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Query: UMLS:C0020538 (hypertension)
 170,190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Post thrombotic syndrome (PTS) is a common chronic complication of deep venous thrombosis (DVT). PTS has a negative impact on quality of life. Patients with a more serious form of this syndrome have increased rates of sick leave and incur increased medical costs. The underlying processes leading to PTS are not yet fully understood. Pressure increases in the deep-venous system, resulting in venous hypertension. Venous hypertension is the cause of the most important symptoms of PTS: pain, oedema and skin abnormalities. Compression therapy reduces oedema and pain in patients in the acute phase following DVT. Based on convincing results from randomised trials, elastic compression therapy was recommended for patients with DVT for many years, in order to prevent venous hypertension and PTS. Recent studies have led to discussion on the added value of elastic compression.
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PMID:[Post thrombotic syndrome: are elastic stockings on their last legs? The role of compression in prevention and treatment]. 2599 Mar 32

Postthrombotic syndrome (PTS) is a chronic complication of deep vein thrombosis (DVT) that develops in 20-50% of patients. PTS manifests as a spectrum of symptoms and signs of chronic venous insufficiency that can impose significant morbidity and have a negative impact on quality of life. Chronic venous hypertension caused by a combination of residual venous obstruction and valvular reflux is believed to play a major role in the pathophysiology of PTS. The Villalta scale is the most widely applied clinical scale used to diagnose and define PTS. Proximal DVT and recurrent ipsilateral DVT are the two principal established risk factors for PTS, and efforts in recent years have been focused on identifying a combination of clinical and biomarker predictors that will define high-risk patients and possibly new therapeutic targets. The best way to prevent PTS is to prevent the occurrence of DVT, and to provide optimal anticoagulation for the acute phase of DVT once it occurs. Recent years have brought progress in our understanding of the role of endovascular techniques in the prevention and treatment of PTS and the subgroups of patients that may benefit from these modalities. Pharmacomechanical catheter-directed thrombolysis is the most promising interventional modality for prevention of PTS. This review summarizes the current state of evidence on PTS of the lower limbs, and highlights areas where uncertainty still exists that require further research.
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PMID:The postthrombotic syndrome: current evidence and future challenges. 2786 Jan 29

Postthrombotic syndrome (PTS) is the most common complication after iliofemoral deep vein thrombosis. It reduces quality of life and increases deep vein thrombosis (DVT)-related costs. The clinical symptoms and severity of PTS may vary; the most common symptoms include edema, pain (venous claudication), hyperpigmentation, lipodermatosclerosis, and ulceration. PTS is based on the principle of outflow obstruction, which may be caused by venous hypertension and may lead to valvular damage and venous reflux or insufficiency. Recent technical developments and new stent techniques now allow recanalisation of even complex venous outflow obstructions within the iliac vein and the inferior vena cava. This manuscript gives an overview on the latest standards for venous recanalisation.
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PMID:Standards for recanalisation of chronic venous outflow obstructions. 2991 74


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