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Query: UMLS:C0020538 (hypertension)
 170,190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The purpose of this study was to test the effects of a low-fat, low-cholesterol diet on serum lipids, platelet aggregation, thromboxane formation and blood pressure. Fifteen hyperlipidemic males with normal blood pressure were treated for 2 weeks. Resting supine blood pressure, total serum cholesterol, HDL-cholesterol, the ratio of total cholesterol/HDL-cholesterol and triglycerides all were significantly reduced. The maximum aggregation and velocity of aggregation for isolated platelets stimulated with either ADP or collagen was significantly reduced. Thromboxane formation during 5 min of platelet aggregation with collagen or ADP was also significantly reduced. These results have important implications for hypertension and atherosclerotic cardiovascular disease.
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PMID:Effects of a low-fat, low-cholesterol diet on serum lipids, platelet aggregation and thromboxane formation. 347 54

A case of anaerobic sepsis associated with Fusobacterium mortiferum is reported. Blood cultures from a 60-year-old man with type II diabetes mellitus, hypertension, severe atherosclerotic cardiovascular disease, and renal insufficiency revealed on a gramstained smear highly pleomorphic gram-negative bacilli with bizarre forms and round bodies. Growth of the organism on nonselective anaerobic media and analysis of its pattern produced results characteristic of Fusobacterium mortiferum.
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PMID:Anaerobic septicemia secondary to Fusobacterium mortiferum. 371 72

Evidence from animal and human studies indicate that calcium supplementation may ameliorate two risk factors for atherosclerotic cardiovascular disease, hypertension and hyperlipidemia. We sought to characterize dietary fat consumption and plasma lipid profiles in hypertensive and normotensive subjects and plasma lipid responses to supplemental calcium. A randomized, double-blind, placebo-controlled, crossover protocol was used to assess blood pressure and lipid response to 8 wk of 1000 mg of elemental calcium in 43 hypertensive and 27 normotensive subjects. Nutrient intakes and plasma lipids were measured repeatedly. Hypertensive female subjects consumed significantly less (p less than 0.05) phosphorus, potassium, and magnesium and had significantly higher triglycerides (p less than 0.04) and lower HDL-cholesterol (p less than 0.02) than did normotensive subjects. There were no significant changes in dietary plasma lipids with calcium supplementation. Mildly hyperlipidemic normotensive subjects had a significant decrease in total cholesterol (p less than 0.05). No significant changes in plasma lipids occurred with calcium supplementation in hypertensive subjects.
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PMID:Plasma lipids and hypertension: response to calcium supplementation. 379 5

Because controversy exists regarding continued use of the seated position for neurosurgical procedures, this prospective (1981-1983) and retrospective (1972-1981) analysis of 554 seated patients was done to establish the incidence and severity of venous air embolism (VAE) related to type of surgical procedure and anesthetic technique; to examine the impact of specific monitoring practices on detection, morbidity, and mortality; and to establish the incidence of other complications related to the seated position (hypotension, quadriplegia, and arterial air embolism (AAE)). The overall morbidity and mortality related to the seated position was 1% (2 VAE, 1 AAE, 2 hypotension, 1 myocardial infarction) and 0.9% (1 VAE, 1 AAE, 2 hypotension, 1 quadriplegia), respectively. There has been no mortality since 1975. N2O did not seem to increase the incidence or severity of VAE. The seated position is safe in experienced hands if appropriate surgical and anesthetic skills are exercised in patient selection and management. Caution is advised in patients with atherosclerotic cardiovascular disease, severe hypertension, cervical stenosis, and right to left intracardiac shunts.
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PMID:Anesthesia and surgery in the seated position: analysis of 554 cases. 406 24

Disease processes affecting the aorta are gaining increasing attention as average longevity of the population in this country increases and as awareness of conditions such as hypertension and atherosclerotic cardiovascular disease improves. Aortic dissection is commonly seen as a manifestation of these processes in the aging population and is the most common catastrophic illness affecting the aorta. Familiarity with its pathogenesis, diagnosis, and therapy is mandatory to prevent almost certain death if left untreated.
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PMID:Acute aortic dissection. 407 Nov 78

To learn more about the prognosis of young patients with atherosclerotic cardiovascular disease we reviewed our experience with patients 40 years of age or younger who required surgical intervention for cardiovascular occlusive disease. We identified 47 patients, 25 of whom required peripheral vascular reconstruction and 22 of whom underwent coronary artery bypass grafting. All but one patient were extremely heavy cigarette smokers. Of the 11 women with peripheral vascular disease, eight required operations for limb salvage and three for renovascular hypertension. Four of the 11 women required a total of 11 subsequent operations because of recurrent or progressive disease. Of the 14 men, 13 required intervention for limb salvage and one for renovascular hypertension. Forty-five additional operations, including 15 amputations, were required in these 14 male patients because of recurrent or progressive disease. Of the 22 patients (21 men and one woman) who underwent coronary artery bypass operations, there was one postoperative death. Five patients (23.8%) required a second bypass operation and one patient (4.8%) required a third procedure bypass because of recurrent symptoms and occluded grafts. One patient has occluded grafts and inoperable disease. Atherosclerotic cardiovascular disease in young patients appears to be a virulent disease process and is associated with a high rate of recurrent or progressive disease. There is a striking association between the premature development of atherosclerotic cardiovascular disease and cigarette smoking.
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PMID:Atherosclerosis in the young: a virulent disease. 633 32

We evaluated 935 patients for risk factors of cholecystectomy. Factors assessed included reason for cholecystectomy, preoperative laboratory values, sex, age, weight, presence of associated disease, and pathologic findings. Evaluation revealed an overall significant complication rate of 10.50% and a mortality of 1.07%. Risk factors were age over 60 years, hypertension, atherosclerotic cardiovascular disease with prior heart failure, and acute cholecystitis. Incidental cholecystectomy was associated with an increased risk due to concomitant associated disease. Patients with obesity and uncomplicated diabetes had the same risk as the general population.
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PMID:Risk factors for cholecystectomy: analysis of 935 patients. 661 88

Risk for renal insufficiency (RI) resulting from nonsteroidal anti-inflammatory drugs (NSAID) exists in cirrhosis with ascites, nephrotic syndrome, decompensated congestive heart failure, and chronic renal disease. We saw seven cases of NSAID RI that demonstrate important additional clinical risk factors. These include advanced age (mean, 76 years), use of diuretic drugs (6/7 patients), and evidence of renal vascular disease as suggested by long-standing hypertension, diabetes, or atherosclerotic cardiovascular disease (7/7 patients). Analysis of past case reports of NSAID RI also showed these features. Treatment of acute gouty arthritis was the most common precipitating event. Evolving NSAID RI was suggested by rising serum urea nitrogen, serum creatinine, and serum potassium levels, and body weight gain associated with low fractional excretion of sodium. We conclude that since NSAID RI is preventable and reversible, it is important to recognize and monitor the conditions of those patients at risk.
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PMID:Identification of risk for renal insufficiency from nonsteroidal anti-inflammatory drugs. 686 44

This chapter reviews the evidence from epidemiologic studies and controlled clinical trials dealing with dietary fats and blood pressure. Trials studying the effect on blood pressure of n-3 polyunsaturated fatty acids from fish oil show a dose-response hypotensive effect that may be restricted to patients with atherosclerotic cardiovascular disease. However, fish oil is not a practical therapy for hypertension given the large dose required (10 capsules per day) for a small effect (3-4 mmHg). From numerous studies, it is clear that saturated and n-6 polyunsaturated fats have no effect on blood pressure. Monounsaturated fats also have no effect but fewer studies have examined this relation.
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PMID:Dietary fats and blood pressure. 761 13

Hypertension predisposes to all the major atherosclerotic cardiovascular disease outcomes, with coronary heart disease (CHD) the most common and lethal sequela. Hypertension is only one of many risk factors for CHD and is variably hazardous, depending on the number and severity of co-existent, metabolically linked risk factors. Importantly, about half the CHD events occur in hypertensive patients in the upper quartile of multivariate risk. An epidemiologist can recognize differences in hypertensive candidates for cardiovascular disease based on their cardiovascular risk profile rather than relying solely on the character of the blood pressure elevation. Once a composite risk profile for hypertensive patients has been established, at-risk individuals can be more readily identified, allowing treatment to be more appropriately targeted to improve the multivariate cardiovascular risk profile whilst reducing the blood pressure. Such an approach provides maximum benefit and cost effectiveness.
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PMID:An epidemiological perspective in hypertension problem solving. 774 39


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