Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020538 (hypertension)
 170,190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

HLA antigen frequencies were determined in patients who had suffered adverse reaction to the beta-adrenergic blocking agent, practolol. No statistically significant differences were observed between these patients and control groups. The latter were selected to include two separate groups, normal random healthy population controls, and controls who had taken practolol with no apparent adverse effects. Patients suffering from the very severe form of reaction, sclerosing peritonitis, were analysed separately from those with other lesion e.g. ocular symptoms, but did not show any significant differences. Altered HLA antigen frequencies were observed for those control patients whose primary diagnosis was hypertension but this was considered to be due to selection bias.
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PMID:Adverse reactions to practolol: some observations on the possible relevence to immune mechanisms. 8 Jan 39

Between 1967 and 1977, 1500 children with malformations of the urinary tract were operated upon at the paediatric surgical department of the University of Tubingen. Ten children died in the early postoperative period or later on: Two patients died after operative correction of bladder extrophy following pneumonia and pyelonephritis and uraemia and urinary infection respectively. One child with a myelomeningocele had an ileal conduit performed and died two days after operation of peritonitis and urinary ascites. Two older children with reflux died in spite of successful ureteroneocystostomy, one following a cerebral haemorrhage and the other because of hypertension and uraemia. Five children with mechanical urinary obstruction died after discharge of uraemia and urinary infection. The following reasons for the deaths could be found: -- In two cases wrong indication for operation. -- In one case a technical fault at operation. -- In two cases the diagnosis was made too late. -- In five cases the wrong type of operation was used.
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PMID:Malformations of the urinary tract. 52 62

Eleven patients were treated with continuous ambulatory peritoneal dialysis (CAPD) for periods of 2-7 months (48 patient-months). Clinical and biochemical control of uremia was adequate in all patients. Control of hypertension and serum phosphate level was easier than with previous intermittent peritoneal dialysis (IPD). Mean protein loss during CAPD was 9.7 +/- 2.7 g/day. Seven episodes of peritonitis occurred in 3 patients (1 peritonitis/6.8 months). General use of CAPD cannot be recommended until the high incidence of peritonitis is reduced by urgently needed technical improvements. A potential complication of CAPD was that triglycerides were markedly elevated in 4 patients.
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PMID:[Continous ambulatory peritoneal dialysis (CAPD)]. 53 40

Our experience of CAPD in 21 patients over a total period of 118 patients months has been evaluated and compared with intermittent peritoneal dialysis (IPD). CAPD was associated with greater clearance of urea creatinine and phosphate, higher concentrations of haemoglobin, improved control of hypertension and saline overload, and better patient acceptance than IPD. It is concluded that CAPD is an effective form of dialysis with many advantages over IPD, although the incidence of peritonitis is still twice that IPD.
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PMID:Continuous ambulatory peritoneal dialysis (CAPD) in the treatment of end-stage renal failure. 54 78

The hemolytic-uremic syndrome consists of microangiopathic hemolytic anemia, acute renal failure, and thrombocytopenia following a prodromal illness of gastroenteritis or upper respiratory infection. The syndrome can present in dramatic fashion with severe abdominal pain and signs of peritonitis suggesting an acute surgical crisis. In a series of 25 patients, 40% had abdominal pain, 25% had abdominal tenderness, and 20% had peritoneal signs. Clues to diagnosis in the early stages of the acute illness were mild to moderate hypertension, abnormal peripheral blood smear, anemia despite dehydration, and proteinuria. Significant abdominal pain and x-ray evidence of colitis may occur before development of typical laboratory findings, and these were evident in at least one case. Three patients underwent laparotomy for suspected bowel perforation. Colitis without perforation was found in all cases. In the absence of documented perforation, toxic megacolon, or intussusception, the decision to perform laparotomy in patients with hemolytic-uremic syndrome who have signs of peritonitis must be individualized. Failure to recognize the underlying renal problem can lead to serious errors in fluid and electrolyte management and delay of appropriate therapy.
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PMID:Hemolytic-uremic syndrome: a diagnostic and therapeutic dilemma for the surgeon. 73 58

Twenty-one children with idiopathic nephrotic syndrome and minimal changes on renal biopsy were followed during all the disease. The average of follow-up was 37 months, with a range from 12 to 124 months. Recurrent proteinuria was the most important feature during the follow-up; 14 out of the patients showed frequent relapses, but only 2 patients showed major complication (peritonitis, septicemia) during relapses. Frequent relapses appeared most frequently in patients who began the disease before their fourth birthday, showed allergic history, had hypertension and red blood cells in urine, or had recurrent infections and finally, in those where proteinuria reappeared soon after prednisone therapy was ended. Prednisone alone was successful to induce remission, but it did not prevent frequent relapses. The association clorambucil-prednisone allowed lengthening of the period of remission and possibly for this reason the rate of relapses fell during the first 37 months of the follow-up. There are no signs which permit to predict the length of the disease and the frequent relapses can occur even after many years from the beginning of the disease. Special care of these patients avoids major complications.
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PMID:[Longitudinal study in children with the nephrotic syndrome and minimal glomerular lesion]. 75 27

An 8-year-old boy presented at UCLA Hospital with a one month history of hypertension prior to suffering a sudden onset of acute abdominal pain, rectal bleeding, peritonitis, and shock. Sigmoidoscopy showed diffuse mucosal friability. At laparotomy, inflammation and edema of the entire colon and terminal ileum were detected with two necrotic areas on the cecum. A 5 cm right adrenal pheochromocytoma with a hemorrhagic center was removed and a diverting loop ileostomy with inversion of the necrotic cecal areas was performed. Postoperatively, the blood pressure gradually returned to normal, and the colitis improved. Serum calcium and T3 T4 levels were normal. Review of the literature demonstrates that in patients with pheochromocytoma, progression from colitis to necrosis can be precipitated by a hypotensive episode. This patient suggests an example of catecholamine induced enterocolitis.
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PMID:Enterocolitis with peritonitis in a child with pheochromocytoma. 84 39

13 of 30 patients suffering from pseudo-LE-syndrome showed a usually reversible enlargement of the heart during the acute stage of the disease. In two patients carditis occurring in pseudo-LE-syndrome lead to congestive heart failure and an additional patient died in the acute stage of carditis. As opposed to Systemic Lupus Erythematosus hypertension did not occur in a higher frequency than normal. In five cases cardiac catheter examinations showed slight elevation of the end-diastolic pressure in the right ventricle, in two cases an abnormal high mean pressure in the right atrium and a systolic gradient at the pulmonic valve was found. -Scintigrams showed definite enlargement of the spleen and to a lesser degree enlargement of the liver was seen. Laparascopy showed multiple concretions after peritonitis. Lymphographic changes in the retroperitoneal lymph nodes and lymphatic ducts were not observed in contrast to rheumatic diseases. Drug histories in most cases discovered intake of Venopyronum dragees prior to onset of the disease. But recurrent attacks of the disease also occurred without further intake of the drug.
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PMID:[A contribution to the pseudo-LE-syndrome. Investigations of the cardiovascular system, abdominal organs, lymphatic system and drug histories (author's transl)]. 95 98

The culdoscopic procedure is a method of choice among surgical tubular sterilization techniques. It is a simple procedure but contraindicated in cardiac, pulmonary or renal insufficiency, diaphragmatic hernia, essential arterial hypertension, peritonitis and its precursors, vaginitis (cervitis), and diseases of the hip and knee. The latter conditions, especially, interfere with the knee-chest position used for the procedure. Asepsis in a surgical environment is required. Anesthesia consists of atropine premedication, meperidine and chlorpromazine iv, and a local anesthetic of novocaine injected into the posterior vaginal cul-de-sac and the median line. A special speculum is put in place; a bilateral fimbriectomy after exposure of the vaginal uterine tubes by the Douglas method is performed using Gutierrez-Najar forceps. The operation takes about 1/4 hour, and the patient may go home with her husband after about 6 hours of postoperative observation. The procedure is simple, rapid, and very useful and suited to developing countries. It leaves no scars but does reguire anesthesia. Among 100 such procedures performed from August 1973 to January 1974 in Saigon, there were virtually no complications. 94 of the patients were hospitalized for a full day or longer.
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PMID:[Culdoscopic sterilization]. 123 Apr 72

This patient was able to meet seven of the expected outcomes. Her weight and nutritional status improved after initiating CAPD, which she performed safely and effectively. She closely monitored her vital signs and appropriately notified the obstetrician when her blood pressure became elevated. She maintained proper fluid balance. The patient was successfully treated for exit site infection with antibiotics. She self-administered intraperitoneal antibiotics for peritonitis successfully. In spite of the infections, hypertension, and poor nutrition, the patient was able to complete her pregnancy to the 35th week and delivered a small, but healthy infant. Frequent monitoring and a team approach to S.B.'s well-being contributed greatly to her delivery of a viable infant. The education and training provided by the nephrology nurses was a key element in the successful management of the patient.
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PMID:Peritoneal dialysis patient completes successful pregnancy. 162 10


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