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 170,190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Ischemic cardiopathies in Eastern Africans at Djibouti are frequent: 2.9 % of the in patients and 73 % of the cardiac diseases. Male prevalence is marked. Coronary insufficiency is most often demonstrated by the usual symptomatology. Three groups of electrocardiopathic manifestations have been individualised: ischemia proving angor (288 cases), anginose syndromes revealing a myocardic infarct (81 cases), acute myocardic infarcts (62 cases). The patients come for the most part from Djibouti and belong to any social class. The part played by a food mainly constituted of complex glucids, refined sugar and lipids is pointed out. Arterial hypertension, diabetes, essential hypercholesterolemia and tobacco intoxication are the most frequent risk factors. This coronary pathology is closer the one met with in the Near East than ischemic cardiopathies observed in tropical Africa which begin to emerge.
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PMID:[Ischemic cardiopathies in Africans in Djibouti. Study of 431 cases in 5 years]. 58 Sep 20

A prospective study was conducted from March 1972 to November 1976 in a group of Kaunas male population ranging in age from 45 to 59 years. At the beginning of the study it consisted of 3,553 individuals. They were divided into groups of low, moderate, and high risk according to the presence of a risk factor (hypertension, hypercholesteremia, impaired glucose tolerance test) and a pathologic condition. The ratio of the total mortality rate per 1,000 of the population during the observation period in these groups was 1 : 2 : 3, while that of the mortality of ischemic heart disease was 1 : 3 : 5. The rate of out-patient coronary mortality and the occurrence of new cases with myocardial infraction according to their number registered in the groups of low, moderate, and high risk was 1 : 2 : 5. All the indices in the group of individuals who refused to take part in the study were close to those in the high risk group. The data obtained point to the possibility of defecting by means of preventive study individuals exposed to a greater or lesser risk of the development of ischemic heart disease and death, which makes it possible for the Public Health Service to concentrate attention of definite groups of the population so as to apply differentiated preventive measures.
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PMID:[Division of the 45- to 59-year-old male population into groups depending on the risk factors in a prophylactic study of ischemic heart disease]. 59 8

The method of selecting population groups with risk factors for applying measures of primary prevention of ischemic heart disease among males 40 to 49 years of age is discussed. The article shows the results of two-stage screening conducted among 18,707 males born between 1922 and 1931 for the selection of volunteers with relatively stable risk factors of ischemic heart disease: arterial hypertension (systolic pressure 160 mm Hg or higher and/or diastolic pressure 96 mm Hg or higher) and hypercholesterolemia (above 260 mg percent). The data of the experimental preventive study show a lack of willingness among the population to take part in preventive measures aimed at controlling ischemic heart disease. When conducting preventive measures among the unorganized population, most attention should be focused on the organization of the primary screening examination, i.e. the first contact of the population with the physician.
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PMID:[Selection of groups of the male population 40 to 49 with risk factors for conducting primary prophylaxis of ischemic heart disease]. 59 33

In 500 obese patients (146 men, mean age 37 +/- 13 years, Broca index 147 +/- 24; 354 women, mean age 36 +/- 14 years, Broca index 151 +/- 28) cardiovascular risk factors (RF) were investigated. The most frequent RF was hypertension (71 per cent), followed by glucose intolerance (49 per cent), hypertriglyceridemia (31 per cent), hypercholesterolemia (22 per cent) and hyperuricemia (22 per cent). Only 12 per cent of the patients were without RF. These patients were younger and less obese than the patients with RF. The prevalence of RF increased with increasing age and overweight. Analysis revealed significant correlations between overweight and blood pressure, blood glucose, insulin and age. Significant correlations between age and hypertension, blood glucose cholesterol, triglycerides and overweight were detected. The correlation between overweight and the sum of all RF was higher (r = 0.35) than the one between age and the sum of all (r = 0.23). Obese patients had a high prevalence of RF. Increasing overweight and (to a lesser extent) age are both associated with increased prevalence of RF. On the basis of the prevalence of RF, patients with gross obesity (Broca index greater than around 150) were considered to be at a high risk in respect of coronary heart disease.
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PMID:Cardiovascular risk factors in gross obesity. 61 33

Electron microscopic evidence of early atherogenic changes in the aorta and coronary arteries was obtained in normal fed, conscious, unrestrained rats receiving electrical stimulation in the lateral hypothalamus for periods of up to 62 days. Hypertension and hypercholesterolemia were not etiologic factors. In view of recent observations concerning neuropsychological mechanisms in human ischemic heart disease, the findings raise the possibility that the human central nervous system has a role in the development of atherosclerotic lesions.
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PMID:Neural factors contribute to atherogenesis. 61 68

An association of coronary artery occlusion, as determined by coronary arteriography with age, prevalence of risk factors and alcohol intake was studied in 1635 male and 371 female heart patients. The degree of coronary artery occlusion was positively related to elevated cholesterol, elevated triglycerides, diabetes, age and history of smoking for both male and female patients. Hypertension was related to the degree of occlusion only for female patients. Male and female patients who had a higher alcohol intake tended to have less extensive occlusion. No positive association was found between obesity and the degree of occlusion. When the patients were divided on the basis of age (less than 50 and greater than or equal to 50 years) the findings did not differ. The lack of finding a relation between obesity and occlusion or between hypertension and occlusion for males differs from the general findings of epidemiologic studies on the relation between these risk factors and coronary heart disease. The authors believe that this discrepancy may either be explained by the way they selected patients (i.e., they selected patients who underwent a diagnostic angiographic examination), or that obesity and hypertension are not directly related to coronary occlusion but influence occlusive disease through some secondary mechanism.
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PMID:Risk factors and angiographically determined coronary occlusion. 62 92

515 women and 372 men from a rural community of 2862 inhabitants over 14 years volunteered to participate in a screening test for risk factors. We found an exceptionally high percentage of hypertension and hypercholesterolaemia as well as overweight. Women were more frequently affected than men except for smoking, which occurred 3,6 times more often in men than in women. Since the life expectancy of men in this community was clearly lower than that of women, smoking seems to have the most weight as a risk factor for cardiovascular diseases.
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PMID:[Results of screening for risk factors in a rural community (author's transl)]. 64 59

Myocardial infarction remains one of the leading causes of mortality and morbidity in spite of the medical and surgical therapy currently available. Only the prevention of coronary atherosclerosis seems likely to modify this situation. Epidemiological studies have established hypertension, hypercholesterolemia and cigarette smoking, among others, as risk factors. Based on these findings, it was hypothesized that control of these factors might diminish the risk. This hypothesis has been tested in man repeatedly over the past twenty years. Except as regards cigarette smoking, the results of the studies are ambiguous. Before advising the general public on measures of prevention, more data on the etiology of atherosclerosis are needed.
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PMID:[Prevention of myocardial infarct?]. 64 71

In 1.035 persons with reduced glucose tolerance (borderline diabetics, diabetic biophan G test admissions, spontaneous admissions and diabetics treated already for a longer time) the cardiovascular factors of risk over-weight (Broca-weight greater than or equal to 110%), hypertension (RR greater than or equal to 160/and/or 95 Torr), hypertriglyceridaemia (greater than or equal to 200 mg/100 ml), hypercholesterolaemia (greater than or equal to 300 mg/100 ml) and hyperuricaemia (greater than or equal to 6.5 mg/100 ml in males and 6.0 mg/100 ml in females) were determined and compared with the frequency of the same danger indicators of 255 persons with certainly normal glucose tolerance. Taking into consiteration the reduction of the glucose tolerance as cardiovascular factor of risk the glucosuria test admissions with 3.48 factor of risk/proband had no less factors of risk than the spontaneous diabetic admissions (3.29 factor of risk/proband). Already the borderline diabetic differed in the frequency of overweight, hypertension and hypertriglyceridaemia significantly (p less than 0.01) from the normal case of the same age. Thus the glucose tolerance disturbed in its limit deserves increased consideration from the diabetological as well as from the cardiological point of view.
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PMID:[The cardiovascular risk profile of subjects with normal, marginally disordered and proven pathological glucose tolerance]. 64 41

The relationship between age, biomedical risk factors and the progression of occlusive disease of the coronary arteries was studied in 176 patients (age range, 27-66 years) who had undergone at least two cine angiograms. The biomedical risk factors of interest were serum concentrations of cholesterol and triglycerides, smoking, hypertension, diabetes mellitus, family history of coronary disease, electrocardiographic abnormalities, obesity, and age. The findings did not reveal any significant differences in mean lipid levels between patients showing progression of disease and those who did not. However, the distribution of serum cholesterol values indicated more hypercholesterolemic patients among the disease-progression group, and more patients with ideal cholesterol levels among the no-progression group. The other biomedical variables did not appear to be related to the progression of coronary disease. Among the older patients, hypercholesterolemia and diabetes mellitus were related to disease progression. Among the younger patients, smoking was related to progression.
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PMID:Relationship of age and biomedical risk factors to progression of coronary artery disease. 65 67


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