Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020538 (hypertension)
 170,190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Three cases with paraganglioma of urinary bladder are described. All cases complained of palpitation, headache and paroxysmal hypertension after micturition. 131I metaiodobenzylguanidine scintigraphy successfully visualized the tumor of the bladder in all three cases.
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PMID:Paraganglioma of urinary bladder, visualization with 131I-MIBG scintigraphy. 361 64

To ascertain the magnetic resonance (MR) imaging characteristics of pheochromocytomas and paragangliomas and to compare MR with computed tomography (CT) and iodine-131 metaiodobenzylguanidine (I-131 MIBG), 19 patients (18 with pheochromocytomas, one with a paraganglioma) were studied. The 18 patients with pheochromocytomas had had positive findings with I-131 MIBG scintigraphy. Abdominal pheochromocytomas were generally hypointense compared with normal liver on T1-weighted MR images and extremely hyperintense on T2-weighted MR images. MR imaging was preferable to CT in the evaluation of primary pheochromocytomas due to superior tissue characterization, particularly in the patient with hypertension and borderline catecholamine levels. For patients with recurrent or metastatic disease, the data suggest that I-131 MIBG scintigraphy is the examination of choice.
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PMID:Pheochromocytoma and paraganglioma: comparison of MR imaging with CT and I-131 MIBG scintigraphy. 362 94

We report a 58 year old man suffering from recurrent epistaxis and high blood pressure. After removal of a subcutaneous tumour from the left neck the blood pressure and the pre-operatively elevated urinary excretion of adrenaline returned to normal. Histological examination of the tumour revealed a paraganglioma with immunocytochemical demonstration of serotonin.
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PMID:[Epistaxis, hypertension and neck tumor--a rare case of a hormonally active carotid paraganglioma]. 375 17

MR-tomography was employed for examination of 41 patients with arterial hypertension (AH). Aldosteroma was diagnosed in 11 patients, pheochromocytoma in 4 patients, paraganglioma in one patient. 25 patients with essential hypertension (EH) were entered into the comparison group and 16 healthy persons into the control group. Computerized tomography of the adrenals was performed in all the examinees. In MR-tomography normal adrenals were visualized as homogeneous formations of low intensity image surrounded by high intensity image of the retroperitoneal fat. In the patients with stage I-IIA EH adrenal shape and sizes did not differ from those in the control group. Certain enlargement and deformity of the adrenals were noted in the patients with stage IIB-III EH, especially in a malignant course of disease. Aldosteroma on MR-tomograms was visualized as an additional formation in the adrenal field, had a rounded or oval shape with regular clear contours; by intensity of image the tumor was similar to the liver. In the pheochromocytoma patients the tumor was also of a rounded shape, not always with clear borders, in one case with signs of the penetration in the vena cava inferior which was clearly visualized on the frontal sections. Paraganglioma found in one patients in the hilus of the left kidney, was of an oval shape with a high intensity signal, similar to that from the sympathetic chain. A study conducted in 3 reciprocally perpendicular planes clearly showed that the tumor adjoining the aorta was unconnected with the renal vessels.
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PMID:[Diagnostic possibilities of MR-tomography of the adrenals of patients with essential hypertension]. 382 72

An observation of the primarily multiple malignant paraganglioma of the urinary bladder and retroperitoneal space in combination with multiple uterine fibromyomas in a woman of 46 is described. Duration of the hypertension was 30 years. Hypertension crisis (up to 300/180 mm Hg) were usually associated with the urine discharge. Surgical removal of tumours was followed by a severe hypertension due to the catecholamine release into the circulation. Grimelius method confirmed the presence of endocrine granules in the cytoplasm of tumour cells. The role of chronic endocrine pathology in the evolution of extra-adrenal chromaffinomas and some questions of morphogenesis are discussed.
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PMID:[Multiple primary malignant paragangliomas of the bladder and retroperitoneal space]. 400 91

The Authors describe a case of artery hypertension caused by the secretion from the mediastinal paraganglioma and they emphasize the importance of correct diagnostic approach to patients with hypertension. This particular case is extremely rare, in literature, in fact, there are only 25 known cases of paraganglioma arising from the sympathetic trunk in the posterior mediastinum.
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PMID:[Arterial hypertension caused by mediastinal paraganglioma. Description of a case and review of the literature]. 406 86

Extraadrenal paragangliomas are tumors of the paraganglion system, usually arising from the carotid bodies, the glomus jugulare, or the glomus tympanicum. These tumors are capable of secreting catecholamines which can cause severe hypertensive crises. This paper reports a case of a patient who suffered a cerebral vascular accident due to hypertension resulting from a catecholamine-secreting infratemporal fossa paraganglioma. Any patient with a history of paroxysmal hypertension, headaches, and palpitations should be evaluated for a catecholamine-secreting tumor. Diagnosis and management of these tumors is best accomplished by a team including a radiologist, an endocrinologist, an anesthesiologist, a pathologist, an otolaryngologist--head and neck surgeon, and when the tumor invades the cranial cavity, a neurosurgeon. In this case, precise radiographic mapping of the tumor extent and its blood supply, control of hypertension with adrenergic blocking agents, and depletion of catecholamine stores using alpha-methyl-p-tyrosine allowed total extirpation through a craniofacial approach and a successful outcome.
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PMID:Catecholamine-secreting infratemporal fossa paraganglioma. 609 20

Two cases of sympathetic paraganglioma are reported: one, benign, in a 20-years old woman with arterial hypertension and attacks of excessive sweating; the other, malignant and with bone metastases, in a 44-years old woman. Both were diagnosed by scintigraphy, using meta-iodobenzylguanidine as radionuclide. This new radiopharmaceutic agent has recently been introduced for the detection of phaeochromocytomas, but it seems to be a general tissue marker of catecholamine uptake and storage. Its use as a therapeutic compound may also be envisaged.
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PMID:[Sympathetic paraganglioma. Scintigraphic detection using a new labeled molecule, meta-iodobenzylguanidine]. 623 75

A total of 44 carotid body tumors were observed for over 40 years at Memorial Sloan-Kettering Cancer Center in New York. The true nature of th paraganglioma can remain obscure in those patients without prior tissue biopsy or sophisticated diagnostic studies. Eighteen patients came to surgery without a primary working diagnosis of the conditions, 43 percent of the seris. Significant advances in the preoperative workup of a cervical mass attached to the carotid sheath are now recommended: ultrasonography, radioisotope perfusion scanning, and selective carotid arteriography. Catecholamine determination should be considered for any paraganglioma exhibiting vasomotor instability or hypertension. Prior to 1945 the carotid bifurcation was sacrificed eight times with a 50 percent mortality occurring in relatively youthful subjects. In the 35 years since then, a more sophisticated surgical technique preserving the carotid circulation has resulted in over 30 resections with but one fatality. Multicentricity, both in the sporadic and the familial form, is characteristic of this rare tumor, also called "APUDoma." (APUD is an acronym derived from three of the most important characteristics of these cells: a high amine content, amine precursor uptake, and decarboxylation. Its malignant potential is beyond debate.
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PMID:Carotid body tumors: a 40-year study. 625 Jun 80

In 1958 a mediastinal tumor was discovered in an asymptomatic patient. The tumor was resected and diagnosed as a nonchromaffin chemodectoma. Additionally an oesophageal abnormality was discovered but not treated. At subsequent follow-ups the mediastinum never appeared normal and the heart size progressively increased. In 1974 a small opacity appeared in the left lung. In 1975 the patient was operated: a pulmonary osteochondroma, a pericarditis and an intrapericardial aortopulmonary chemodectoma were discovered. The oesophagus was not explored. In july 1979 an inoperable epidermoid carcinoma of the main bronchus of the left lung was discovered and the patient died in september 1979. There was no hypertension and no catecholamine excess. A post-mortem section was refused. After the recent description by Carney of the triad: extra-adrenal paraganglioma, lung chondroma and gastro-intestinal leiomyo(sarco)ma, we feel that our patient could present this syndrome and that the oesophageal tumor could be a benign leiomyoma. However the exact diagnosis of the oesophageal lesion is still unknown.
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PMID:[The triad: mediastinal chemodectoma, chondroma of the lung and esophageal leiomyoma]. 632 47


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