Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020538 (hypertension)
 170,190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A symptomatic renal cyst causing pain, hypertension, or obstruction requires surgery. A new endourological method as alternative to an open surgical procedure is presented. The renal cyst is punctured percutaneously under ultrasound guidance. The channel is dilated under radiological control, the cyst is then inspected endoscopically with the flexible endoscope and the cyst wall is resected. The technique is presented and the results in the first 5 patients are discussed.
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PMID:[Percutaneous surgery of kidney cysts]. 639 30

Cerebellar hemangioblastomas are known to be occasionally associated with abdominal tumors such as renal cyst and renal cell carcinoma. But most of the abdominal tumors reported are clinically silent and usually diagnosed after the hemangioblastomas have been found in the central nervous system. We report a rare case in which a renal cell carcinoma preceeded in its onset of symptoms 4 years to a cerebellar hemangioblastoma. A 56-year-old female underwent left nephrectomy because of a left renal cell carcinoma at the age of 49. About 4 years after the nephrectomy, she developed signs and symptoms of intracranial hypertension and was operated on for a cerebellar tumor which was histologically diagnosed as hemangioblastoma. Her family history was non-contributory. Four years later, recurrence of the cerebellar tumor was found on the CT scan and abdominal studies were negative except for a suspected parapelvic cyst in the right kidney on abdominal ultrasonography. Subtotal removal of the cerebellar hemangioblastoma was performed followed by irradiation.
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PMID:[Cerebellar hemangioblastoma developing after nephrectomy for renal cell carcinoma]. 654 70

A case of a left simple renal cyst associated with hypertension is presented. Preoperative renin was elevated on the left renal vein. Hypertension disappeared after evacuation of the cyst. The possibility of renovascular hypertension in association with the cyst is considered.
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PMID:Resolution of hypertension after retroperitoneal removal of a solitary renal cyst. 663 72

Two half-brothers with tuberous sclerosis (TS) presented with polycystic kidneys in early childhood, before the classical stigmata became apparent. Their father shows no evidence of the disease. The older boys subsequently developed adenoma sebaceum at nine years and the younger boy developed infantile spasms. Hypertension occurred in both cases but neither showed evidence of renal failure. Extensive renal cyst formation in TS is rare, but when it does occur it differs from both infantile and adult-type polycystic disease. TS should be considered in the differential diagnosis of renal enlargement, haematuria and hypertension in childhood.
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PMID:Two half-siblings with tuberous sclerosis, polycystic kidneys and hypertension. 685 88

The diagnostic and predictive value of renal venous renin determinations was investigated in 73 patients who had various forms of hypertension associated with unilateral renal disease and who were operated upon. Patients with fibromuscular hyperplasia showed a markedly higher cure rate than cases with arteriosclerotic renal artery stenosis (64% vs. 25%) and were less frequently not improved (4% vs. 12%). Patients with unilateral (non-vascular) small kidney and patients with unilateral hydronephrosis showed comparable high cure rates (53% and 50%, respectively), whereas in no patient with a unilateral renal cyst did postoperative blood pressure return to normal. In the present study no statistically significant correlation was found between postoperative pressure reduction and PRA-ratios in either the whole group of patients or in the various subgroups. A negative PRA-ratio (less than or equal to 1.4) was found in 36% of all cured patients. In particular, cured patients with fibromuscular hyperplasia showed a high percentage (38%) of falsely negative tests. As expected, characteristic differences were observed in simple clinical data between cured and improved patients. Patients with normal postoperative blood pressure were significantly young (34.7 +/- 13.6 years) than improved cases (47.3 +/- 10.8 years; P less than 0.001) and cured patients showed lower preoperative blood pressure values (192 +/- 29/119 +/- 15) than improved ones (214 +/- 31/126 +/-117 mm Hg). Thus our results document a limited prognostic value of renal venous renin determination in patients with hypertension due to unilateral renal disease.
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PMID:Renal venous renin activity in various forms of curable renal hypertension. 701 75

In patients with solitary renal cysts and only borderline hypertension for the exclusion of a connection a clarification by side-separated renin determination of the renal veins has been recommended (6). This investigation would finally clarify whether the affected kidney is responsible for the hypertension. However, this somewhat cumberous diagnostics is reserved for larger clinics. It is astonishing that in literature is scacely or not at all referred to the double diagnostic possibility of the puncture of the renal cyst: apart from the exclusion of malignity by cytologic investigation of the fluid and contrast representation of the cystic cavity a decrease of blood pressure after this relatively small intervention might refer to the necessity of further diagnostics. When at the same time a hypertension exists in punctures of the renal cysts one should therefore always use careful measurings of blood pressure before and after puncture, in order possibly to gain a valuable reference to a connection between the solitary renal cyst and the hypertension.
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PMID:[Blood pressure observation during renal cyst decompression--case report on a benign solitary renal cyst as a cause of hypertension]. 741 92

The amount of proteinuria is a prognostic indicator in a variety of glomerular disorders. To examine the importance of urinary protein excretion in autosomal dominant polycystic kidney disease, this study determined the clinical characteristics of autosomal dominant polycystic kidney disease patients with established proteinuria and the frequency of microalbuminuria in hypertensive autosomal dominant polycystic kidney disease patients without proteinuria. In 270 autosomal dominant polycystic kidney disease patients, mean 24-h urinary protein excretion was 259 +/- 22 mg/day. Forty-eight of 270 autosomal dominant poly-cystic kidney disease patients had over proteinuria (> 300 mg/day). The patients with established proteinuria had higher mean arterial pressures, larger renal volumes, and lower creatinine clearances than did their nonproteinuric counterparts (all P < 0.0001), a greater pack year smoking history (P < 0.05), and the projection of a more aggressive course of renal disease (P < 0.05). All autosomal dominant polycystic kidney disease patients with established proteinuria were hypertensive, as compared with 67% without established proteinuria (P < 0.001). Forty-nine patients with hypertension and left ventricular hypertrophy without established proteinuria were examined for microalbuminuria; 41% demonstrated microalbuminuria. Those with microalbuminuria had higher mean arterial pressure, larger renal volumes and increased filtration fraction. Therefore, established proteinuria and microalbuminuria in autosomal dominant polycystic kidney disease patients are associated with increased mean arterial pressure and more severe renal cystic involvement.
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PMID:Overt proteinuria and microalbuminuria in autosomal dominant polycystic kidney disease. 789 1

Acquired cystic kidney disease occurs in over 74% of patients with ESRD on hemodialysis for more than 4 yr. A variety of complications have been associated with these cysts including bleeding, lithiasis, infection, obstruction, and malignant transformation. An ESRD patient who developed accelerating hypertension secondary to an acute perinephric hematoma due to a bleeding-acquired renal cyst is described. The hypertension, which was refractory to aggressive drug therapy, was controlled only after the involved kidney was removed, after the demonstration of an elevated ipsilateral renal vein renin level. This is the first case reported in which worsening hypertension, apparently due to the "Page Kidney," developed as a complication of perinephric bleeding in an ESRD patient with acquired cystic kidney disease.
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PMID:Uncontrolled hypertension and hyperreninemia after hemorrhage in a patient with end-stage renal disease and acquired renal cysts. 794 80

We reviewed the records of 132 children with persistent hypertension who were evaluated by our pediatric nephrology services between 1987 and 1991. Eighty-nine (67%) of these children were found to have renal or renovascular disease, 30 (23%) had primary hypertension and 13 (10%) had a non-renal cause for their hypertension. Glomerulonephritis (n = 37) and reflux nephropathy (n = 26) were the most frequent renal disorders identified. Renal artery thrombosis was the most common cause of hypertension in the neonatal period (in 6 of 12 neonates, 50%) whereas cystic kidney disease was the most common cause of hypertension in the 1st year of life (in 9 of 30 infants, 30%). The prevalence of primary hypertension increased with age; this diagnosis was made in 16 of 46 (35%) hypertensive patients between 12 and 18 years of age and, more surprisingly, in 8 of 27 (30%) children between 7 and 11 years of age. These data confirm that secondary hypertension is the most common cause of hypertension in children but suggest that primary hypertension is more prevalent than previously recognized in patients between 7 and 18 years of age.
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PMID:Etiology of sustained hypertension in children in the southwestern United States. 801 97

The simple renal cyst (SRC) is a common entity even though its actual incidence is difficult to determine given that it tends to manifest itself in an asymptomatic fashion. Occasionally, cases of SRC with clinical manifestations have been described in the literature, such as arterial hypertension (AHT) and biological alterations such as hematuria or proteinuria. The purpose of this article is to find the prevalence of AHT, proteinuria, and hematuria in patients with SRC detected via echography. 1,197 echographs that explored the renal area--a number equal to that of the number of patients--were reviewed. In 66% of the cases, the echographs were taken for some purpose unrelated to renal pathology. For those who presented SRC, blood pressure, proteinuria per 24 hours, and urine sediment were determined. SRC was detected in 93 patients (7.7%). The prevalence of AHT in patients with SRC was 31%, but 57% of those were older than 85 years. Two patients presented AHT and proteinuria; both fulfilled the criteria for nephrongiosclerosis. Two other patients presented hematuria and proteinuria; one was found to be afflicted with IgA nephropathy and the other with vesical carcinoma. A patient with hematuria was a carrier of renal lithiasis. We conclude that the prevalence of AHT in patients with SRC did not yield a significantly different result from that of the general population. In those patients who presented proteinuria and/or hematuria, one cause was found to be responsible; therefore, the presence of such alterations in patients with SRC should be considered coincidental.
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PMID:[Prevalence of arterial hypertension, proteinuria and hematuria in patients with simple renal cyst]. 829 Jul 56


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