Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020505 (hyperphagia)
 6,116 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This study considers the effects of glucose, during amino acid infusion, on protein-sparing and amino acid utilization after proctocolectomy or abdominoperineal resection of the rectum. Body composition and plasma amino acids were compared in each of three groups of patients before and 15 days after surgery who were receiving, in addition to restricted oral diets: 1) no hyperalimentation 2) parenteral amino acids or 3) hypertonic glucose plus amino acids. Parenteral solutions were given by central venous catheter. Infusion of amino acids alone spared body protein but branch chain amino acids (i.e. valine, isoleucine and leucine) and also phenylalanine, methionine and proline were increased well above the normal values. There were no increases in liver proteins other than for the "acute phase" type. In contrast, full hyperalimentation spared more body protein and fat, restored plasma amino acids to normal while plasma cortisol and acute pohase proteins were lower. Plasma transferrin, prealbumin and retinol binding protein were increased, as previously shown, while clinical outcome was more favorable. It is concluded that glucose is essential to ensure optimum utilization of amino acids for both muscle and liver protein synthesis and, therefore, intravenous hyperalimentation is preferable to amino acids alone after major colorectal surgery.
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PMID:A controlled study of protein-sparing therapy after excision of the rectum: effects of intravenous amino acids and hyperalimentation on body composition and plasma amino acids. 677 84

Transthyretin (TTR) is a blood and cerebrospinal fluid transporter of thyroxine and retinol. Gene expression profiling revealed an elevation of Ttr expression in the dorsomedial hypothalamus (DMH) of rats with exercise-induced anorexia, implying that central TTR may also play a functional role in modulating food intake and energy balance. To test this hypothesis, we have examined the effects of brain TTR on food intake and body weight and have further determined hypothalamic signaling that may underlie its feeding effect in rats. We found that intracerebroventricular (icv) administration of TTR in normal growing rats decreased food intake and body weight. This effect was not due to sickness as icv TTR did not cause a conditioned taste aversion. ICV TTR decreased neuropeptide Y (NPY) levels in the DMH and the paraventricular nucleus (P < 0.05). Chronic icv infusion of TTR in Otsuka Long-Evans Tokushima Fatty rats reversed hyperphagia and obesity and reduced DMH NPY levels. Overall, these results demonstrate a previously unknown anorectic action of central TTR in the control of energy balance, providing a potential novel target for treating obesity and its comorbidities.
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PMID:Central transthyretin acts to decrease food intake and body weight. 2705