Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0020505 (hyperphagia)
 6,116 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Paradoxically, most if not all previously known appetite-stimulatory hormones are downregulated in human obesity, reflecting failing homeostatic circuitries. Recently, we discovered that acyl-coenzyme-A binding protein/diazepam-binding inhibitor (ACBP/DBI) acts as a lipogenic and appetite stimulator, when systemically injected into mice. ACBP/DBI plasma levels are also elevated in obese subjects, supporting the notion that it may represent the elusive "hunger protein" that explains overeating in human obesity.
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PMID:The elusive "hunger protein": an appetite-stimulatory factor that is overabundant in human obesity. 3169 83