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Query: UMLS:C0020538 (hypertension)
 170,190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The second known case of a malignant catecholamine-secreting (DA)-secreting carotid body paraganglioma is presented. Dopamine synthesis and secretion can be increased in malignant tumors derived from neural crest cells. Whether this is true, in addition, for extra-adrenal paragangliomas is not yet clear. Malignant paragangliomas of the carotid body and larynx, although rare, frequently have been accompanied by increased catecholamine secretion. Malignant catecholamine-secreting carotid body paragangliomas are best treated by composite resection (internal carotid artery and neck dissection), with special attention being given to measures preventing severe hypertension and arrhythmias in the perioperative period.
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PMID:Malignant catecholamine-secreting carotid body paraganglioma. 641 Mar 37

A very rare case of paraganglioma of the bladder is reported. The patient was a 51-year-old man. He was admitted to our hospital on June 18th, 1981, with the complaint of gross hematuria. He had no attack of hypertension and we could not find in him any parasympathetic symptom except hematuria. Upon urological examination, he was suspected to have stage B cancer of bladder. He received partial cystectomy with uneventful course during the operation on June 30th, 1981 and was discharged on the 15th postoperative day. The postoperative histological diagnosis was paraganglioma of the urinary bladder. He was confirmed to have normal levels of catecholamine and its metabolites in the urine after 4 months postoperatively. At present, he is asymptomatic.
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PMID:[A case of paraganglioma of the urinary bladder]. 667 27

The coexistence of renal artery stenosis and pheochromocytoma has been recognized since 1958 and a total of 36 patients reported. This article provides an additional patient with an extra adrenal pheochromocytoma and fibrous bands constricting the left renal artery. Hypertension was confirmed to occur from both excess catecholamine production and hyperreninemia from the left kidney. Surgical removal of the functioning paraganglioma and correction of the renal artery stenosis restored the postoperative plasma catecholamine, renin, and blood pressure to normal. A literature review confirmed the coexistence of these two lesions but failed to provide a common etiology to explain the pathophysiology encountered. However, when the two diseases occur simultaneously, both must be diagnosed accurately and treated in a definitive manner.
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PMID:The coexistence of renal artery stenosis and pheochromocytoma. 683 Mar 55

A 27-year-old woman with an unusual combination of three independent tumors, gastric epithelioid leiomyosarcoma, retroperitoneal paraganglioma and pulmonary chondroma is reported. There are 15 similar cases collected by Carney (1979) from the literature; ours is the first Japanese case. Patients with this tumor triad tend to be young females, all were of blood group A. The prognosis of these patients is generally good without associated systemic hypertension. Our patient is well 18 months after surgical removal of the three tumors.
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PMID:[Case of three peculiar tumors of gastric epithelioid leiomyosarcoma, retroperitoneal paraganglioma and pulmonary chondroma]. 687 95

An unusual case of a functioning paraganglioma originating from the posterior mediastinum is reported. The main indications in the 21-year-old patient were hypertension and an abnormal roentgenogram of the chest. Blood and urine catecholamine assay confirmed the diagnosis of norepinephrine-secreting tumor, which was covered by the parietal pleura and attached to the sympathetic trunk. In the literature we could find reports of 25 patients with paraganglioma arising from the sympathetic trunk in the posterior mediastinum, 8 of whom had some symptoms and only 3 of whom were assayed for catecholamines. We diagnosed the present tumor as functioning aorticosympathetic paraganglioma according to the new classification and terminology suggested by Glenner and Grimley [1].
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PMID:Functioning paraganglioma in the posterior mediastinum. 708 89

A rare case of a paraganglioma (extraadrenal pheochromocytoma) that complicated both pregnancy and the puerperium is described. The patient presented a confusing clinical picture simulating pregnancy-induced hypertension, which, after delivery, masqueraded as intractable fever of unknown origin. Computed tomography precisely identified the presence and location of the mass, which had eluded detection despite exhaustive testing. Pheochromocytoma should be considered in the differential diagnosis of postpartum fever of unknown origin, especially if associated with paroxysmal hypertension.
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PMID:Paraganglioma complicating pregnancy and the puerperium. 708 20

Pheochromocytoma is a rare tumor of chromaffin tissue of the adrenal gland that synthesizes, stores and releases cathecolamines. In 10% of the patients it arises outside the adrenal gland, and has been called paraganglioma. The following study describes our experience in the diagnostic process and treatment of pheochromocytoma in two children, a 8-year-old boy with the right ureteral paraganglioma, and a 8-year-old girl with pheo-chromocytoma of the leftsuprarenal gland. Characteristic clinical features with predominant signs of hypertension, as well as the diagnostic flow diagram, have been presented. We have analysed recent diagnostic possibilities, sensitivity of diagnostic methods (ultrasonography, CT, selective angiography and J131 MIBG scintigraphy), indications for their use, and the importance of appropriate preoperative management. The major role of the J131-metaiodobenzilguanidine scintigraphy in diagnostic assessment, especially in precise preoperative localization and postoperative verification of tumour removal, has been stressed.
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PMID:[Modern diagnosis and treatment of pheochromocytoma in children]. 785 95

The clinical and endocrinological features in 106 patients (40 men, 66 women, mean age 48 +/- 14.3 years) treated between 1973 and 1993 for proven catecholamine-secreting tumours (phaeochromocytoma: n = 88, paraganglioma: n = 10, adrenal medullary hyperplasia: n = 8) were analysed. The most frequent symptoms were palpitations (68%), severe sweating (53%) and headache (42%). 10% of patients were symptom-free. 58% of patients had consistently raised blood pressure, and 20% of patients suffered paroxysmal blood pressure crises. However, 22% of patients did not have hypertension. Raised urinary catecholamines were found in more than 95% of cases; MIBG (metaiodobenzylguanidine) scintigrams were abnormal in more than 85% of cases. Patients with catecholamine-secreting tumours do not always have "classical" features. The high sensitivity of properly performed catecholamine measurement on plasma and urine has made dangerous stimulation and suppression tests obsolete.
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PMID:[Symptoms and endocrinologic features of catecholamine-secreting tumors. Results in 106 consecutive patients]. 800 63

Glomus jugulare tumors have been reported to secrete norepinephrine and cause severe hypertension with features similar to pheochromocytoma. In contrast, epinephrine secretion has not been observed in these neoplasms. This has been attributed to the absence of the norepinephrine-methylating enzyme, phenylethanolamine-N-methyltransferase (PNMT), required for epinephrine synthesis. We report a patient with severe hypertension caused by a glomus tumor that secreted norepinephrine and epinephrine. Following selective venous sampling, catecholamines were quantified by radioenzymatic assay. Marked elevations in norepinephrine and epinephrine release were localized to the glomus tumor. The enzymes involved in catecholamine biosynthesis, including PNMT and tyrosine hydroxylase, were identified immunocytochemically in the tumor. The glomus tumor had staining patterns identical to those observed within normal rat glomus cell. Hypertension resolved with resection of the functioning tumor. This is the first report of PNMT in a functioning paraganglioma of the glomus jugulare region. The factors that determine why functional activity is expressed only rarely by paraganglioma remain undefined.
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PMID:Hypertension and a tumor of the glomus jugulare region. Evidence for epinephrine biosynthesis. 813 4

Pheochromocytomas and functioning paragangliomas are rare tumors arising from indifferent cells of the primitive neural crest. These tumors produce clinical symptoms (pheochromocytoma syndrome) related to catecholamine production. The pheochromocytoma syndrome, constituted by arterial hypertension, headache and sweating, is due in 80% of cases to adrenal pheochromocytomas and only in 20% of cases is due to extra-adrenal secreting paragangliomas. The diffused localization of the Paraganglion System and the common embryologic origin, can explain the occasional identification of multicentric tumors (10%), and the association with multiple endocrine neoplasms (MEN), especially in familial occurrence. Careful follow-up of patients, in order to detect the later development of multicentric or metachronous neoplasms is necessary. The Authors present their experience with 80 patients affected by neoplasms involving the adrenal medulla and the multicentric paraganglion system, surgically treated during the last 25 years. Eight patients (10%) were affected by functioning extra-adrenal paragangliomas: 7 patients (87.5%) had solitary extra-adrenal tumors (6 abdominal and 1 thoracic) with a classic pheochromocytoma syndrome, and 1 patient (12.5%) had a double asymptomatic abdominal paraganglioma.
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PMID:[Functioning paraganglioma]. 817 42


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