Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0020505 (hyperphagia)
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Human Gene/Protein
ARNT2 protein 12.3
Aryl hydrocarbon receptor nuclear translocator 2 12.3
OR7G3 11.3
Proprotein convertase subtilisin/kexin type 1 11.3
OR7E24 10.8
kinase suppressor of ras 2 10.8
ZNF274 10.2
G protein-coupled receptor 83 10.0
FAM102A 10.0
PWCR 10.0
G6F 10.0
KRAP 9.8
C2orf34 9.8
Zfp69 9.8
MAGEL2 9.6
brain mitochondrial carrier protein-1 9.3
QRFP receptor 9.3
SH2B2 9.3
HACL1 9.2
PREPL 9.1
MYO1D 9.0
POPDC3 9.0
SNTG2 9.0
MONA 8.9
SIM1 8.8
melanocortin-4 receptor 8.8
FGARAT 8.8
peroxisome proliferative activated receptor gamma 8.8
LIM domain only 4 8.6
melanocortin 4 receptor 8.6
retinoic acid induced 1 8.5
DNAJC27 8.5
doublecortin kinase-2 8.5
HEN2 8.5
Prolyl endopeptidase-like 8.4
GCP5 8.4
OR7D4 8.4
QRFP 8.3
TTC21B 8.3
POLE2 8.3
PCSK1 8.2
ZRANB1 8.2
agouti 8.2
Y5 receptor 8.1
small-conductance calcium-activated potassium channel 8.1
bombesin receptor subtype-3 8.0
Synphilin-1 8.0
PWS 8.0
ob protein 8.0
ubiquitin-protein ligase E3A 8.0
NIPA2 8.0
BRS-3 7.9
SH2B1 7.9
melanocortin receptor 7.9
MFAP4 7.9
MBOAT7 7.9
Sra-1 7.9
DGK-zeta 7.9
Proopiomelanocortin 7.9
NPY2R 7.9
epithelial membrane protein 1 7.8
GPR7 7.8
MKRN3 7.8
IL6 protein 7.8
Growth hormone secretagogue receptor 7.8
GPR8 7.7
proopiomelanocortin 7.7
Insulin receptor substrate 2 7.7
insulin receptor precursor 7.7
MC4R 7.7
PXDN 7.6
p15 protein 7.6
MCHR1 7.6
leptin receptor 7.6
ANKRD26 7.6
type III adenylyl cyclase 7.6
5-HT-1A 7.6
Citrin 7.6
MC3 7.6
CHRNA6 7.5
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Disease
hyperphagia 12.3
Winter Depression 12.3
Acute appendicitis with perforation 11.3
unable to stop eating 11.3
Hypothalamic obesity 10.8
Hyperganglionosis 10.8
Extreme immaturity 10.8
Acute gastric mucosal lesion 10.8
Atypical anorexia nervosa 10.8
Sudden acquired retinal degeneration 10.8
appetite disorder 10.6
compulsive overeating 10.4
Hyperphosphaturia 10.3
Psychosocial dwarfism 10.3
Axillary vein thrombosis 10.3
Kleine-Levin syndrome 10.1
Phagophobia 10.0
Atypical depression 9.9
chronic chorea 9.8
Subclavian vein thrombosis 9.6
Substance-related disorders 9.5
Chronic pulmonary embolism 9.3
hydropneumopericardium 9.3
Lipoatrophic diabetes 9.3
Cushing's ulcer 9.3
Hypothalamic dysfunction 9.3
Gastric necrosis 9.3
Kluver-Bucy syndrome 9.2
Gallbladder sludge 9.2
Food hoarding 9.1
Self-induced vomiting 9.1
Gastric dilatation 9.0
Candida endophthalmitis 8.9
MONA 8.9
pyopneumopericardium 8.9
hypersexuality 8.8
Fungal endophthalmitis 8.6
hypothalamic disorder 8.6
Neuronal intestinal dysplasia 8.5
Candida sepsis 8.4
binge eating 8.3
Candida osteomyelitis 8.3
Alstrom syndrome 8.1
partial trisomy 14q 8.0
Hypophagia 8.0
moderate obesity 7.9
pituitary chromophobe adenoma 7.8
pig-bel 7.8
scalp dermatitis 7.8
bulimia nervosa 7.8
Ampulla of Vater 7.6
Superior mesenteric artery syndrome 7.6
Hypervigilance 7.5
unable to remember 7.5
nonorganic psychosis 7.5
dysbasia 7.5
Imu 7.3
Latent autoimmune diabetes in adults 7.3
Pancreatic ascites 7.3
Biliary sludge 7.3
overnutrition 7.2
Cronkhite-Canada syndrome 7.2
Disuse atrophy 7.2
CTLN2 7.2
eating disorder 7.2
Necrolytic migratory erythema 7.1
calorie deficiency 7.1
head-banging 7.1
cholangiolitis 7.1
metabolic syndrome X 7.1
ARH 7.1
Acute acalculous cholecystitis 7.0
Pulmonary Langerhans cell histiocytosis 7.0
Progressive Aphasia 7.0
MKKS 7.0
Acute renal insufficiency 7.0
morbid obesity 6.9
Azotemia 6.9
FXTAS 6.8
Hyperamylasemia 6.8
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Symptom
Hyposexuality 9.5
polydipsia 8.8
hypersomnia 8.7
aphagia 8.3
Mucosal hyperplasia 8.1
polyuria 7.8
hunger 7.7
Osler's nodes 7.6
adipsia 7.4
Pain and tenderness 7.3
Roth spots 7.1
corpulence 7.1
stomach distension 7.0
hypotonia 6.6
phosphatemia 6.6
eye discharge 6.3
Skin symptoms 6.2
overweight 6.1
anorexia 6.0
hypoproteinemia 5.9
emaciation 5.9
dysosmia 5.8
feeling depressed 5.8
ketonuria 5.8
Cushingoid 5.6
thirsty 5.6
infant diarrhea 5.6
inanition 5.5
Cushingoid 5.5
hyperemesis 5.1
cachexia 5.0
physical exhaustion 5.0
Catch 4.9
hyperemesis gravidarum 4.8
loss of taste 4.8
lethargy 4.8
decreased appetite 4.7
apathy 4.7
leg edema 4.5
auditory hallucination 4.3
Psychiatric symptoms 4.0
starvation 4.0
vomiting 3.9
sleepiness 3.9
prostration 3.8
hopelessness 3.7
insomnia 3.7
abdominal fullness 3.7
consciousness disturbance 3.7
hypertonia 3.6
bloating 3.6
hypothermia 3.6
bitter taste 3.5
tenesmus 3.4
stomach pain 3.4
nipple discharge 3.3
hyperesthesia 3.3
POA 3.3
Decreased activity 3.3
enuresis 3.2
nipple discharge 3.2
personality change 3.2
abdominal discomfort 3.2
excessive sweating 3.2
memory loss 3.1
Fluctuation 3.1
fatigue 3.0
acute stress 3.0
Depressive symptoms 3.0
forgetfulness 2.9
right upper quadrant pain 2.9
diarrhea 2.9
heartburn 2.9
hepatomegaly 2.8
physical appearance 2.8
colic 2.7
intestinal bleeding 2.7
ophthalmoplegia 2.6
abdominal pain 2.6
Wind 2.6
more...
Drug
Terramycin ophthalmic 11.3
Periactin 8.9
Metreleptin 8.0
Armodafinil 8.0
Potassium carbonate 7.8
Butorphanol tartrate 7.6
Zaltoprofen 7.6
Brofaromine 7.5
Sodium propionate 7.4
Dexfenfluramine 7.4
Namenda 7.2
Teduglutide 7.2
CMNX 7.0
Calcium gluconate 6.8
Penfluridol 6.7
Lantus 6.6
Monosodium glutamate 6.6
Enprostil 6.4
LMOX 6.3
Anafranil 6.3
Amoxapine 6.3
Naprosyn 6.1
Modafinil 6.1
Ciglitazone 6.1
Rimonabant 6.0
Humulin 6.0
Sandostatin LAR 5.9
7-Nitroindazole 5.9
Insulin detemir 5.9
Sulpiride 5.7
Coconut oil 5.7
Sodium acetate 5.7
Anafranil 5.6
Liraglutide 5.6
Trilostane 5.6
CMX 5.6
Liposyn 5.5
Mazindol 5.5
Morphine sulfate 5.5
Corn oil 5.1
Soybean oil 5.1
CET 5.0
Ritanserin 4.8
Agomelatine 4.8
Kollidon 4.8
GHRP 4.8
RAL 4.4
AmBisome 4.3
PPA 4.1
Sandostatin 4.1
Sandostatin 4.1
Serum albumin 4.1
Mirtazapine 4.1
Dexon 4.0
Colombo 4.0
Ritalin 4.0
Coumadin 3.9
Growth hormone 3.9
Tao 3.8
Zonisamide 3.8
Growth hormone 3.6
Diurnal 3.6
Ramipril 3.6
Glucagon 3.5
Dihydro 3.3
Orphan 3.3
DHT 3.2
Streptokinase 3.2
9-THC 3.2
CED 3.2
DHT 3.2
linolenate 3.1
Portal 3.1
Vitamin B12 3.1
Fluconazole 3.0
Triad 2.9
Everolimus 2.9
Cimetidine 2.7
Cimetidine 2.7
DBS 2.6
more...
Enzyme
proprotein convertase 1 6.8
TSO 6.1
fatty-acid synthase 6.1
CDP-diacylglycerol synthase 5.7
BAT 5.5
oligopeptidase B 5.4
AMP-activated kinase 4.5
phenol hydroxylase 4.5
BIS 4.4
O-GlcNAc transferase 4.4
11beta-hydroxysteroid dehydrogenase 4.3
glucokinase 4.3
hormone-sensitive lipase 4.3
lipoprotein lipase 4.2
acetyl-CoA carboxylase 4.2
diacylglycerol acyltransferase 4.1
glycerophosphate acyltransferase 4.1
3-hydroxyacyl-CoA dehydrogenase 3.9
DTA 3.9
ACAT 3.8
fructokinase 3.8
AMP-activated protein kinase 3.8
3-hydroxy-3-methylglutaryl-CoA reductase 3.8
prolyl endopeptidase 3.7
carboxypeptidase E 3.7
phosphoenolpyruvate carboxykinase 3.6
phosphoenolpyruvate carboxykinase 3.6
CPN 3.6
glucose-6-phosphatase 3.6
LPL 3.5
phosphoenolpyruvate carboxykinase 3.5
acyl-CoA oxidase 3.4
DOPA decarboxylase 3.3
isopeptidase 3.2
AMPK 3.2
tryptophan hydroxylase 3.1
p-nitrophenylphosphatase 3.1
monoamine oxidase 3.0
PDH 2.9
monoacylglycerol lipase 2.9
cholesterol acyltransferase 2.9
argininosuccinate synthetase 2.9
fatty acid desaturase 2.9
alpha-glucosidase 2.9
3-hydroxy-3-methylglutaryl coenzyme A reductase 2.8
glycerol kinase 2.8
DAT 2.8
pyruvate kinase 2.8
chalcone synthase 2.8
SST 2.8
acyl-CoA dehydrogenase 2.7
GABA transaminase 2.7
PAT 2.6
ornithine transcarbamylase 2.6
sucrase-isomaltase 2.6
glycerol-3-phosphate dehydrogenase 2.6
ALDH 2.5
asparaginase 2.5
glycerol-3-phosphate dehydrogenase 2.5
Pla 2.5
cytochrome oxidase 2.4
CYP7A1 2.4
ALA synthase 2.3
hexokinase 2.3
furin 2.3
proprotein convertase 2.2
aldose reductase 2.2
ADH 2.2
AMPK 2.2
CPT 2.2
sucrase 2.1
IKK 2.1
CPS 2.0
tyrosine aminotransferase 2.0
tyrosine hydroxylase 2.0
dopamine beta-hydroxylase 1.9
acyl-CoA dehydrogenase 1.9
pyruvate carboxylase 1.8
lipase 1.7
Alternating 1.7
more...
Compound
Sucrose octaacetate 9.5
Cyproheptadine hydrochloride 9.2
D-Xylose, 8.3
2-Deoxy-D-glucose 8.2
Norfenfluramine 8.2
Norfenfluramine 8.1
Tifluadom 7.9
TDGA 7.8
Naloxonazine 7.6
Opipramol 7.4
Phentermine 7.3
Oleoylethanolamide 7.0
Fenfluramine 6.9
UH-301 6.9
1-(3-chlorophenyl)piperazine 6.8
Ethylketocyclazocine 6.8
DNC 6.7
DNC 6.7
Phenelzine 6.7
Phenelzine 6.6
DIT 6.6
Benzamil 6.5
Bremazocine 6.4
Benztropine 6.4
Olanzapine 6.4
Enterostatin 6.3
Allopregnanolone 6.3
PAPP 6.2
Allopregnanolone 6.2
Acarbose 6.1
PAPP 6.1
Carbimazole 6.1
1,5-AG 5.9
Naltrexone 5.9
SR 141716 5.9
Cyproheptadine 5.9
Parenteral 5.9
STZ 5.8
alpha-MSH 5.8
Umbelliferone 5.8
Morphine sulfate 5.7
Sodium acetate 5.7
Doxepin 5.6
Sibutramine 5.6
ethyl palmitate 5.6
Rilmenidine 5.6
Phenylpropanolamine 5.6
Phenylpropanolamine 5.5
2,4-dichlorophenyl 5.4
2,4-dichlorophenyl 5.4
Topiramate 5.4
Triphosphate 5.4
Cinnamaldehyde 5.4
Idazoxan 5.3
DBI 5.3
DAMGO 5.2
Polydatin 5.2
Sorbinil 5.2
DNC 5.2
2-furoic acid 5.1
MSG 5.1
Lupeol 5.1
Mepyramine 5.0
2-furoic acid 5.0
5-HIAA 5.0
5-FC 4.9
Dynorphin 4.9
Fructosamine 4.9
MeODMT 4.8
N-Acetylglucosamine 4.8
C12H8N2 4.8
Roxithromycin 4.7
NOP 4.7
Methysergide 4.7
DMN 4.7
Zonisamide 4.7
Muscimol 4.7
AEA 4.7
1,3-dioxane 4.6
AEA 4.6
more...