Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0020538 (hypertension)
 170,190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The value of health screening among the general population has been well-documented, with testing for hypertension, diabetes, and glaucoma now commonplace. It was the purpose of our study to determine the efficacy of a screening program for peripheral vascular disease and carotid artery disease using the noninvasive laboratory diagnostic tools. In the screening for peripheral disease, there were 496 participants with a mean age of 35 (range 17 to 63) years. All participants had an ankle:brachial index (ABI) of 0.95 or greater except one (0.47). Risk factors included smoking (350), history of cardiac disease (19), family history of vascular disease (204), and pain in the legs on walking (39). The risk factors could not be correlated with any objective vascular findings (abnormal ABIs). A Doppler ultrasound device, including an inflatable ankle cuff, was used to measure the ABI of the dorsalis pedis and posterior tibial vessels. Testing was performed on a volunteer basis after the participant completed a check-off sheet of risk factors. In screening for carotid artery disease 1338 women, whose average age was 31 years, had an less than 1% incidence of cardiac disease, and 803 men, whose average age was 40 years, had a 4% incidence. Less than 1% of the group had diabetes mellitus. All patients were asymptomatic referable to the extra-cranial vascular system. Two men of the 2141 persons tested had a lesion meriting further evaluation. The role of Health Fairs may be more effective as an educational resource than a diagnostic interventional tool.(ABSTRACT TRUNCATED AT 250 WORDS)
 ...
PMID:Is screening for vascular disease a valuable proposition? 328 41

The composition of the clientele from an ophthalmological practitioner's office is described with special reference to the occurrence of glaucoma and disc haemorrhages (h in singular; hh in plural). This study could not be planned as an epidemiological survey and gives no clue to sensitivity or specificity of hh in glaucoma. During a period of about 10 years ending with 1986 there were 731 patients with h and/or glaucoma. When detected, 185 patients had h but no glaucoma, 33 had both h and glaucoma and 513 had glaucoma but no h. During the follow-up period hh were detected in 83 cases of glaucoma, and glaucoma developed in 27 cases with hh. The detection rate of hh among glaucoma was low but steady, indicating that hh may occur at any stage of the glaucoma process. This study shows no predilection for hh in cases with general hypertension or diabetes, nor is the frequency of hh among pseudoexfoliation cases significantly lower than among cases without this stigma.
 ...
PMID:Disc haemorrhages and glaucoma in a general ophthalmic practice. 338 91

Ninety-four individuals with well-documented glaucomatous visual field loss were matched by age, race, and sex to 94 controls. Both groups completed a detailed interview about past and current ocular and systemic diseases. We also ascertained medication, alcohol, and cigarette use. Blood pressure measurements were taken at the time of the interview. Diabetes showed the closest association with glaucoma [odds ratio, 2.80 (1.01,7.77]). A history of hypertension and/or medication use was not associated with glaucoma, but elevated diastolic blood pressure showed some association [odds ratio, 2.40 (0.85,6.81]). Separate analyses for whites and blacks showed diabetes to be a risk factor for both groups. Diastolic blood pressure and alcohol use appeared to be more strongly associated with glaucoma among whites, but these results should be cautiously interpreted because of the small numbers available for subgroup analysis.
 ...
PMID:Risk factors for primary open angle glaucoma. 339 91

A comparison between results obtained by pattern electroretinography (ERG), Ganzfeld cone and rod-ERG was made in 7 patients suffering from melanoma, glaucoma and retinal detachment. It was shown that the extent of the lesions, not seen ophthalmoscopically, can be well monitored by the second harmonic component of pattern electroretinography in cases where conventional Ganzfeld ERG's do not reveal defects. Especially damage caused by acute glaucoma attacks and those stemming from chronic hypertension can be well differentiated.
 ...
PMID:Clinical applications of pattern electroretinography: melanoma, retinal detachment and glaucoma. 340 17

The incidence of acute intraoperative suprachoroidal hemorrhage (AISH) was studied in 2,839 consecutive extracapsular cataract extraction cases operated by nucleus expression and phacoemulsification. Twenty-five eyes (0.9%) were identified with this complication. Acute intraoperative suprachoroidal hemorrhage was defined as the acute accumulation of fluid in the suprachoroidal space which resulted from a presumed suprachoroidal hemorrhage at the time of surgery. Preoperative risk factors for the development of this complication included advanced age and the presence of glaucoma. Sex, controlled hypertension, long axial length, and method of cataract removal could not be identified as significant risk factors. Recognition of the early signs of AISH and initiation of rapid wound closure followed by the completion of secondary operations performed the next day helped to meet the surgical objective and to provide excellent visual results, with 21 eyes (84%) having a visual acuity of 20/30 or better.
 ...
PMID:Acute intraoperative suprachoroidal hemorrhage in extracapsular cataract surgery. 349 Dec 6

Chronic and recurrent choroidal (ciliochoroidal) detachments developed following glaucoma filtration surgery in 14 eyes of 13 patients during a 9-year period. Three specific subgroups were identified: recurrent, inflammatory, and chronic (present for more than 6 months). The factors that may be related to the development of chronic and recurrent choroidal detachments included patient age (mean, 68.8 years), systemic hypertension or atherosclerotic heart disease, hyperopia, aqueous suppressant therapy, ocular inflammation, and full-thickness filtration surgery. A total of 46 choroidal detachments in 14 eyes were recorded and required drainage of suprachoroidal fluid on 34 occasions. All eyes developed visually significant cataracts, and complete resolution of the recurrent or chronic choroidal detachment occurred following cataract extraction in six eyes. Treatment of chronic and recurrent choroidal detachments should include intense therapy of ocular inflammation, discontinuation of medications that can incite ocular inflammation, discontinuation of topical and systemic aqueous suppressant therapy, and when a visually significant cataract is present, cataract extraction combined with a choroidal tap should be performed.
 ...
PMID:Chronic and recurrent choroidal detachment after glaucoma filtering surgery. 357 81

In a previous paper we reported an elevated incidence of systemic illnesses in a population of 846 cataract patients. The charts were reviewed to determine the prevalence of systemic illnesses and of drug allergy. Elevated rates of hypertension (46.0%), diabetes mellitus (15.8%), glaucoma (11.0%) and drug allergy (30.6%) were found. Recommendations are made for preoperative assessment of cataract patients.
 ...
PMID:Systemic illnesses in cataract patients: 2. Prevalence. 359 6

Thirty-two acute hypertensive unilateral, non granulomatous uveitis were clinically and functionally examined to try to determine the pathogenic factors of the occurrence of intraocular hypertension. The witness group included an equal number of acute non-hypertensive, non-granulomatous and unilateral uveitis cases, with a clinical aspect and etiology similar to the first group. The determination of the coefficient of outflow facility to the patients with hypertensive unilateral uveitis emphasized pathological values in 93.7% of the eyes with uveal inflammation and in 56.2% of the fellow eyes. Gonioscopy in the fellow eyes disclosed a narrow indocorneal angle in 90.6% of the cases. Corroboration of fellow eyes, all the examinations of the emphasized 4 had history cases of simple glaucoma (of which 2 had a familial of primitive glaucoma) and 6 cases of suspicious glaucoma (of which 4 had a familial history of primitive glaucoma). The patients with non-hypertensive unilateral uveitis presented normal values of the outflow facility in the two eyes. Clinically and functionally their fellow eyes were normal. Taking into account the statistically significant difference between the mean age of uveitis with and without hypertension, it is concluded that advanced age represents indirectly a factor of hypertension in uveitis, because, since, it diminishes the degree of opening of the camerular angle and as well, it reduces the outflow facility and increases the frequency of occurrence of simple and suspicious glaucomas.
 ...
PMID:[Factors determining the occurrence of intraocular hypertension in uveitis]. 361 10

Most of the estimated 40 million blind individuals in the world are in the older age groups. Data on blindness and visual impairment are primarily from blindness registries and prevalence surveys in different countries throughout the world. The quality of these data vary tremendously from one country to another, and comparability of the results from different studies is difficult. However, all studies indicate an increase in the prevalence of visual loss and blindness with increasing age. Cataract is the most prevalent eye disease in the world and is a major cause of visual loss in developing as well as in developed countries. Other major eye diseases in the elderly include age related macular degeneration, glaucoma, and diabetic retinopathy. A number of risk factors have been suggested for cataract, age related macular degeneration, and glaucoma, yet few have been well established. Certain factors for these conditions are similar, including age, hypertension, prolonged exposure to sunlight, and nutritional factors such as Vitamin E. Epidemiologic studies are needed to define the risk factors for these different eye diseases with the goal of decreasing risk of disease and possible disease prevention, as well as developing better estimates of the magnitude of the problems of visual loss and eye diseases in the elderly.
 ...
PMID:Epidemiology of eye disease in the elderly. 365 39

Sixty-eight foreign-born Hispanic patients with angiography-proven retinal-vein occlusion (RVO) and 50 age-, sex-, and race-matched controls were evaluated for systemic disease. Thirty of the RVO patients had central retinal-vein occlusion, and 38 had branch retinal-vein occlusion. Hypertension, the most commonly associated factor, was present in 66.2% of the RVO patients in contrast to 18% of the controls (P less than .001). Other factors which were more common in the RVO population included open-angle glaucoma (19.1% vs 8%), diabetes mellitus (16.2% vs 12%), and atherosclerotic heart disease (14.7% vs 10%); these, however, were not statistically significant (P greater than .05). Hyperlipidemia was present in 12% of the controls and 10.3% of the RVO group (P greater than .50). This is in direct contrast to reports of nonHispanic populations where hyperlipidemia has been reported to be present in up to 60% of RVO patients.
 ...
PMID:Factors associated with retinal-vein occlusion in Hispanics. 366 15


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>