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Obesity Surgery is not only capable to reduce body weight of the morbid obesity patients but also capable to treat complications such as Diabetes, Hypertension, Hyperlipemia and etc. From this point view, obesity surgery is recently called Metabolic Surgery, intending to treat Metabolic Syndrome. Gastric Bypass, Adjustable Gastric Banding, Vertical Banded Gastroplasty, and Biliopancreatic Diversion are widely recommended in the world. We have operated 97 cases of morbid obesity patients with various types of gastric bypass and gastroplasty since 1982. Laparoscopic surgery is induced in the field of obesity surgery around 1995, and since then, it has been exploring rapidly over the world. Two thirds of total cases are recently operated laparoscopicaly in the world. We adopted laparoscopic obesity surgery in 2000, and now several institutions are operating with laparoscopy even in Japan. Considering the characteristic features of Japanese obese, we should have our own guideline for obesity surgery. Patients who have BMI > or =35 and severe complications which need to be treated promptly should be applied to surgical treatment in Japan.
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PMID:[Current status of obesity surgery as metabolic surgery]. 1714 94

In recent years, bariatric surgery has become an increasingly used therapeutic option for morbid obesity. The effect of weight loss after bariatric surgery on the predicted risk of coronary heart disease (CHD) has not previously been studied. We evaluated baseline (preoperative) and follow-up (postoperative) body mass index, CHD risk factors, and Framingham risk scores (FRSs) for 109 consecutive patients with morbid obesity who lost weight after laparoscopic Roux-en-Y gastric bypass surgery. Charts were abstracted using a case-report form by a reviewer blinded to the FRS results. The study included 82 women (75%) and 27 men (25%) (mean age 46 +/- 10 years). Mean body mass index values at baseline and follow-up were 49 +/- 8 and 36 +/- 8 kg/m(2), respectively (p <0.0001). During an average follow-up of 17 months, diabetes, hypertension, and dyslipidemia resolved or improved after weight loss. Thus, the risks of CHD as predicted by FRS decreased by 39% in men and 25% in women. The predicted 10-year CHD risks at baseline and follow-up were 6 +/- 5% and 4 +/- 3%, respectively (p < or =0.0001). For those without CHD, men compared favorably with the age-matched general population, with a final 10-year risk of 5 +/- 4% versus an expected risk of 11 +/- 6% (p <0.0001). Likewise, women achieved a level below the age-adjusted expected 10-year risk of the general population, with a final risk of 3 +/- 3% versus 6 +/- 4% (p <0.0001). In conclusion, weight loss results in a significant decrease in FRS 10-year predicted CHD risk. Bariatric surgery decreases CHD risk to rates lower than the age- and gender-adjusted estimates for the general population. These data suggest substantial and sustained weight loss after bariatric surgery may be a powerful intervention to decrease future rates of myocardial infarction and death in the morbidly obese.
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PMID:Reduction in predicted coronary heart disease risk after substantial weight reduction after bariatric surgery. 1722 22

Morbid obesity is a worldwide pandemic. Medical problems associated with being obese include hypertension, diabetes, pulmonary restrictive disease, obstructive sleep apnea, and increased risk of cancer. In addition, there is a tremendous financial burden on society and the health care system to take care of these individuals. Bariatric surgery has proved to be a safe, effective means of sustained weight loss, which can lead to improvement or resolution of obesity-related medical conditions. Individuals who are morbidly obese represent a unique population requiring special consideration when presenting for medical care.
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PMID:Obesity and considerations in the bariatric surgery patient. 1743 Jul 67

Nonalcoholic fatty liver disease (NAFLD) is an emerging clinical entity. There is limited data on NAFLD from India. The objective of this article was to review all the published literature on NAFLD from India. The epidemiological studies including prevalence ofNAFLD amongst special groups like in those with unexplained rise in transaminases, diabetes mellitus and cryptogenic cirrhosis, studies on pathogenesis including insulin resistance, iron abnormalities, and studies available for the treatment of such patients have been reviewed. In addition some of the differences between Indian patients and those from the West have been highlighted. Available literature show that majority of Indian patients with NAFLD have overweight or obesity as per Asian Pacific criteria even though they do not have the kind of morbid obesity as seen in patients from the West. Other differences between Indian patients and those from the West include less of metabolic syndrome including its components like diabetes mellitus and hypertension, less of iron abnormalities and HFE gene mutations and mild histological disease at presentation in Indian patients. More data is required to substantiate these findings and to prove if NAFLD patients in India are different at presentation.
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PMID:Nonalcoholic fatty liver disease in India--is it different? 1754 90

Surgery is usually the only solution to modify the evolution of morbid obesity and resolve the associated co-morbidities. There is very little written regarding malabsorptive surgery and transplantation. A 48-year-old male with hypertension, hyperuricemia and obesity underwent renal transplantation in 1994 for renal amyloidosis. He was maintained on oral immunosuppressive cyclosporine. The patient developed uncontrollable hypertension, hyperlipemia, hyperglycemia and increasing weight to a BMI of 44. Thus, in December 2004, he underwent biliopancreatic diversion (BPD). After 18 months follow-up, he has lost 85% of his excess weight, and his hypertension, hyperglycemia and hyperlipemia are markedly improved. Renal function was not modified, nor were the levels of cyclosporine. He has had no complications derived from the BPD, and has a better quality of life.
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PMID:Biliopancreatic diversion in a renal transplant patient. 1760 72

From October 1988 to March 2005, there were at least 92 autopsy cases where morbid obesity was present and/or where it was attributed to the cause of death in the coronial district of Auckland, New Zealand, a city with a population of over 1 million people. Obesity has been researched internationally, and much is known about associated comorbidities such as atherosclerotic disease, hypertension, and diabetes, to name a few. However, in the morbidly obese (body mass index>or=40 kg/m2), only 14 of 92 cases were found to have ischemic heart disease due to coronary atherosclerosis as the principal cause of death, and slightly over half (48/92) have some degree (mild, moderate, severe) of coronary atheroma. There is a strong positive correlation between heart weight and body weight. Only 8 livers were normal, all others showing some form of steatosis, venous congestion, and fibrosis/cirrhosis. The mean weights of the heart, lungs, and liver were above the normal reference range in almost all cases. In conclusion, the study did not follow the widely published finding of the positive correlation between morbid obesity and ischemic heart disease in terms of mortality, but the study was consistent with other studies on the organ manifestations of morbid obesity, particularly for the heart, lungs, and liver.
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PMID:Polysarcia adiposa: morbid obesity. 1772 Nov 78

We evaluated the relationship between seven personality disorders listed in the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders and coronary heart disease (CHD) in a nationally representative sample of U.S. older adults. We analyzed data on 10,573 adults aged 60 or older from the National Epidemiologic Survey on Alcohol and Related Conditions. In our results, we found that 13.30% of older adults reported a diagnosis of CHD confirmed by a health professional. Age (odds ratio or OR = 1.04), morbid obesity (OR = 1.59), hypertension (OR = 2.30), nicotine dependence (OR = 1.39), any drug use disorder (OR = 2.13), and any mood disorder (OR = 1.87) increased the odds of having CHD. Female gender (OR = 0.72) and social drinking (OR = 0.71) decreased the odds of having CHD. Controlling for these variables, we found that avoidant (OR = 1.80), schizoid (OR = 1.63), and obsessive-compulsive (OR = 1.37) personality disorders increased the odds of having CHD. Personality disorders may increase the risk of CHD in older adults. Putative mechanisms and directions for future research are proposed.
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PMID:DSM-IV personality disorders and coronary heart disease in older adults: results from The National Epidemiologic Survey on Alcohol And Related Conditions. 1790 71

The prevalence of obesity in children and adolescents has increased dramatically in the past 3 decades. Childhood and adolescent obesity are associated with serious comorbidities including type 2 diabetes mellitus, hyperlipidemia, and hypertension. Most obese children and adolescents have no defined underlying endocrine or genetic syndrome. Evaluation of an obese child or adolescent involves a detailed personal and family history, physical examination, and selected laboratory evaluation. Lifestyle interventions and behavioral modification aimed at decreasing caloric intake and increasing caloric expenditure are essential to management of childhood and adolescent obesity. Surgical approaches have a role in management of morbid obesity and serious obesity-related comorbidities in adolescents. Further research is needed to evaluate the role of various dietary approaches and pharmacotherapy in the treatment of obesity in childhood and adolescence.
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PMID:Evaluation and management of childhood and adolescent obesity. 1790 31

The incidence of obesity worldwide has increased markedly in the past 2 decades, with estimates of increases of 50% in the United States alone. Research indicates that weight loss produced by diet alone is not sustained and that 75% of dieters regain most of the weight lost within 1 year and 90% within 2 years. Morbid obesity is associated with comorbid conditions, including heart disease, hypertension, diabetes, mechanical arthropathy, sleep apnea, and numerous other serious disorders and a shortened life expectancy. Because of limited success with medical management, surgical treatment of morbid obesity has been used increasingly, especially with the development of laparoscopic procedures, including Roux-en-Y gastric bypass (RYGB). RYGB is associated with low surgical mortality, marked decreased food intake, and significant, sustained weight loss. However, in this emerging, unique population there is growing appreciation that these procedures may be associated with the development of bone loss and skeletal fragility because of altered nutrient metabolism. Despite the threat of skeletal fragility and fracture, there is limited data addressing the effects of bariatric surgery on bone metabolism and bone loss.
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PMID:Bone loss. An emerging problem following obesity surgery. 1792 86

The radiologic tables used for many imaging procedures have maximum weight limits. Many United States (US) adults may have a body weight that exceeds these limits and may be ineligible for diagnostic imaging procedures. Using data from the National Health and Nutrition Examination Surveys in 1976 to 1980, 1988 to 1994, and 1999 to 2004, we determined the increase in the percentage and number of US adults weighing>or=300 pounds (i.e., the weight limit for an electron beam computed tomography table). In addition, the prevalence and clustering of 5 cardiovascular disease risk factors (current smoking, hypertension, diabetes mellitus, low high-density lipoprotein cholesterol, and elevated C-reactive protein) was determined for US adults weighing>or=300 pounds, and compared with their counterparts weighing<300 pounds. The percentage of US adults, >or=20 years, weighing>or=300 pounds was 0.10%, 0.79%, and 1.50% in 1976 to 1980, 1988 to 1994, and 1999 to 2004, respectively (p trend<0.001). This corresponds to an increase from 130,000 US adults weighing>or=300 pounds in 1976 to 1980, to 1,390,000 in 1988 to 1994 and 3,020,000 in 1999 to 2004 (p trend<0.001). After age standardization, in 1999 to 2004, 34.1% and 24.0% of adults weighing>or=300 pounds had 2 and >or=3, respectively, of the 5 cardiovascular disease risk factors, compared with 17.7% and 5.3%, respectively, of adults weighing<300 pounds (each p<0.001). In conclusion, morbid obesity has increased dramatically among US adults. The clustering of cardiovascular disease risk factors associated with morbid obesity and the exclusion from diagnostic imaging may affect those most in need of such procedures.
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PMID:Comparison of percent of United States adults weighing>or=300 pounds (136 kilograms) in three time periods and comparison of five atherosclerotic risk factors for those weighing>or=300 pounds to those<300 pounds. 1803 63


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