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Query: UMLS:C0020538 (hypertension)
 170,190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Benign intracranial hypertension is known to be associated with obesity, endocrine abnormalities, various medications, and cerebral venous sinus thrombosis. We report a patient presenting with headaches and vomiting attributed to benign intracranial hypertension. The diagnostic work-up revealed Langerhans' cell histiocytosis of the occipital bone. There was no evidence for cerebral vein thrombosis by cranial computed tomography scan, Doppler ultrasonography, planar and single photon emission computed tomography technetium 99m-labelled red blood cell scintigraphy, and magnetic resonance angiography. Excision of the occipital bone lesion and a short course of acetazolamide and prednisone were curative. We hypothesize that cytokines secreted by the tumor were responsible for the development of intracranial hypertension.
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PMID:Langerhans' cell histiocytosis presenting as intracranial hypertension. 1141 6

Oral budesonide in adult studies is a potent corticosteroid with decreased systemic bioavailability and an improved adverse effect profile in comparison with prednisone. It has recently been introduced for the treatment of inflammatory bowel disease in Europe, Canada, and Israel. Benign intracranial hypertension has rarely been associated with corticosteroid therapy but has not been reported in association with budesonide therapy. Three adolescents with Crohn's disease and poor nutritional status developed benign intracranial hypertension while receiving oral budesonide. All three patients had previously received multiple courses of prednisone during the course of their disease, without developing intracranial hypertension. Benign intracranial hypertension resolved after medication withdrawal and did not recur with subsequent use of prednisone. Evaluation for benign intracranial hypertension should be considered in patients with inflammatory bowel disease who develop headache while receiving oral budesonide. This side effect may be associated with poor nutritional status.
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PMID:Benign intracranial hypertension associated with budesonide treatment in children with Crohn's disease. 1141 18

Pseudotumor cerebri or benign intracranial hypertension is a syndrome of raised intracranial pressure without obvious explanation. Most patients are obese women at childbearing age. Symptoms and signs usually include headache, nausea, vomiting, edema of the papilla, visual obscurations and rarely palsy of the nervus abducens. The prognosis is generally good, but progressive visual loss and eventual blindness are major risks. We report the case of a 21-year-old non-obese young woman who developed pseudotumor cerebri while taking minocycline for acne therapy. Identical symptoms occurred upon inadvert rechallenge with minocycline for the second time.
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PMID:[Pseudotumor cerebri in minocyline treatment]. 1168 Jan 22

Pseudotumor cerebri is a condition of intracranial hypertension without localizing signs except for papilledema with normal intracranial contents and normal cerebrospinal fluid constituents. It is seen more frequently in women than in men (8:1) especially women are of childbearing age, and in 90% of cases of obesity. The most common symptoms are headache and visual obscuration. Other symptoms include pulsatile tinnitus, shoulder and arm pain. The papilledema present in almost all PTC patients can lead to decreased vision and blindness. One third of the large series had substantial visual loss including loss of visual field. Treatment has been directed toward preserving vision. Medications that reduce intracranial pressure such as diuretics like Acetazolamide have some success. When vision is threatened, these individuals may undergo optic nerve sheath decompression or lumbar peritoneal shunt to preserve vision. Even with prompt intervention, visual loss can occur.
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PMID:[Pseudotumor cerebri (PTC--an update)]. 1194 27

Idiopathic intracranial hypertension (IIH) is a disorder of increased intracranial pressure that may have papilledema with normal imaging study results. Headache is the most frequent symptom. Although the headache characteristics are indistinguishable from the symptoms of migraine headache, accompanying symptoms of increased intracranial pressure, such as pulsatile tinnitus, transient visual obscurations, and radicular neck pain, may aid in the diagnosis. Magnetic resonance imaging, including venography, is essential for the diagnosis of the primary idiopathic intracranial hypertension. Medical treatment for the headache includes weight loss for obese patients, diuretic therapy, and migraine preventive medications. If medical therapy does not abolish the headache, surgical options should be considered. Because patients with IIH have a poor quality of life, patient education and supportive materials are important.
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PMID:Idiopathic intracranial hypertension headache. 1200 93

The aim of this study was to determine the features of pseudotumor cerebri or idiopathic intracranial hypertension in prepubertal and pubertal children. We retrospectively reviewed patient charts of those 16 years and younger, diagnosed with pseudotumor cerebri/idiopathic intracranial hypertension. Our study group consisted of 27 patients; the mean age was 10.9 years, and there was a male-to-female ratio of 13 to 14. In the prepubertal group (n = 13), the male-to-female ratio was 8 to 5; in the pubertal group, (n = 14), the ratio was 5 to 9. Overweight or obesity was found in 16 (59%) patients. Outcome was favorable except for one who remained symptomatic. Pseudotumor cerebri/idiopathic intracranial hypertension in children is rare. Its characteristics differ from adults. We found the prepubertal group to be a distinct group since pseudotumor cerebri/idiopathic intracranial hypertension did not occur predominantly in females and was not associated with obesity.
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PMID:Idiopathic intracranial hypertension in the pediatric population. 1288 85

Pseudotumor cerebri (PC) is a syndrome characterized by intracranial hypertension in the absence of any space-occupying lesion, hydrocephalus, cerebral sinus thrombosis and biochemical or cytological abnormalities in the CSF. PC has ben associated with several factors such as systemic conditions or drugs. We report here the case of a patient who presented with headache, vomiting and blurred vision accompanied by bilateral papilledema and had been diagnosed with systemic lupus erythematosus (SLE) seven years before. Treatment was started with high-dose corticosteroids with rapid resolution of the clinical symptoms and papilledema of the patient.
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PMID:[Pseudotumor cerebri and systemic lupus erythematosus]. 1260 79

Pseudotumor cerebri is defined and the general pathology added where the idiopathic intracranial hypertension syndrom can be found. The paper reviews the consequences that the increase in cerebral spinal liquid (CSL) pressure has on the visual function. The symptomatology is polymorphous, hard to frame and much more difficult to cure, the diagnosis being one of exclusion.
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PMID:[Pseudotumor cerebri or idiopathic cranial hypertension. Neuro-ophthalmologic considerations]. 1272 89

Idiopathic intracranial hypertension (IdICH) is a high intracranial pressure and no evidence of intracranial lesions or hydrocephalus. The characteristics of IdICH and the anatomical and physiological data show that the mechanisms of elaboration of the interstitial fluid at blood-brain barrier (BBB) and of cerebrospinal fluid (CSF) at choroid plexus are very similarly. In IdICH many pathological conditions can induce the simultaneous hypersecretion of CSF and of the brain interstitial fluid and the high intracranial pressure (ICP) of CSF is equalized simultaneously of the pressure of the brain interstitial fluid. The cerebral blood flow is maintained quasinormal in IdICH, even increased, so that it occurs a fast absorption of CSF and of interstitial fluid and the brain injury is insignificantly despite the high ICP. Therefore idiopathic intracranial hypertension occurs through simultaneous hypersecretion of the cerebrospinal fluid and of the cerbral interstitial fluid followed by a rapid circulation and absorption of these fluids based on a fast cerebral blood flow.
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PMID:Simultaneous hypersecretion of CSF and of brain interstitial fluid causes idiopathic intracranial hypertension. 1459 82

Idiopathic intracranial hypertension in children is rare. We analyzed clinical presentation and outcome in eight patients (six girls and two boys) diagnosed with idiopathic intracranial hypertension. The mean age was 11.1 years. The most common clinical features were headache, papilledema and visual disturbance (visual loss and diplopia). Response to treatment was satisfactory in all patients except one who presented almost complete bilateral amaurosis requiring extracranial shunting and who later developed optic atrophy. Outcome is usually is benign, but given the possibility of severe loss of visual function, close ophthalmic follow-up is recommended until complete resolution.
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PMID:[Idiopathic intracranial hypertension: clinical features and outcome]. 1463 26


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