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Query: UMLS:C0020538 (hypertension)
 170,190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Normal standards for the blood pressure of rats under pentobarbital sodium anesthesia have been ascertained. Arterial hypertension did not consistently follow the injection of estradiol and pitressin in adult rats, and only transient hypertension occurred after the injection of dihydroxyphenylalanine. The injection of adrenalin in oil, however, was followed by cardiac hypertrophy, and it also resulted from (a) partial constriction of one renal artery, (b) the production of unilateral hydronephrosis, (c) traumatic injury to one kidney, (d) inducing unilateral perinephritis with a cellophane membrane. The blood pressure in many of the animals became elevated. In rats the weight of the heart is probably a more reliable index of the presence of the hypertensive state than is one measurement, or two, of blood pressure under anesthesia. The latter is extremely variable, both in normal and in hypertensive animals. Rats are, however, liable to hypertension under natural circumstances, and it can be easily induced in a number of ways. The weight of the heart may then become rapidly increased. To judge from the findings in this species, rats are very susceptible to the production of the hypertensive state, in comparison with other animals.
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PMID:ARTERIAL HYPERTENSION IN RATS : I. METHODS. 1987 Dec 2

These investigations are part of an attempt to study and interpret the intermediary metabolism of the kidneys in experimental renal hypertension. Hypertension was produced in dogs by the clamping procedure of Goldblatt and associates or by the silk perinephritis method of Page. Enzymatic studies were made by means of Warburg's manometric method. Cytochrome c was in addition determined spectrophotometrically. Tissue slices, homogenized tissue, and tissue extracts were used. A study of the cytochrome c concentration and the activities of the cytochrome oxidase and succinic dehydrogenase systems of kidneys from normal dogs and dogs with experimental renal hypertension was made. It was found that the cytochrome c concentration and the activities of the cytochrome oxidase and succinic dehydrogenase systems were markedly lower in the kidney slices and in the tissue suspensions from hypertensive dogs. Tissue suspensions and extracts of kidneys from hypertensive dogs showed an inhibitory effect on the activity of the cytochrome oxidase and succinic dehydrogenase, and the amine oxidase systems. Renin preparations also showed a marked inhibitory effect on the activities of cytochrome oxidase, succinic dehydrogenase, l-amino acid oxidase, and amine oxidase systems. A significant increase was found in the kidney of dogs whose other kidney had been removed or subjected to Goldblatt's or Page's technique in the activities of the cytochrome-cytochrome oxidase system, the succinic dehydrogenase system, and in the concentration of nucleotide-bound phosphorus, of flavin-adenine dinucleotide, and of the nicotinamide-adenine dinucleotides (coenzymes I and II). From the results of these studies it can be concluded that an increase in the concentration and activity of the respiratory enzymes precedes hypertrophy of the kidney. This can be explained by the assumption that an increase in the activity of the respiratory biocatalysts acts as a stimulus for cell growth and multiplication.
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PMID:THE METABOLISM OF THE KIDNEY IN EXPERIMENTAL RENAL HYPERTENSION : II. THE CONCENTRATION OF CYTOCHROME C AND THE ACTIVITIES OF THE CYTOCHROME OXIDASE AND OF THE SUCCINIC DEHYDROGENASE SYSTEMS IN THE KIDNEY OF DOGS WITH EXPERIMENTAL RENAL HYPERTENSION. THE INHIBITORY EFFECT OF RENIN AND OF KIDNEY TISSUE PREPARATIONS FROM HYPERTENSIVE DOGS ON THE RESPIRATORY ENZYMES. 1987 97

Page kidney was described by Page, following very elaborate experiments with animal kidneys in 1939, with persistent arterial hypertension from "cellophane perinephritis." Subsequently, it was reported after trauma, from renal cysts and tumors, and from intrarenal hematoma complicating percutaneous kidney biopsy. We describe Page kidney associated with acute kidney injury 26 days after an uncomplicated ultrasound-guided right native kidney biopsy. Patient was on Apixaban, a non-vitamin K antagonist oral anticoagulant (NOAC) for atrial fibrillation which was withheld 3 days before the procedure. It was restarted 3 days after. The evidence-base supporting guidelines and recommendations for the peri-procedural management of the NOACs is inadequate, sparse, and often conflicted. More research is warranted.
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PMID:Page Kidney Complicating Kidney Biopsy after Stopping Apixaban: A Physician's Dilemma. 3301 72


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