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Query: UMLS:C0020538 (hypertension)
 170,190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

2 cases of serious complications from oral contraception are presented. The first patient, on oral contraception for some time, died of a temporal hernia due to severe intracranial hypertension. Autopsy and angiography revealed thrombosis of the venous sinuses. The second patient, on oral contraception for 20 months, developed sudden aphasia and epilepsy without ever losing consciousness; tests showed intracranial hypertension, but a normal angiography. She recovered rapidly after treatment and after suspension of oral contraception. Oral contraceptives might alter the mechanism of production and reabsorption of cerebrospinal fluid, and also disturb the hypothalamo-hypophyseal function. The article includes a short review of studies on the problem.
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PMID:[Benign intracranial hypertension and thrombosis of the venous sinuses during contraceptive treatment: anatomo-clinical and neuroradiological observations (author's transl)]. 9 25

A disease characterized by edema, proteinuria, hypoproteinemia and hypertension was seen in late gestation in patas monkeys. The initial sign was edema of the perineum, ankles and lower trunk. The onset was abrupt, occurring 7 days or less prepartum. The affected animals were not depressed, and convulsions were not seen. In 6 of the 98 pregnancies during a 1-year period, symptoms of the disease were present. The highest incidence was manifested by primiparous animals with 3 of 36 pregnancies affected. Two of 38 second pregnancies and 1 of 24 third pregnancies were also affected. Five of the animals recovered spontaneously and were normal 14 days postpartum. Edema persisted for 30 days in one female. This animal continued to be hypertensive and had persistent mild proteinuria and hypoproteinemia. She was killed approximately 1 year postpartum due to severe renal disease. The spontaneous disease seen in patas monkeys resembled toxemia of pregnancy in humans more closely than the experimentally induced disease in other animals.
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PMID:Spontaneous preeclamptic toxemia of pregnancy in the patas monkey (Erythrocebus patas). 10 69

A case of 17-hydroxylase deficiency in a 14 years old girl is reported. She presented with the unique association of hypertension, hypokaliemia, delayed puberty and growth failure. It is suggested that the reduced statural growth starting between 7 and 10 years of age and accompanied by a markedly reduced bone maturation was, at least in part, the consequence of the absence of adrenarche. The secretion rate of cortisol was very low while an increased production of D.O.C. and corticosterone was demonstrated by the elevated levels of their urinary tetrahydroderivatives. A good feminisation and a growth spurt were observed under ethinyl oestradiol substitutive therapy. A progressive normalization of the kaliemia and the blood pressure was obtained with hydrocortisone treatment but long term hydrocortisone therapy appears less satisfactory with easy clinical manifestations of overdosage on the one hand and incomplete maintenance of normal blood pressure of the other hand.
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PMID:[The deficiency of 17-hydroxylase: a cause of growth and puberty retardation in the girl. One case]. 30 59

A 59-year-old woman was admitted to the hospital for evaluation of her hypertension. She was treated with hydralazine; two days later a severe acute hepatitis supervened. On discontinuation of the agent, the liver damage disappeared, relapsed during inadvertent rechallenge, and healed following permanent withdrawal from the drug. Histologic study of the liver showed severe acute hepatitis with bridging necrosis (so-called subacute hepatitis). Six months after discontinuation of hydralazine, a second liver biopsy specimen showed a complete remission of the disease. This hydralazine-induced hepatitis appears to be fully reversible and to differ both on clinical and histological grounds from two previous reports documenting a granulomatous liver disease.
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PMID:Acute hepatitis with bridging necrosis due to hydralazine intake. Report of a case. 44 77

A 63-year-old black woman, admitted to Charity Hospital, New Orleans, for treatment of hypertension and congestive heart failure, was found clinically and histopathologically to have Hansen's disease. She had lived most of her life in Orleans Parish and had no known contact as a source of her infection.
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PMID:A case of leprosy at Charity Hospital, New Orleans. 45 68

A 17-year-old woman manifested fever, abdominal pain, headache, and hypertension caused by a solitary, benign pheochromocytoma. She also had hypercalcemia and elevated plasma immunoreactive calcitonin levels. After removal of the pheochromocytoma, calcium and calcitonin levels returned to normal. Studies of peripheral and tumor venous blood showed no excess or ectopic parathyroid hormone secretion, but the tumor contained and secreted calcitonin. Sporadic pheochromocytoma may secrete calcitonin and cause hypercalcemia by non-parathyroid hormone-mediated mechanisms. The potential is clearly present for confusion with multiple endocrine neoplasia, type 2 (medullary thyroid carcinoma, pheochromocytoma, and primary hyperparathyroidism).
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PMID:Pheochromocytoma associated with hypercalcemia and ectopic secretion of calcitonin. 46 64

A girl aged 1 year 9 months ingested a single tablet of 0.3 mg of clonidine. She became soon drowsy and unconscious with bradycardia and severe hypotension. Bradycardia was antagonized promptly by atropine, and blood pressure was corrected by giving intravenous fluids. The level of consciousness fluctuated for 6 to 8 hr from alertness to unconsciousness. Serum concentrations of clonidine were only about two times higher than the mean therapeutic values in adults in the treatment of hypertension. Thus small doses of clonidine seem to be potentially dangerous for small children.
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PMID:Severe poisoning in a child caused by a small dose of clonidine. 46 78

A 46 year old woman who used oral contraceptives (OCs) for 10 years developed severe arteriosclerosis of the base of the brain and renally fixed hypertension. She subsequently died of cerebral hemorrhage. The relationship between o.c. use and hypertension is discussed. A thorough family and personal anamnesis must be taken for women who want to use o.c.s; hypertension, kidney ailments, obesity, or diabetes mellitus require particular attention. Blood pressure should be checked for the first 3 months of o.c. use and every 6 months thereafter. Weight gain during o.c. use may serve as a warning symptom. Hypertension or several other difficulties require discontinuation of o.c. use to determine whether they may be caused by o.c.s.
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PMID:[The problem of hypertension and ovulation inhibitors]. 47 16

This paper reports the case of a girl who, at the age of 7 years, presented with a saccular aneurysm of a brachial artery. Over the following 8 years a further 15 aneurysm appeared, involving limb and visceral arteries and the aorta. Some, but not all, of these aneurysms have been operated upon. Complications included renovascular hypertension due to bilateral intrarenal aneurysms. She had been followed up for 15 years. Three other similar cases have been found in the medical literature, and these are also referred to. In two of these cases the affected persons also exhibited some of the other connective tissue anomalies associated with the Ehlers--Danlos syndrome. These were not present in our patient. The relationship between the syndrome of multiple congenital aneurysms and the Ehlers--Danlos syndrome is discussed.
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PMID:Multiple congenital aneurysms in childhood: report of a case. 66 48

A 20 year old woman with tetralogy of Fallot and an associated atrial septal defect presented with severe hypertension and congestive heart failure. She had been acyanotic for several years. An acute trial of antihypertensive therapy during cardiac catheterization resulted in severe systemic oxygen desaturation and loss of consciousness. Since surgical correction, antihypertensive therapy has been well tolerated. This case demonstrates the hemodynamic importance of systemic vascular resistance in tetralogy of Fallot and the need for extreme caution if aggressive antihypertensive therapy is attempted before surgical correction.
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PMID:Systemic hypertension complicating tetralogy of Fallot: effects of antihypertensive therapy. 68 43


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