Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0020505 (
hyperphagia
)
6,116
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
AbstractCentral 5-hydroxytryptamine (5-HT), which is primarily synthesized by
tryptophan hydroxylase 2
(
TPH2
) in the dorsal Raphe nuclei (DRN), plays a pivotal role in the regulation of food intake and body weight. However, the physiological functions of
TPH2
on energy balance have not been consistently demonstrated. Here we systematically investigated the effects of
TPH2
on energy homeostasis in adult male and female mice. We found that the DRN harbors a similar amount of TPH2+ cells in control male and female mice. Adult-onset
TPH2
deletion in the DRN promotes
hyperphagia
and body weight gain only in male mice, but not in female mice. Ablation of
TPH2
reduces hypothalamic pro-opiomelanocortin (POMC) neuronal activity robustly in males, but only to a modest degree in females. Deprivation of estrogen by ovariectomy (OVX) causes comparable food intake and weight gain in female control and DRN-specific
TPH2
knockout mice. Nevertheless, disruption of
TPH2
blunts the anorexigenic effects of exogenous estradiol (E2) and abolishes E2-induced activation of POMC neurons in OVX female mice, indicating that
TPH2
is indispensable for E2 to activate POMC neurons and to suppress appetite. Together, our study revealed that
TPH2
in the DRN contributes to energy balance regulation in a sexually dimorphic manner.
...
PMID:TPH2 in the Dorsal Raphe Nuclei Regulates Energy Balance in a Sex-Dependent Manner. 3303 17
