. The effect of increased quantities of abdominal fat is greater than that of a similar increase in total body fat on the risks of ill health associated with obesity. Genetic factors appear to contribute about 25% to its etiology.
West J Med 1988 Oct
PMID:Obesity. Part I--Pathogenesis. 306 47


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>