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Query: UMLS:C0020505 (hyperphagia)
 6,116 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In Experiment 1, adult female rats were fed, in addition to chow and water, a carbohydrate source that consisted of pure amylopectin corn starch or hydrolyzed corn starch (Polycose) in either a dry powder form or a hydrated gel form. Over the 30-day test periods, carbohydrate intake, total food intake, and body weight gain were greater with the Polycose than with the amylopectin, and greater with the gel form than with the powder form of the carbohydrates. The amylopectin gel produced overeating and overweight relative to a chow-fed control group, although the effects were less than that obtained with the Polycose gel. In a second experiment, test meals of the carbohydrate gels produced larger postmeal increases in plasma glucose than did the carbohydrate powders. There was no effect of carbohydrate type (amylopectin vs. Polycose) on the plasma glucose response. In Experiment 3, the addition of amylopectin to a Polycose gel reduced carbohydrate and total caloric intake. Both orosensory and postingestive factors may contribute to the differential food intake and body weight gains produced by the different types (Polycose vs. amylopectin) and forms (gel vs. powder) of carbohydrates.
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PMID:Starch-induced overeating and overweight in rats: influence of starch type and form. 316 67

Rats fed diets containing 50-71% added water (liquid diets) eat more energy and gain more weight than rats fed the same diets without added water (solid diets). The present experiments examined the effects of making a liquid diet less palatable. The first experiment examined the effects of sucrose octaacetate on diet preference. Rats, given a choice of a liquid diet containing 0.5% sucrose octaacetate and a plain solid diet, preferred the plain solid diet for three weeks. When the concentration of sucrose octaacetate was reduced to 0.05%, the rats did not show a reliable preference for either the sucrose octaacetate liquid or plain dry diet. In subsequent experiments, each rat was given only one diet at a time. In the second experiment, rats were fed 0.5% sucrose octaacetate liquid diet for three weeks followed by 0.05% sucrose octaacetate liquid diet for another four weeks. The rats fed the sucrose octaacetate liquid diet overate and became obese compared to the rats fed plain solid diet throughout. In the third experiment, rats fed 0.5% sucrose octaacetate liquid diet for six weeks became obese compared to rats fed plain solid diet throughout. Thus, the overeating and obesity induced by liquid diets cannot be attributed solely to their high palatability.
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PMID:Overeating, overweight and obesity induced by an unpreferred diet. 319 71

Central and lateral hypothalamic concentrations of 10 regulatory peptides were measured by radioimmunoassay in streptozocin-induced diabetic (STZ-D) and matched control rats between 1 day and 14 wk after diabetes induction. After 2 wk, both central and lateral hypothalamic neuropeptide Y (NPY) concentrations in STZ-D rats were consistently higher than those found in control rats, with significant 30-50% increases at 4 wk in the central hypothalamus, and at 6 and 14 wk in both central and lateral hypothalamus. Immunocytochemical studies in 4- and 6-wk STZ-D animals showed the appearance of intensely NPY-positive swollen cell bodies in the supraoptic nucleus and a subjective increase in NPY staining of medial hypothalamic nerve fibers. Central hypothalamic concentrations of three other peptides were significantly greater in STZ-D animals than those in control animals at single points (neurotensin, 1 day; calcitonin gene-related peptide, 2 wk; neurokinin, 4 wk). Hypothalamic concentrations of the other six peptides examined (bombesin, galanin, neuromedin B, substance P, somatostatin, and vasoactive intestinal peptide) did not differ significantly between STZ-D and control groups at any time. However, galanin immunostaining in the supraoptic and magnocellular paraventricular nuclei was strikingly concentrated in a reduced number of distended cell bodies. Hypothalamic peptide changes in STZ-D could be related to metabolic disturbance, changes in energy and water balance, altered pituitary function, or other factors. Persistently elevated concentrations of NPY, a very potent central stimulant of eating and drinking, may mediate the hyperphagia and polydipsia characteristic of STZ-D.
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PMID:Increased hypothalamic neuropeptide Y concentrations in diabetic rat. 328 97

Adult female rats were fed, in addition to chow and water, a carbohydrate source that differed in type (glucose, sucrose, or polysaccharide), form (32% solution, powder, or gel), or taste (very sweet, minimally sweet, or bitter). A control group was fed only chow and water during the 40-day experiment. The groups fed the glucose solution, sucrose solution, or one of three polysaccharide solutions (Polycose, maltose-dextrin 10, maltose-dextrin 42) all overrate and gained more body weight and fat than did the control group. The carbohydrate solution groups did not differ in their total caloric intake, weight gain, percent body fat, or basal insulin level. The polysaccharide groups, however, consumed more carbohydrate than did the sugar groups. The groups fed glucose, sucrose, or Polycose in powder form consumed less carbohydrate and total calories, gained less weight and fat, and had lower insulin levels than did the groups fed the saccharides in solution form. The powder groups did not reliably differ from the control group on these measures. Rats fed Polycose in solution form or in a solid gel form (32% Polycose + 1% agar) were similar in their carbohydrate intake, total caloric intake, weight gain, and percent body fat. Rats fed Polycose solutions that were minimally sweet (32% Polycose), sweet (0.2% saccharin + 32% Polycose), or bitter [0.05% sucrose octa acetate (SOA) + 32% Polycose] did not differ in their Polycose intake, total caloric intake, weight gain, or percent body fat. The results demonstrate that saccharide form is more important than saccharide type or taste in promoting hyperphagia and obesity in rats. The Polycose gel findings further indicate that it is the water of hydration, not liquidity that is responsible for the hyperphagia-inducing effect of carbohydrate solutions.
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PMID:Carbohydrate-induced hyperphagia and obesity in the rat: effects of saccharide type, form, and taste. 330 91

Xiaoke tea is consumed as a traditional herbal treatment for diabetes mellitus in China. An aqueous extract of Xiaoke (1 g of dried plant preparation in 64 ml of water), supplied ad lib in place of drinking water during the induction and development of streptozotocin diabetes in mice, reduced (about 30%) plasma glucose concentrations by 25 days. The polydipsia and hyperphagia of the streptozotocin diabetic mice were also reduced by Xiaoke, and the effects lapsed after treatment was withdrawn. Xiaoke did not significantly alter plasma insulin concentrations. Consumption of the Xiaoke extract by insulin-treated diabetic BB/E Wistar rats did not affect glycaemic control or body wt. When insulin treatment was reduced and discontinued, Xiaoke failed to prevent the progression of severe hyperglycaemia and weight loss. The results suggest that the slowly generated antihyperglycaemic effect of Xiaoke in streptozotocin diabetic mice may involve an extrapancreatic effect on food intake, glucose production or glucose clearance. However, as evidenced in BB/E rats, Xiaoke does not substitute for insulin in the absence of endogenous insulin secretion.
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PMID:Xiaoke, a traditional Chinese treatment for diabetes. Studies in streptozotocin diabetic mice and spontaneously diabetic BB/E rats. 355 62

The genetically obese (ob/ob) mouse is hyperphagic and hypercorticosteronemic; both hyperphagia and excessive weight gain are ameliorated by adrenalectomy. We report here that corticosterone or dexamethasone stimulate feeding in obese mice at one-fifth the dose needed to increase feeding in lean littermates. Metabolic weight loss, a measure of carbon dioxide and water lost due to respiration, is stimulated by glucocorticoids. Yet we find that obese mice are only one-seventh as sensitive as lean mice to the enhancement of metabolic weight loss following corticosterone. Therefore, hypersensitivity to glucocorticoid-induced feeding and hyposensitivity to glucocorticoid-stimulated weight loss may act in tandem to produce the ob/ob's exaggerated weight gain.
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PMID:Genetically obese (ob/ob) mice are hypersensitive to glucocorticoid stimulation of feeding but dramatically resist glucocorticoid-induced weight loss. 356 Nov 66

Female rats were used to examine the effects of chronic nicotine administration and withdrawal on food and water consumption and body weight. Rats with chronic nicotine pellet implants consumed significantly less food and water than controls for the first five days and then gradually returned to control levels of consumption. The lowest level of body weight was reached on day 9 after which there was a slow return to control weights by day 21. When the nicotine pellets were removed from the short-term exposure group on day 14, they showed significant hyperphagia and hyperdipsia and a very rapid weight gain for the next several days, which clearly outpaced the recovery of weight in the long-term nicotine exposure group. These results show that in female rats changes in weight during chronic nicotine administration and withdrawal are accompanied by changes in rates of consumption. In addition, nicotine withdrawal can cause hyperphagia and hyperdipsia even though levels of consumption had previously returned to control levels and even though the route of nicotine administration was not oral.
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PMID:Chronic nicotine and withdrawal effects on body weight and food and water consumption in female rats. 357 90

Adult male Sprague-Dawley rats were divided into three groups and fed diets containing either 10, 20, or 40% protein for 56 days. Half of the rats in each dietary condition were given a 32% sucrose solution plus the standard diet and water. Sucrose intake varied directly as a function of dietary protein levels. Rats fed either the 10 or 20% protein diet and sucrose had higher caloric intakes, gained more weight, were more efficient at using calories for weight gain, and had more adipose tissue than rats given the same diet without sucrose. Rats fed the 40% protein diet and sucrose did not exhibit overeating, excess weight gain, or increased feed efficiency relative to animals fed the 40% diet alone. Animals given sucrose had more interscapular brown adipose tissue (IBAT) and a greater metabolic potential for thermogenesis in IBAT as determined by GDP binding in mitochondria than rats not fed sucrose. These results demonstrate that dietary protein is important in the development of sucrose-induced obesity and that increases in IBAT mass and activity can occur concomitant with increased feed efficiency.
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PMID:Sucrose-induced obesity: effect of diet on obesity and brown adipose tissue. 360 81

Studies were undertaken to analyze the role of moisture content of foods in producing dietary obesity. Female CD rats consumed more energy when offered a sucrose solution and plain water to drink than when they were only given plain water, regardless of the sugar content of their diet (0-65%). This suggested that the overeating that commonly occurs when sucrose solutions are offered may not be due to sucrose per se. In subsequent experiments, rats were fed modified AIN-76 diets high in sucrose, starch or fat for 28-42 d. For some rats, the diet was liquefied by adding water to make a 32% suspension. Plain drinking water was always available. Rats fed high carbohydrate liquid diets, with or without solid diet, consumed 8-15% more energy than rats fed solid diet only. Rats fed liquid diets also gained 43-206% more weight than did rats fed solid diets. Analysis of carcass composition revealed that the liquid diets increased body fat. For high fat diets, the results were more complicated. Addition of water to a low cellulose, high fat diet did not increase adiposity, whereas addition of water to a high cellulose, high fat diet did increase adiposity. These results suggest that the obesity-inducing effects of feeding sugar solutions or cafeteria diets may be due, in part, to the high water content of these foods.
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PMID:Feeding a liquid diet increases energy intake, weight gain and body fat in rats. 369 90

The reduction of an animal's body weight to 80% of its Free Feeding Weight (FFW) is purported to be an important factor in the generation of schedule-induced behaviour. However, the importance of this factor in schedule-induced hyperphagia is unclear. Experimental studies in schedule-induced hyperphagia reported conflicting results. The aim of the present series of five experiments was to clarify the several conflicting factors in the generation of schedule-induced hyperphagia. Rats reduced to 80% FFW by water restriction and on a Fixed Time (FT) 1-min water delivery schedule showed that body weight reduction, water delivery schedule, size and distance of pellets, and order of schedule presentation were not important factors in the generation of schedule-induced hyperphagia. The failure of the present series of experiments to demonstrate schedule-induced hyperphagia suggests that this behaviour may be a specific class of schedule-induced behaviour that can only be demonstrated under the Bellingham, Wayner and Barone experimental paradigm.
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PMID:Failure to demonstrate schedule-induced hyperphagia with a fixed time 1-minute water delivery schedule. 371 59


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