Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020505 (hyperphagia)
 6,116 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Glutamine has been demonstrated to be an important source of fuel for the gut. The purpose of this study was to evaluate the effect of glutamine-supplemented hyperalimentation on gut immune function. Thirty-six female Fischer rats were randomized into three groups: group 1 (chow) was fed rat chow and water ad libitum, group 2 (total parenteral nutrition) received a standard hyperalimentation formula, and group 3 (total parenteral nutrition-glutamine) received a hyperalimentation solution that contained 2% glutamine. Animals were maintained on their respective diets for 2 weeks and then killed. Mesenteric lymph nodes were harvested for culture, bile was assayed for secretory IgA, and bowel was excised to assay bacterial adherence. Results indicated that glutamine-supplemented total parenteral nutrition protects against bacterial translocation from the gut seen with standard formulas. This effect may be mediated by the secretory IgA immune system.
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PMID:Glutamine-supplemented total parenteral nutrition improves gut immune function. 251 19

Intravenous hyperalimentation and enteral nutrition are the main surgical nutrition methods. IVH play an active role in therapeutic nutrition, although made rapid progress has been made in enteral nutrition, resulting in its wide clinical application. Branched-chain amino acids are useful in improving the nitrogen balance in patients who have undergone major surgical procedures or significant stress. Furthermore, their superiority over a mixed oral protein diet in patients with hepatic encephalopathy has been confirmed clinically. Medium-chain triglycerides (MCT) are an important energy source. Their advantages include easy absorbtion by the intestinal mucosa, lack of stimulation of insulin excretion, and suppression of the reticuloendothelial system. However, the ratio of long-chain triglyceride (LCT) to MCT should be evaluated in many cases. EPA can prevent various adult diseases. Many nutrients contain EPA and it is clinically used both enterally and parenterally. Glutamine is effective in the repair of small intestinal mucosal damage, since it suppresses bacterial translocation, effects of growth hormone, epidermal growth factor (EGF), and nucleic acid on nutritional status are being evaluated clinically. Home enteral nutrition (HEN) has become more common in the past five years although close, cooperation between medical staff and the family is necessary its success.
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PMID:[Progress of enteral nutrition]. 961 94