Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020505 (hyperphagia)
 6,116 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Implantation of the Walker 256 carcinoma in lactating rats 2-3 days after parturition had no effect on maternal food intake or pup weight gain over the next 8-9 days. The rate of mammary gland lipogenesis in vivo, which is an index of glucose utilization by the gland, was similar in control and post-partum implanted rats. The accumulation of 14C-lipid in the mammary tissue after an oral load of [1-14C]triolein was also not altered by the presence of the tumor, nor was there evidence for hypertriglyceridaemia. This suggests that the activity of lipoprotein lipase in mammary tissue is not sensitive to the tumor as it appears to be in adipose tissue of non-lactating rats. In contrast, implantation of the tumor 1-2 days before parturition resulted in a faster rate of tumor growth, decreased maternal food intake and decreased pup weight gain compared to either control rats or rats with tumor implanted post-partum. In addition, the rate of mammary gland lipogenesis was decreased by 70% and that of the carcass by 50%. This decrease in lipogenesis is likely to be due to the relative hypophagia in the pre-partum implanted group. The 14C-lipid accumulation in mammary tissue after oral [1-14C]triolein tended to be lower in the pre-partum group but this was not statistically significant. It is concluded that the marked effects on lactation of pre-partum implantation of the tumor are due to effects of the tumor or its presence on the differentiation of the gland around parturition. The alternative explanation that the pre-partum tumor implantation suppresses the stimulus for physiological hyperphagia during lactation is less likely, because this does not occur with the post-partum implantation. The role of putative humoral factors in these effects of the Walker 256 carcinoma in lactation is discussed.
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PMID:Tumor growth and lipid metabolism during lactation in the rat. 325 Feb 34

1. The effect of tumour burden on lipid metabolism was examined in virgin, lactating and litter-removed rats. 2. No differences in food intake or plasma insulin concentrations were observed between control animals and those bearing the Walker-256 carcinoma (3-5% of body wt.) in any group studied. 3. In virgin tumour-bearing animals, there was a significant increase in liver mass, blood glucose and lactate, and plasma triacylglycerol; the rate of oxidation of oral [14C]lipid to 14CO2 was diminished, and parametrial white adipose tissue accumulated less [14C]lipid compared with pair-fed controls. 4. These findings were accompanied by increased accumulation of lipid in plasma and decreased white-adipose-tissue lipoprotein lipase activity. 5. In lactating animals, tumour burden had little effect on the accompanying hyperphagia or on pup weight gain; tissue lipogenesis was unaffected, as was tissue [14C]lipid accumulation, plasma [triacylglycerol] and white-adipose-tissue and mammary-gland lipoprotein lipase activity. 6. On removal (24 h) of the litter, the presence of the tumour resulted in decreased rates of lipogenesis in the carcass, liver and white and brown adipose tissue, decreased [14C]lipid accumulation in white adipose tissue, but increased accumulation in plasma and liver, increased plasma [triacylglycerol] and decreased lipoprotein lipase activity in white adipose tissue. 7. The rate of triacylglycerol/fatty acid substrate cycling was significantly decreased in white adipose tissue of virgin and litter-removed rats bearing the tumour, but not in lactating animals. 8. These results demonstrate no functional impairment of lactation, despite the presence of tumour, and the relative resistance of the lactating mammary gland to the disturbance of lipid metabolism that occurs in white adipose tissue of non-lactating rats with tumour burden.
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PMID:Tissue-specific effects of rapid tumour growth on lipid metabolism in the rat during lactation and on litter removal. 342 10

Combination effects of intravenous hyperalimentation (IVH) and chemotherapy were studied in rats with meningeal carcinomatosis. Sprague-Dawley rats were inoculated intracisternally with 1 X 10(4) Walker 256 carcinosarcoma cells. Animals were divided into five groups of 10 to 12 animals per group: 1) no treatment; 2) cyclophosphamide 30 mg/kg i.v. at 5 days after tumor inoculation (Day 5); 3) IVH (Day 5 to Day 10); 4) cyclophosphamide (Day 5) and IVH (Day 5 to Day 10); and 5) cyclophosphamide (Day 5) and IVH (Day 10 to Day 15). The group of IVH alone reduced survival time significantly (p less than 0.001) compared with no treatment group. Cyclophosphamide alone increased survival time significantly (p less than 0.001) in comparison with no treatment group. Combination of cyclophosphamide (Day 5) and IVH (Day 5 to Day 10) did not prolong survival time compared with cyclophosphamide alone. However, IVH (Day 10 to 15) in combination with cyclophosphamide (Day 5) prolonged survival time significantly (p less than 0.001) in comparison with cyclophosphamide alone. Mean body weight was reduced maximally at 5 to 10 days after cyclophosphamide injection. However, no reduction of body weight was noted while animals were on IVH. The present data appears to indicate that IVH may reduce the side effects of cyclophosphamide and may prolong the survival time.
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PMID:[Combined effect of intravenous hyperalimentation and chemotherapy on experimental meningioma]. 682 Sep 21